Defining Normative OCTA Vascular Density Values and AI-Based Vascular Ageing Models for Glaucoma Risk Assessment

This thesis focuses on establishing normative vascular density values using optical coherence tomography angiography (OCTA) in healthy subjects, evaluating their clinical relevance in the early detection and monitoring of glaucoma progression. Through a systematic assessment of peripapillary and macular vascular parameters, the study provides robust reference values essential for interpreting physiological variations associated with age, sex, and other risk factors. The work highlights the critical role of retinal vascularisation in the development and progression of glaucoma, a major neurodegenerative disease that remains challenging to diagnose at its earliest stages. By offering a detailed analysis of structural and vascular biomarkers, this thesis lays the foundation for a more personalized approach to risk stratification and patient care in glaucoma. Building upon these scientific foundations, the thesis proposes a conceptual framework for the future development of artificial intelligence (AI) models, such as GlauOCTA and GlauOCTA-AI, which are currently in the design phase. These models aim to predict glaucoma progression by detecting subtle vascular patterns that remain clinically invisible during the early stages of the disease, potentially allowing for earlier intervention. The study further addresses the ethical challenges associated with integrating AI in ophthalmology, including concerns about algorithmic bias, transparency, medical accountability, and the preservation of human clinical judgment. AI is positioned as a complementary tool intended to enhance, not replace, the expertise of clinicians. In conclusion, this research establishes the groundwork for the future development of AI-assisted glaucoma diagnostic tools based on vascular biomarkers, while advocating for a more ethical, proactive, and patient-centred approach to precision medicine in ophthalmology.(MED - Sciences médicales) -- UCL, 202

Intermediary inflammatory reaction after micropulse cyclophotocoagulation diode therapy: a case report

Abstract Introduction Of the many types of laser cyclophotocoagulation procedures, micropulse cyclophotocoagulation diode is praised as a noninvasive, safe, and effective procedure with few complications. In this case report, we describe a rare complication that, to the best of our knowledge, has not been previously reported. Case report We report on the case of a 66-year-old African man with a history of end-stage primary open-angle glaucoma. One week after undergoing micropulse cyclophotocoagulation diode therapy in both eyes, he developed severe intermediary inflammation in one eye, associated with decreased visual acuity. The intraocular pressure had significantly decreased after the procedure and was well controlled with intraocular-pressure-lowering medications. Slit lamp examination revealed a moderate anterior chamber inflammation, anterior vitritis, and a large inflammatory membrane attached to the posterior surface of the intraocular implant. A vitrectomy was finally performed in the left eye because of the persistent intermediary inflammation despite the use of high doses of topical and subconjunctival corticosteroids. Conclusion Intermediary uveitis is a rare complication after micropulse cyclophotocoagulation diode therapy. To the best of our knowledge, there have been no reports of vitritis after a noncomplicated micropulse cyclophotocoagulation diode in primary open-angle glaucoma. </jats:sec

Lasers et glaucomes en 2014

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Intermediary inflammatory reaction after micropulse cyclophotocoagulation diode therapy: a case report.

Of the many types of laser cyclophotocoagulation procedures, micropulse cyclophotocoagulation diode is praised as a noninvasive, safe, and effective procedure with few complications. In this case report, we describe a rare complication that, to the best of our knowledge, has not been previously reported. We report on the case of a 66-year-old African man with a history of end-stage primary open-angle glaucoma. One week after undergoing micropulse cyclophotocoagulation diode therapy in both eyes, he developed severe intermediary inflammation in one eye, associated with decreased visual acuity. The intraocular pressure had significantly decreased after the procedure and was well controlled with intraocular-pressure-lowering medications. Slit lamp examination revealed a moderate anterior chamber inflammation, anterior vitritis, and a large inflammatory membrane attached to the posterior surface of the intraocular implant. A vitrectomy was finally performed in the left eye because of the persistent intermediary inflammation despite the use of high doses of topical and subconjunctival corticosteroids. Intermediary uveitis is a rare complication after micropulse cyclophotocoagulation diode therapy. To the best of our knowledge, there have been no reports of vitritis after a noncomplicated micropulse cyclophotocoagulation diode in primary open-angle glaucoma

Effect of topical corneal anaesthesia on ocular response analyzer parameters: pilot study.

The effect of topical corneal anaesthesia on corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal compensated IOP (IOPcc) was measured by ocular response analyzer (ORA).Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Evaluation of corneal biomechanical properties with the Reichert Ocular Response Analyzer.

Purpose. To compare corneal hysteresis (CH) and corneal resistance factor (CRF) measured with the Ocular Response Analyzer (ORA) in patients with primary open-angle glaucoma (POAG), patients with ocular hypertension (OHT), and normal subjects (NL); and to assess correlations of CH and CRF with corneal-compensated intraocular pressure (IOPcc), Goldmann applanation tonometry (GAT), glaucoma type, central corneal thickness (CCT), previous filtering procedure, and antiglaucoma medications. Methods. A total of 108 POAG, 22 OHT, and 24 NL were enrolled in this observational study. Goldmann applanation tonometry and ORA were performed in a randomized sequence followed by pachymetry. One eye per subject was selected at random for analysis. Chi-square, Wilcoxon, and Kruskal-Wallis tests were used for comparison and Spearman coefficient for assessing correlations. Results. Mean CH and CRF were significantly lower in POAG than in OHT and NL. Ocular Response Analyzer IOPcc overestimated IOP compared to GAT only in POAG. This difference increased with higher GAT. Goldmann applanation tonometry and IOPcc were correlated. Corneal hysteresis was negatively correlated with age in POAG. Corneal resistance factor and CH were positively correlated with CCT in POAG and OHT. Unlike CRF, CH was not correlated with GAT in POAG and OHT. Corneal-compensated intraocular pressure was not correlated with CCT. Difference between GAT and IOPcc was not CCT dependent. Corneal hysteresis and CRF were comparable in POAG and NTG, unchanged after filtering procedure. Corneal hysteresis was not altered by topical medications. Corneal resistance factor was significantly lower in treated eyes and those receiving prostaglandin analogues with no correlation with the treatment duration. Conclusions. Patients with glaucoma seem to have distinctive corneal biomechanical properties compared to OHT and NL. They may be influenced by many other unknown subparameters

Neuroprotection in glaucoma: Nutrition and medication

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Influence of corneal hysteresis on glaucomatous visual field damage.

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Updates to surgical options in glaucoma

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Analyse de la papille glaucomateuse :avec ou sans champ visuel

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