Gauge coupling unification with large extra dimensions

We make a detailed study of the unification of gauge couplings in the MSSM with large extra dimensions. We find some scenarios where unification can be achieved (with the strong coupling constant at the Z mass within one standard deviation of the experimental value) with both the compactification scale and the SUSY breaking scale in the few TeV range. No enlargement of the gauge group or particle content is needed. One particularly interesting scenario is when the SUSY breaking scale is larger than the compactification scale, but both are small enough to be probed at the CERN LHC. Unification in two scales scenarios is also investigated and found to give results within the LHC.Comment: 17 pages, 3 figures, some discussions added, few additional references included. Version to appear in Phys. Rev.

Discrimination of low missing energy look-alikes at the LHC

The problem of discriminating possible scenarios of TeV scale new physics with large missing energy signature at the Large Hadron Collider (LHC) has received some attention in the recent past. We consider the complementary, and yet unexplored, case of theories predicting much softer missing energy spectra. As there is enough scope for such models to fake each other by having similar final states at the LHC, we have outlined a systematic method based on a combination of different kinematic features which can be used to distinguish among different possibilities. These features often trace back to the underlying mass spectrum and the spins of the new particles present in these models. As examples of "low missing energy look-alikes", we consider Supersymmetry with R-parity violation, Universal Extra Dimensions with both KK-parity conserved and KK-parity violated and the Littlest Higgs model with T-parity violated by the Wess-Zumino-Witten anomaly term. Through detailed Monte Carlo analysis of the four and higher lepton final states predicted by these models, we show that the models in their minimal forms may be distinguished at the LHC, while non-minimal variations can always leave scope for further confusion. We find that, for strongly interacting new particle mass-scale ~600 GeV (1 TeV), the simplest versions of the different theories can be discriminated at the LHC running at sqrt{s}=14 TeV within an integrated luminosity of 5 (30) fb^{-1}.Comment: 40 pages, 10 figures; v2: Further discussions, analysis and one figure added, ordering of certain sections changed, minor modifications in the abstract, version as published in JHE

ANTIMICROBIAL AND IN SILICO ADMET SCREENING OF NOVEL (E)-N-(2-(1H-INDOL-3-YL-AMINO) VINYL)-3-(1-METHYL-1H-INDOL-3-YL)-3-PHENYLPROPANAMIDE DERIVATIVES

Objective: Synthesis, in silico absorption, distribution, metabolism, excretion, toxicity (ADMET) and in vitro antimicrobial screening of (E)-N-(2-(1H-indol-3-ylamino) vinyl)-3-(1-methyl-1H-indol-3-yl)-3-phenylpropanamide derivatives.Methods: (E)-N-(2-(1H-indol-3-ylamino) vinyl)-3-(1-methyl-1H-indol-3-yl)-3 phenylpropane-amide derivatives were synthesized by combining indole ethanolamine and substituted Meldrum's adduct. The synthesized compounds were subjected to in vitro antimicrobial study by cup plate method and in silico ADMET properties using ACD/I-Lab 2.0.Results: The in vitro antimicrobial screening against precarious pathogenic microorganisms viz, Pseudomonas aureginosa, Staphylococcus aureus, Escherichia coli, Vibrio cholerae, and the antifungal activity against Candida albicans, Aspergillus niger, Penicillin chrysogenum and Cladosporium oxysporum strains. The results revealed that compounds 5b, 5c, 5d and 5e showed good antimicrobial property and obeyed the in silico pharmacokinetic parameters.Conclusion: The encouraging results exhibited by the compounds (E)-N-(2-(1H-indol-3-ylamino) vinyl)-3-(1-methyl-1H-indol-3-yl)-3-phenyl propanamide derivatives, 5(a-e) can be explored as possible hits in antimicrobial therapy. The molecules obey the Lipinski rule of five when tested in silico and can be used in understanding the quantitative structure-activity relationship (QSAR) parameters

Stranding of spinner dolphin, Stenella longirostris (Gray, 1828) at Karwar, Karnataka

A spinner dolphin, Stenella longirostris , locally called ‘handi meenu’ was noticed in dead condition floating near the marine cage farm of CMFRI, Karwar, approximately 600 m away, from sea shore of Aligadda village in the evening hours on 31st August 2012. The specimen was an adult female of 175 cm total length and 55 kg weight. The animal had a small injury near its left eye probably as a result of getting entangled in fishing nets or got injured in purse-seine operation which resulted in its death

2-(4-Bromo­phen­yl)-2-oxoethyl anthracene-9-carboxyl­ate

In the title compound, C23H15BrO3, the anthracene ring system is essentially planar [maximum deviation = 0.29 (2) Å] and makes a dihedral angle of 5.74 (8)° with the mean plane of the bromo-substituted benzene ring. An intra­molecular C—H⋯O hydrogen bond generates an S(9) ring motif. In the crystal, mol­ecules are linked by C—H⋯O inter­actions, forming a two-dimensional network parallel to the ac plane. π–π stacking inter­actions are observed between benzene rings [centroid–centroid distances = 3.5949 (14) and 3.5960 (13) Å]

