A Systematic Investigation of Light Heavy-Ion Reactions

We introduce a novel coupling potential for the scattering of deformed light heavy-ion reactions. This new approach is based on replacing the usual first-derivative coupling potential by a new, second derivative coupling potential in the coupled-channels formalism. The new approach has been successfully applied to the study of the $^{12}$C+$^{12}$C, $^{12}$C+$^{24}$Mg, $^{16}$O+$^{28}$Si and $^{16}$O+$^{24}$Mg systems and made major improvements over all the previous coupled-channels calculations for these systems. This paper also shows the limitations of the standard coupled-channels theory and presents a global solution to the problems faced in the previous theoretical accounts of these reactions.Comment: 7 pages with 4 figure

Melting of crystalline solids

It is suggested that at the melting temperature the thermal phonon vibration is in self-resonance with the lattice vibration of the surface atomic/molecular layer. This self resonance occurs at a well defined temperature and triggers the detachment of the atomic/molecular sheet or platelets from the surface of the crystal. Thermodynamic data of five substances is used to test this hypothesis. The calculated average phonon vibrational wavelengths are equal with or harmonics of the d-spacing of the atomic/molecular sheets. The proposed model is able to explain all of the features of melting.Comment: supercooling and ultra-fast speed of the phase transition is added as requirements for the explanation of meltin

A Global Potential Analysis of the 16^{16}O+28^{28}Si Reaction Using a New Type of Coupling Potential

A new approach has been used to explain the experimental data for the $^{16}$O+$^{28}$Si system over a wide energy range in the laboratory system from 29.0 to 142.5 MeV. A number of serious problems has continued to plague the study of this system for a couple of decades. The explanation of anomalous large angle scattering data; the reproduction of the oscillatory structure near the Coulomb barrier; the out-of-phase problem between theoretical predictions and experimental data; the consistent description of angular distributions together with excitation functions data are just some of these problems. These are long standing problems that have persisted over the years and do represent a challenge calling for a consistent framework to resolve these difficulties within a unified approach. Traditional frameworks have failed to describe these phenomena within a single model and have so far only offered different approaches where these difficulties are investigated separately from one another. The present work offers a plausible framework where all these difficulties are investigated and answered. Not only it improves the simultaneous fits to the data of these diverse observables, achieving this within a unified approach over a wide energy range, but it departs for its coupling potential from the standard formulation. This new feature is shown to improve consistently the agreement with the experimental data and has made major improvement on all the previous coupled-channels calculations for this system.Comment: 21 pages with 12 figure

New Results in the Analysis of the 16^{16}O+28^{28}Si Elastic Scattering by Modifying the Optical Potential

The elastic scattering of the $^{16}$O+$^{28}$Si system has been analyzed with a modified potential within the framework of the optical model over a wide energy range in the laboratory system from 29.0 to 142.5 MeV. This system has been extensively studied over the years and a number of serious problems has remained unsolved: The explanation of the anomalous large angle scattering data; the out-of-phase problem between theoretical predictions and experimental data; the reproduction of the oscillatory structure near the Coulomb barrier; the consistent description of angular distributions together with the excitation functions data are just some of these problems. We propose the use of a modified potential method to explain these problems over this wide energy range. This new method consistently improves the agreement with the experimental data and achieves a major improvement on all the previous Optical model calculations for this system.Comment: 19 pages with 8 figure

Dynein Function and Protein Clearance Changes in Tumor Cells Induced by a Kunitz-Type Molecule, Amblyomin-X

Amblyomin-X is a Kunitz-type recombinant protein identified from the transcriptome of the salivary glands of the tick Amblyomma cajennense and has anti-coagulant and antitumoral activity. the supposed primary target of this molecule is the proteasome system. Herein, we elucidated intracellular events that are triggered by Amblyomin-X treatment in an attempt to provide new insight into how this serine protease inhibitor, acting on the proteasome, could be comparable with known proteasome inhibitors. the collective results showed aggresome formation after proteasome inhibition that appeared to occur via the non-exclusive ubiquitin pathway. Additionally, Amblyomin-X increased the expression of various chains of the molecular motor dynein in tumor cells, modulated specific ubiquitin linkage signaling and inhibited autophagy activation by modulating mTOR, LC3 and AMBRA1 with probable dynein involvement. Interestingly, one possible role for dynein in the mechanism of action of Amblyomin-X was in the apoptotic response and its crosstalk with autophagy, which involved the factor Bim; however, we observed no changes in the apoptotic response related to dynein in the experiments performed. the characteristics shared among Amblyomin-X and known proteasome inhibitors included NF-kappa B blockage and nascent polypeptide-dependent aggresome formation. Therefore, our study describes a Kunitz-type protein that acts on the proteasome to trigger distinct intracellular events compared to classic known proteasome inhibitors that are small-cell-permeable molecules. in investigating the experiments and literature on Amblyomin-X and the known proteasome inhibitors, we also found differences in the structures of the molecules, intracellular events, dynein involvement and tumor cell type effects. These findings also reveal a possible new target for Amblyomin-X, i.e., dynein, and may serve as a tool for investigating tumor cell death associated with proteasome inhibition.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Butantan Inst, Biochem & Biophys Lab, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biochem, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biochem, São Paulo, BrazilFAPESP: 2011/05969-4FAPESP: CAT/CEPID 1998/14307-9FAPESP: CETICs 2013/07467-1Web of Scienc

¿Algo de la esencia del ser resuena como (objeto) voz en el pasador?

