815 research outputs found

    Granular superconductivity at room temperature in bulk highly oriented pyrolytic graphite samples

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    We have studied the magnetic response of two bulk highly oriented pyrolytic graphite (HOPG) samples with different internal microstructure. For the sample with well defined interfaces, parallel to the graphene layers, the temperature and magnetic field hysteresis are similar to those found recently in water-treated graphite powders. The observed behavior indicates the existence of granular superconductivity above room temperature in agreement with previous reports in other graphite samples. The granular superconductivity behavior is observed only for fields normal to the embedded interfaces, whereas no relevant hysteresis in temperature or field is observed for fields applied parallel to them. Increasing the temperature above 400\sim 400 K changes irreversibly the hysteretic response of the sample.Comment: 36 pages with 13 figure

    Analyzing Competing Risk Data Using the R timereg Package

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    In this paper we describe flexible competing risks regression models using the comp.risk() function available in the timereg package for R based on Scheike et al. (2008). Regression models are specified for the transition probabilities, that is the cumulative incidence in the competing risks setting. The model contains the Fine and Gray (1999) model as a special case. This can be used to do goodness-of-fit test for the subdistribution hazardsâ proportionality assumption (Scheike and Zhang 2008). The program can also construct confidence bands for predicted cumulative incidence curves. We apply the methods to data on follicular cell lymphoma from Pintilie (2007), where the competing risks are disease relapse and death without relapse. There is important non-proportionality present in the data, and it is demonstrated how one can analyze these data using the flexible regression models.

    Time-varying effects when analysing customer lifetime duration, application to the insurance market

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    The Cox model (Cox, 1972) is widely used in customer lifetime duration research, but it assumes that the regression coefficients are time invariant. In order to analyse the temporal covariate effects on the duration times, we propose to use an extended version of the Cox model where the parameters are allowed to vary over time. We apply this methodology to real insurance policy cancellation data and we conclude that the kind of contracts held by the customer and the concurrence of an external insurer in the cancellation influence the risk of the customer leaving the company, but the effect differs as time goes by.Cox model, customer lifetime.

    The Liability Threshold Model for Censored Twin Data

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    Family studies provide an important tool for understanding etiology of diseases, with the key aim of discovering evidence of family aggregation and to determine if such aggregation can be attributed to genetic components. Heritability and concordance estimates are routinely calculated in twin studies of diseases, as a way of quantifying such genetic contribution. The endpoint in these studies are typically defined as occurrence of a disease versus death without the disease. However, a large fraction of the subjects may still be alive at the time of follow-up without having experienced the disease thus still being at risk. Ignoring this right-censoring can lead to severely biased estimates. We propose to extend the classical liability threshold model with inverse probability of censoring weighting of complete observations. This leads to a flexible way of modeling twin concordance and obtaining consistent estimates of heritability. We apply the method in simulations and to data from the population based Danish twin cohort where we describe the dependence in prostate cancer occurrence in twins

    Time-varying effects when analysing customer lifetime duration: application to the insurance market

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    The Cox model (Cox, 1972) is widely used in customer lifetime duration research, but it assumes that the regression coefficients are time invariant. In order to analyse the temporal covariate effects on the duration times, we propose to use an extended version of the Cox model where the parameters are allowed to vary over time. We apply this methodology to real insurance policy cancellation data and we conclude that the kind of contracts held by the customer and the concurrence of an external insurer in the cancellation influence the risk of the customer leaving the company, but the effect differs as time goes by

    A Cox-Aalen model for interval-censored data

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    This is the peer reviewed version of the following article: Boruvka, A., and Cook, R. J. (2015), A Cox-Aalen Model for Interval-censored Data. Scand J Statist, 42, 414–426. doi: 10.1111/sjos.12113., which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/sjos.12113/full. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.The Cox-Aalen model, obtained by replacing the baseline hazard function in the well-known Cox model with a covariate-dependent Aalen model, allows for both fixed and dynamic covariate effects. In this paper, we examine maximum likelihood estimation for a Cox-Aalen model based on interval-censored failure times with fixed covariates. The resulting estimator globally converges to the truth slower than the parametric rate, but its finite-dimensional component is asymptotically efficient. Numerical studies show that estimation via a constrained Newton method performs well in terms of both finite sample properties and processing time for moderate-to-large samples with few covariates. We conclude with an application of the proposed methods to assess risk factors for disease progression in psoriatic arthritis.Natural Sciences and Engineering Research Council of Canada (RGPIN 155849); Canadian Institutes for Health Research (FRN 13887); Canada Research Chair (Tier 1) – CIHR funded (950-226626

    Development of a Fetal Weight Chart using Serial Trans-Abdominal Ultrasound in an East African Population: A Longitudinal Observational Study.

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    To produce a fetal weight chart representative of a Tanzanian population, and compare it to weight charts from Sub-Saharan Africa and the developed world. A longitudinal observational study in Northeastern Tanzania. Pregnant women were followed throughout pregnancy with serial trans-abdominal ultrasound. All pregnancies with pathology were excluded and a chart representing the optimal growth potential was developed using fetal weights and birth weights. The weight chart was compared to a chart from Congo, a chart representing a white population, and a chart representing a white population but adapted to the study population. The prevalence of SGA was assessed using all four charts. A total of 2193 weight measurements from 583 fetuses/newborns were included in the fetal weight chart. Our chart had lower percentiles than all the other charts. Most importantly, in the end of pregnancy, the 10(th) percentiles deviated substantially causing an overestimation of the true prevalence of SGA newborns if our chart had not been used. We developed a weight chart representative for a Tanzanian population and provide evidence for the necessity of developing regional specific weight charts for correct identification of SGA. Our weight chart is an important tool that can be used for clinical risk assessments of newborns and for evaluating the effect of intrauterine exposures on fetal and newborn weight
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