ANTIPROLIFERATIVE, ADME AND POTENTIAL IN SILICO G6PDH INHIBITORY ACTIVITY OF NOVEL 2-(1-BENZOFURAN-2-YL)-4-(5-PHENYL-4H-1, 2, 4-TRIAZOL-3-YL) QUINOLINE DERIVATIVES

Objectives: Synthesis of new 2-(1-benzofuran-2-yl)-4-(5-phenyl-4H-1, 2, 4-triazol-3-yl) quinoline and its derivatives for antiproliferative potential against cancer cells.Methods: The general methods were employed for the synthesis and the structures were confirmed by IR, 1H-NMR, 13C-NMR and mass spectral analysis. The antiproliferative activity was performed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and molecular docking study were performed by Auto Dock Tools. In silico Absorption-Distribution-Metabolism-Excretion-Toxicity (ADMET) study for the drug, likeliness was carried out on ACD/lab-2.Results: The compound 3l showed 44, 44, 38 and 37 % inhibition against MCF-7, HepG2, Colo205 and HeLa cell lines, respectively; whereas, the compounds 3i and 3j exhibited 49 and 42 % inhibition against MCF-7 cell line. The molecular docking study revealed that the compound 3i has the lowest binding energy (-8.60 Kcal mol-1), suggesting to be potentially best inhibitor of Glucose-6-phosphate dehydrogenase (G6PDH). The in silico ADME analysis also revealed that compound 3i does not violate any of the Lipinski rules of five and has the best stimulative human colonic absorption up to 95 %.Conclusion: The study reveals that the compounds containing benzofuran coupled nitrogen heterocycles are essential for activity as they possess excellent drug-like characteristics.Â

Testing gravitational-wave searches with numerical relativity waveforms: Results from the first Numerical INJection Analysis (NINJA) project

The Numerical INJection Analysis (NINJA) project is a collaborative effort between members of the numerical relativity and gravitational-wave data analysis communities. The purpose of NINJA is to study the sensitivity of existing gravitational-wave search algorithms using numerically generated waveforms and to foster closer collaboration between the numerical relativity and data analysis communities. We describe the results of the first NINJA analysis which focused on gravitational waveforms from binary black hole coalescence. Ten numerical relativity groups contributed numerical data which were used to generate a set of gravitational-wave signals. These signals were injected into a simulated data set, designed to mimic the response of the Initial LIGO and Virgo gravitational-wave detectors. Nine groups analysed this data using search and parameter-estimation pipelines. Matched filter algorithms, un-modelled-burst searches and Bayesian parameter-estimation and model-selection algorithms were applied to the data. We report the efficiency of these search methods in detecting the numerical waveforms and measuring their parameters. We describe preliminary comparisons between the different search methods and suggest improvements for future NINJA analyses.Comment: 56 pages, 25 figures; various clarifications; accepted to CQ

Synthesis And Characterization Of Graphene Oxide –Polyoxometalate Composite Material For Device Applications

Polyoxometalates (POMs) consisting of clusters of d-block transition metals and oxygen atoms represent an important class of water soluble polynuclear nanomaterial. The tuneable size, structure and elemental composition of POM draws considerable attention for the development of functional composite materials of desired chemical and electronic properties.[1] Graphene can be the promising support for POMs due to its low band gap energy and fast electron transport properties. These properties of grapheme facilitates transport of electrons of POMs rapidly and effectively.[2] In the present investigation, graphene oxide (GO) and reduced graphene oxide (rGO) have been used as a support for POM-graphene composites for semiconductor, hydrogen production applications.[2] The deposition of POM on graphene oxide sheets were carried out through electron transfer interaction and electrostatic interaction between POM and GO sheets. ...

Cytotoxicity effect and antioxidant potential of 5-Hydroxymethyl Furfural (5-HMF) analogues-An advance approach

Rivea hypocrateriformis (Desr.) Choisy is a profound medicinal belongs to the family Convolvulaceae. Natural products are considered as an alternative source for a positive approach to the drug design and drug discovery. R. hypocrateriformis is becoming the most important natural source to produce diverse phytometabolites with varying biochemical activities. Therefore, in the proposed study, we utilizing R. hypocrateriformis for isolating the 5-hydroxymethyl-2-furfural (5-HMF) and characterized it by different scientifically approved spectroscopic techniques namely 1HNMR, 13C NMR, FTIR and mass spectroscopy respectively. As a part of this study, the synthesis of chemical analogues has been achieved by coupling 5-HMF with quinoline derivatives and it was also studied for their antioxidant and anticancer potentials. The results demonstrated that amongst the test compounds, 3d and 3b have shown significant free radical scavenging assay followed by 3e and 3a with a maximum inhibitory effect, 76.69 %, 75.90 %, 67.60 % and 56.07 % respectively at 50 μg/mL. The anticancer activity studied through SRB assay showed that, compound 3a was effective at low concentration (10 μg/mL) against the Colo-205 cell line. This study demonstrated the applicability of R. hypocrateriformis against the cytotoxicity and antioxidant potential of 5-HMF. It can further be utilized by the researcher and pharmaceutical industry to design a potential drug candidate to treat cellular toxicity