A double network approach to international production.

This paper discusses some key implications of the view, emerged in the literature, that multinational firms organise their activities by connecting internal networks of subsidiaries with external networks of contractual relationships. It is argued that this view provides some useful elements for a more comprehensive theory of multinational change and for the analysis of the impact of internationalisation on economic systems of origin and destination. A “double network approach” to international production implies a fundamental change of focus from the “center” of multinationals – the headquarters – to the “periphery” of transnational organisations, and from individual decision making units to collective choices involving a variety of inter-linked actors. Moreover, it highlights the complexities of decision making processes associated to the increasing number and interdependencies of internal and external actors involved in international production.Foreign Investment, Multinational Firm.

The effects of local systems on the international de-localisation of production.The case of made in Italy

The paper examines the fragmentation of production from the view-point of industrialised countries. From this perspective, the following questions are addressed: how do local systems evolve in the process of de-localisation of productions? Which are the short term and long term effects to be expected? Can we interpret these processes under the light of changing specialization of economic systems, necessarily associated with gains from trade? Evidence is provided on the internationalization of manufacturing activities that are commonly identified as “made in Italy”, with specific reference to the textile and footwear industries. The focus will be on the re-organization of economic activities at the level of local systems specialized in these industries, rather than on individual firms; on the whole set of international operations involved in this process, regardless of the legal form adopted (FDIs, import-export, cooperative agreements and licensing); and on how changes in the international organisation of production in these industries are associated with changes in the economic performances within these industries as well as in related sectors, such as service industries.Foreign Direct Investments,Import-export cooperative agreements, Licensing.

The Grand Sobolev Homeomorphisms and Their Measurability Properties

Abstract We study the validity of the condition (N) of Lusin for homeomorphisms under minimal assumptions on the integrability of Df. It turns out that the role of grand Sobolev spaces W1,n) and Wb 1,n) is crucial. A discussion of bi-Sobolev maps in the plane and their connections with degenerate elliptic PDEs is provided

Small fragments sodium sulfated hyaluronate, more than hyaluronic acid, reduces LPS-induced cytokine/chemokine levels in HaCaT cells

Hyaluronic acid (HA) is a linear non-sulphated glycosaminoglycan, used in dermatology as a biomaterial for bioengineering purposes, temporary dermal filler, stimulation of wound healing as well as drug vehicle in topical formulations. In addition to the well-characterized structural properties, extensive research on HA has revealed a range of vastly immunemodulatory effects, dependent on its size. In this in vitro study we investigated the ability of HA-S3, a small fragment HA (MW, molecular weight: 68 kDa) with degree of sulphatation of 3 and of HA fraction (MW:210 kDa) to reduce the bacterial induced inflammatory response in spontaneous immortalized keratinocytes. To this purpose, HaCaT cells were treated for 24 hours with 25 µg/ml of E. Coli derived bacterial lipopolysaccharide (LPS) in absence or presence of small fragment HA-S3 or HA. Cell viability was thereafter assessed using trypan blue stain and interleukin (IL)-8, IL-1β and tumor necrosis factor alpha (TNF-α) concentrations were determined in cell supernatants by single enzyme-linked immunoadsorbent assay (ELISA). Our results showed that cell viability was not affected either by HA-S3 or HA which in turn were able to reduce LPS-induced mortality. HA and especially HA-S3 were able to significantly reduce LPS-induced pro-inflammatory cytokines. Our observation might suggest new perspectives in the development of HA-S3 containing topical products able to modulate cutaneous inflammatory response

A geoarchaeological study of the metaponto coastal belt, southern Italy, based on geomorphological mapping and gis-supported classification of landforms

In this work we tried to infer the settlement rules and archaeological site patterns in pilot coastal area with high “archaeological potential” through the analysis of the spatial relationships between landform unit maps deriving from a GIS-supported procedure of landform extraction integrated with geomorphological analyses and archaeological evidence. This approach has been tested in the coastal Ionian sector of the Basilicata region, where a detailed geoarchaeological research has been carried out in the frame of the multidisciplinary MeTIBas project (the Italian acronyms for Innovative Methods and Technologies for the Cultural Heritages in the Basilicata region), funded by the European Community. The study area extends on the southernmost part of the Bradano Foredeep, southern Italy, and roughly coincides with the Greek settlement territory of Metaponto and its Chora (the area of influence of Greek colonists). Archaeological investigations, regarding about 1400 sites, consisted of a re-examination of literature data and new field surveys. The relationships between landscape elements deriving from the procedure here proposed and archaeological sites have been statistically investigated to derive settlement patterns and rules. Results highlight a preferential distribution of the identified categories of archaeological sites on gently-dipping marine terrace surfaces and near their edges, thus implying that settlement dynamics of the Metaponto territory partially driven by the topographic position

Comparison of Baseline Characteristics and Outcomes in Men Versus Women With Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation

Female gender has been linked to increased risk of adverse events after surgical aortic valve replacement; however, the evidence regarding the role of gender differences on clinical outcomes in patients who underwent transcatheter aortic valve implantation (TAVI) is still debated. This retrospective study included 910 consecutive patients with severe, symptomatic aortic stenosis who underwent TAVI in 2 institutions from January 2012 to July 2016. The primary end point was all-cause mortality at 1 year after TAVI in women versus men. Women had a higher incidence of in-hospital vascular complications (7.8% vs 4.1%) and major or life-threatening bleeding (4.0% vs 1.6%) than men. At 1 year, women showed a lower mortality rate than men (7.0% vs 12.7%, adjusted hazard ratio [HR] 0.42, 95% confidence interval [CI] [0.23 to 0.76], p = 0.004). When stratifying by specific subgroups of interest, the survival benefit in women persisted in (1) patients with a Society of Thoracic Surgery risk score ≤ 8 (adjusted HR 0.35, 95% CI [0.14 to 0.88], p = 0.026); (2) patients treated with first-generation devices (adjusted HR 0.46, 95% CI [0.24 to 0.86], p = 0.016); and (3) patients treated with balloon-expandable valves (adjusted HR 0.40, 95% CI [0.19 to 0.86], p = 0.019). In conclusion, in this large patient cohort, women had lower 1-year mortality after TAVI than men, particularly with an STS score ≤ 8, or treated with first-generation and balloon-expandable devices

Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent

A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the leader peptide at the N-terminus. These results were fully confirmed by the molecular mass of rMnSOD as evaluated by ES/MS analysis (26662.7 Da) and the nucleotide sequence of the MnSOD cDNA. The role of the leader peptide in rMnSOD was investigated using a fluorescent and/or 68Gallium-labelled synthetic peptide. The labelled peptide permeated MCF-7 cells and uptake could be inhibited in the presence of an excess of oestrogen. In vivo it was taken up by the tumour, suggesting that the molecule can be used for both therapy and diagnosis. The in vitro and in vivo pharmacology tests confirmed that rMnSOD is only oncotoxic for tumour cells expressing oestrogen receptors. Pharmacokinetic studies in animals performed with 125I- and 131I-labelled proteins confirmed that, when administered systemically, rMnSOD selectively reached the tumour, where its presence was unambiguously demonstrated by scintigraphic and PET scans. PCR analysis revealed that Bax gene expression was increased and the Bcl2 gene was down regulated in MCF7 cells treated with rMnSOD, which suggests that the protein induces a pro-apoptotic mechanism