Fragmentation and the digital city: An analysis of Vicente Luis Mora's circular 07. Las afueras

This essay juxtaposes three recent publications, Vicente Luis Mora's Circular 07. Las afueras (2007-), Kenneth Goldsmith's Capital: New York, Capital of the 20th Century (2015), and Jorge Carrión's Barcelona. Libro de los pasajes (2016), in order to explore how contemporary digital technologies construct and fragment urban experience on a global scale. Despite their different political intentions, these three works share a common aesthetic of appropriation, unoriginal quotation, and fragmentation, as they are also all modelled after Walter Benjamin's Arcades Project. Just like Benjamin did with Paris, each of these works focuses on a particular Western city-Madrid, New York, and Barcelona-now being proposed as paradigmatic representations of urban experience, which is meant to mimic digital media's modularity and disintegration. Goldsmith's use of appropriation is read as a blank endorsement of digital mediation of everyday life, which sits in opposition to Carrión's and Mora's political projects. Circular 07 and Barcelona mix unoriginal writing techniques, like Goldsmith's conceptual writing, with other experimental methods to warn readers against apolitical adoption of digital technologies. Fragmentation is still proposed as the most important aesthetic form of twenty-first century writing, but these two Spanish works strive for its contextualization as a complex mechanism structured around reader/writer subjectivity. Finally, this essay ponders how to consider new reader/ writer subjectivities within the larger context of global cities in late capitalism

Federal Grants and the Problem of Financing Public Assistance

Livestock and poultry are two growing subsectors of global farming economy with an impact on the environment and thus deserving closer attention. While the farms play a major role in providing protein essential for human diets, they are also sources of significant amounts of greenhouse gas (GHG) emissions. Hence, the sectors need to improve their environmental performance and mitigate their negative impacts on climate. To estimate the annual GHG emissions from a dairy and poultry farm, a case study was conducted in the rural area of Bangladesh. The study has considered the supply chains of both farms while estimating the emissions.  The study also estimated the GHG emission reduction potential of a small biogas based polygeneration system aimed at providing energy services in the rural area. LCA (lifecycle assessment) has been used as the main tool while estimating the emissions

The Karamojong women and extreme insecurity

Research assistant Saum Nangiro discusses how she, Julian Hopwood and Holly Porter explored the way justice and security systems work in relation to women and children in the Karamoja region in Northeast Uganda

Ceftriaxone Potentiates Warfarin Activity Greater Than Other Antibiotics in the Treatment of Urinary Tract Infections

Background: The cephalosporin class has been associated with an increased risk of bleeding among elderly patients receiving warfarin. Urinary tract infections (UTI) are the most prevalent infection in elderly patients. Objective: To determine the extent of interaction between antibiotics used in the treatment of UTI, particularly specific cephalosporins and warfarin. Methods: A retrospective chart review was conducted on chronic warfarin patients with a diagnosis of UTI treated with ceftriaxone, a first-generation cephalosporin, penicillin, or ciprofloxacin. The primary outcome was the comparison of the extent of international normalized ratio (INR) change from baseline between each antibiotic group. Results: The ceftriaxone group was found to have a statistically significant higher peak INR value compared to all other studied antibiotics (ceftriaxone: 3.56, first-generation cephalosporins: 2.66, penicillins: 2.98, ciprofloxacin: 2.3; P = .004), a statistically significant greater extent of change in INR value (+1.19, +0.66, +0.8, +0.275; P = .006), and a statistically significant greater percentage change in INR value when compared to ciprofloxacin (54.4% vs 12.7%; P = .037). Conclusion: Ceftriaxone interacts with warfarin to increase a patient’s INR value more than other commonly administered antibiotics for UTI treatment. Other antibiotics should be preferred for UTI treatment in patients on warfarin

Host and symbiont genetic contributions to fitness in a Trichogramma-Wolbachia symbiosis.

The fitness effects associated with Wolbachia infection have wide-ranging ecological and evolutionary consequences for host species. How these effects are modulated by the relative influence of host and Wolbachia genomes has been described as a balancing act of genomic cooperation and conflict. For vertically transmitted symbionts, like cytoplasmic Wolbachia, concordant host-symbiont fitness interests would seem to select for genomic cooperation. However, Wolbachia's ability to manipulate host reproductive systems and distort offspring sex ratios presents an evolutionary conflict of interest with infected hosts. In the parthenogenesis-inducing (PI) form of Wolbachia found in many haplodiploid insects, Wolbachia fitness is realized through females and is enhanced by their feminization of male embryos and subsequent parthenogenetic reproduction. In contrast, as long as Wolbachia is not fixed in a population and sexual reproduction persists, fitness for the host species is realized through both male and female offspring production. How these cooperating and competing interests interact and the relative influence of host and Wolbachia genomes were investigated in the egg parasitoid Trichogramma kaykai, where Wolbachia infection has remained at a low frequency in the field. A factorial design in which laboratory cultures of Wolbachia-infected T. kaykai were cured and re-infected with alternative Wolbachia strains was used to determine the relative influence of host and Wolbachia genomes on host fitness values. Our results suggest fitness variation is largely a function of host genetic background, except in the case of offspring sex ratio where a significant interaction between host and Wolbachia genomes was found. We also find a significant effect associated with the horizontal transfer of Wolbachia strains, which we discuss in terms of the potential for coadaptation in PI-Wolbachia symbioses

Ascorbic Acid for the Treatment of Rasburicase induced Methemoglobinemia in the Setting of Acute Renal Failure

Purpose A case of apparent rasburicase-induced methemoglobinemia and acute kidney injury treated with i.v. ascorbic acid because of suspected glucose-6-phosphate dehydrogenase (G6PD) deficiency is reported. Summary A 46-year-old African-American man with a recent diagnosis of multiple myeloma and renal insufficiency was admitted to the hospital with a cough, hemoptysis, and fatigue. His medical history included hypertrophic cardiomyopathy, ventricular tachycardia, attention deficit/hyperactivity disorder, and pleural effusion. No treatments for multiple myeloma were started before hospital admission. Levofloxacin 750 mg orally daily for possible pneumonia, lenalidomide 10 mg orally daily, and dexamethasone 20 mg orally weekly were administered. Plasmapheresis was also initiated. Laboratory test results revealed sustained hyperuricemia, which was believed to be due in part to tumor lysis, and a single dose of rasburicase 6 mg i.v. was administered. Subsequently, the patient experienced a decrease in oxygen saturation. Methemoglobinemia was suspected, and the patient’s methemoglobin fraction was found to be 14.5%. The patient developed worsening shortness of breath and a drop in hemoglobin concentration, consistent with methemoglobinemia and hemolysis. Ascorbic acid 5 g i.v. every 6 hours was initiated for a total of six doses. Because the patient was assumed to have G6PD deficiency, which was later confirmed, methylene blue was avoided. Within 24 hours, the patient’s oxygen saturation values and symptoms improved. Conclusion A patient with apparent rasburicase-induced methemoglobinemia and acute kidney injury was treated with i.v. ascorbic acid (5 g every six hours for six doses) because of the possibility, later proved, that he had G6PD deficiency. The methemoglobinemia resolved without worsening of renal function

Geriatric Medication Therapy: Weighing the Evidence versus Best Practice

Goals: The goal of this article is to provide a review of available evidence for safe prescribing in older adults and recommend medication therapies based on anticipated pharmacokinetic/physiologic changes in this population