A Technique for generating Feynman Diagrams

We present a simple technique that allows to generate Feynman diagrams for vector models with interactions of order $2n$ and similar models (Gross-Neveu, Thirring model), using a bootstrap equation that uses only the free field value of the energy as an input. The method allows to find the diagrams to, in principle, arbitrarily high order and applies to both energy and correlation functions. It automatically generates the correct symmetry factor (as a function of the number of components of the field) and the correct sign for any diagram in the case of fermion loops. We briefly discuss the possibility of treating QED as a Thirring model with non-local interaction.Comment: 19 pages, LateX, To be published in Z. f. Phys.

Varicella paediatric hospitalisations in Belgium : a 1-year national survey

Background: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year period. Methods: Data on children admitted to hospital with varicella were collected through a national network from November 2011 to October 2012. Inclusion criteria were either acute varicella or related complications up to 3 weeks after the rash. Results: Participation of 101 hospitals was obtained, covering 97.7% of the total paediatric beds in Belgium. 552 children were included with a median age of 2.1 years. Incidence of paediatric varicella hospitalisations reached 29.5/105 person-years, with the highest impact among those 0-4 years old (global incidence and odds of hospitalisation: 79/105 person-years and 1.6/100 varicella cases, respectively). Only 14% (79/552) of the cohort had an underlying chronic condition. 65% (357/552) of children had >= 1 complication justifying their admission, 49% were bacterial superinfections and 10% neurological disorders. Only a quarter of children (141/ 552) received acyclovir. Incidence of complicated hospitalised cases was 19/10(5) person-years. Paediatric intensive care unit admission and surgery were required in 4% and 3% of hospitalised cases, respectively. Mortality among Belgian paediatric population was 0.5/106 and fatality ratio 0.2% among our cohort. Conclusions: Varicella demonstrated a substantial burden of disease in Belgian children, especially among the youngest. Our thorough nationwide study, run in a country without varicella UV, offers data to support varicella UV in Belgium

Impact of Fusarium mycotoxins on in vitro activity of major hepatic cytochrome P450 biotransformation enzymes in pigs

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Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective

Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism. Porcine CYP450 has been demonstrated to convert typical substrates of human CYP450. Nevertheless, knowledge and insight into porcine CYP450 quantity and substrate selectivity is scant, especially regarding intestinal CYP450. The current study aimed to map the quantities of hepatic and intestinal CYP450 in the conventional pig by using a proteomic approach. Moreover, the selectivity of the six most common used probe substrates (phenacetin, coumarin, midazolam, tolbutamide, dextromethorphan, and chlorzoxazone) for drug metabolizing enzyme subfamilies (CYP1A, CYP2A, CYP3A, CYP2C, CYP2D and CYP2E respectively), was investigated. Hepatic relative quantities were 4% (CYP1A), 31% (CYP2A), 14% (CYP3A), 10% (CYP2C), 28% (CYP2D) and 13% (CYP2E), whereas for the intestine only duodenal CYP450 could be determined with 88% for CYP3A and 12% for CYP2C. Furthermore, the results indicate that coumarin (CYP2A), midazolam (CYP3A), tolbutamide (CYP2C), and dextromethorphan (CYP2D) are as selective for porcine as for human CYP450. However, phenacetin (CYP1A2) and chlorzoxazone (CYP2E1) are less selective for the specific enzyme, despite similarities in selectivity towards the different enzymes involved compared to humans

A simple algorithm for automatic Feynman diagram generation

An algorithm for the automatic Feynman diagram (FD) generation is presented in this paper. The algorithm starts directly from the definition formula of FD, and is simple in concept and easy for coding. The symmetry factor for each FD is naturally generated. It is expected to bring convenience for the researchers who are studying new calculation techniques or making new calculation tools and for the researchers who are studying effective field theory. A C-program made from the algorithm is also presented, which is short, fast, yet very general purpose: it receives arbitrary user defined model and arbitrary process as input and generates FD's at any order.Comment: 11 pages, 2 figure

Construction, start-up and operation of a continuously aerated laboratory-scale SHARON reactor in view of coupling with an Anammox reactor

In this study practical experiences during start-up and operation of a laboratory-scale SHARON reactor are discussed, along with the construction of the reactor. Special attention is given to the start-up in view of possible toxic effects of high nitrogen concentrations (up to 4 000 mgN(.)l(-1)) on the nitrifier population and because the reactor was inoculated with sludge from an SBR reactor operated under completely different conditions. Because of these considerations, the reactor was first operated as an SBR to prevent biomass washout and to allow the selection of a strong nitrifying population. A month after the inoculation the reactor was switched to normal chemostat operation. As a result the nitrite oxidisers were washed out and only the ammonium oxidisers persisted in the reactor. In this contribution also some practical considerations concerning the operation of a continuously aerated SHARON reactor, such as mixing, evaporation and wall growth are discussed. These considerations are not trivial, since the reactor will be used for kinetic characterisation and modelling studies. Finally the performance of the SHARON reactor under different conditions is discussed in view of its coupling with an Anammox unit. Full nitrification was proven to be feasible for nitrogen loads up to 1.5 gTAN-N(.)l(-1.)d(-1), indicating the possibility of the SHARON process to treat highly loaded nitrogen streams. Applying different influent concentrations led to different effluent characteristics indicating the need for proper control of the SHARON reactor

Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes/ABC drug transporters in a porcine animal model

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Large N limit of O(N) vector models

Using a simple identity between various partial derivatives of the energy of the vector model in 0+0 dimensions, we derive explicit results for the coefficients of the large N expansion of the model. These coefficients are functions in a variable $\rho^2$, which is the expectation value of the two point function in the limit $N=\infty$. These functions are analytic and have only one (multiple) pole in $\rho^2$. We show to all orders that these expressions obey a given general formula. Using this formula it is possible to derive the double scaling limit in an alternative way. All the results obtained for the double scaling limit agree with earlier calculations. (to be published in Physics Letters B)Comment: 12 page