Lo que aquí se propone el autor será un armado, un recorrido, una puesta en relación del marco teórico del Dispositivo del Pase, con lo que le debemos a la experiencia psicoanalítica y el material testimonial de Pasadores, nominados con el título de Analistas de Escuela y Carteles, con el objetivo de establecer una correlación posible entre este dispositivo y el proceso analítico, destacando en ese cruce la importancia de la voz como objeto a. En el Dispositivo del Pase se trataría de cernir un saber correlativo a un cambio de posición del candidato en relación al saber, cierta certeza del encuentro con ese saber, junto a la caída del sujeto supuesto al saber, lo que determina el ingreso a la operación del Pase.Eje temático: PsicoanálisisFacultad de Psicologí

Processamento de Titanato de Cobre e Cálcio (CCTO) Pelo Método dos Precursores Poliméricos para Aplicação em Dispositivos Fotoluminescentes.

Cerâmicas a base de CaCu₃Ti₄O₁₂ (CCTO) têm despertado grande interesse científico e tecnológico após a descoberta da sua elevada constante dielétrica. Uma outra propriedade dos titanatos e sua característica óptica que tem despertando grande interesse entre os pesquisadores. Neste projeto de pesquisa, obteve-se pós cerâmicos CCTO pelo método dos precursores poliméricos (Pechini) com propriedade fotoluminescente em função do grau de ordem e desordem dos pós-processados. Os pós-obtidos após processamento foram caracterizados por: termogravimetria, para verificar as faixas de temperatura em que o material processado tem perda de massa; difração de raios-X, para determinar a estrutura cristalográfica e estimar os tipos de defeitos desenvolvidos; espectroscopia no infravermelho com transformada de Fourier, para analisar os diferentes modos de vibração apresentados pelo material; espectroscopia Raman, para caracterizar e identificar as unidades estruturais do material e fotoluminescência para constatar a validade do método na obtenção de compostos que possam ser utilizados como dispositivos luminescentes

¿Algo de la esencia del ser resuena como (objeto) voz en el pasador?

Lo que aquí se propone el autor será un armado, un recorrido, una puesta en relación del marco teórico del Dispositivo del Pase, con lo que le debemos a la experiencia psicoanalítica y el material testimonial de Pasadores, nominados con el título de Analistas de Escuela y Carteles, con el objetivo de establecer una correlación posible entre este dispositivo y el proceso analítico, destacando en ese cruce la importancia de la voz como objeto a. En el Dispositivo del Pase se trataría de cernir un saber correlativo a un cambio de posición del candidato en relación al saber, cierta certeza del encuentro con ese saber, junto a la caída del sujeto supuesto al saber, lo que determina el ingreso a la operación del Pase.Eje temático: PsicoanálisisFacultad de Psicologí

Morphological Evidence for an Oral Venom System in Caecilian Amphibians

Amphibians are known for their skin rich in glands containing toxins employed in passive chemical defense against predators, different from, for example, snakes that have active chemical defense, injecting their venom into the prey. Caecilians (Amphibia, Gymnophiona) are snake-shaped animals with fossorial habits, considered one of the least known vertebrate groups. We show here that amphibian caecilians, including species from the basal groups, besides having cutaneous poisonous glands as other amphibians do, possess specific glands at the base of the teeth that produce enzymes commonly found in venoms. Our analysis of the origin of these glands shows that they originate from the same tissue that gives rise to teeth, similar to the venom glands in reptiles. We speculate that caecilians might have independently developed mechanisms of production and injection of toxins early in their evolutionary history

Observation of initial clinical manifestations and repercussions from the treatment of 314 human injuries caused by black sea urchins (Echinometra lucunter) on the southeastern Brazilian coast

INTRODUCTION: Injuries caused by sea urchins are the most common caused by marine animals in humans in Brazil, with the black sea urchin (Echinometra lucunter) causing the most injuries to bathers. METHODS: This study observed 314 human wounds with emphasis on the early observation of clinical signs and symptoms and their implications on the recommended treatment. RESULTS: All the injuries were caused by black sea urchins and were observed in bathers. The lesions and the pain were associated with penetration of the spines; there was no early inflammation or pain without pressure on the wounded places. Complications arising from this kind on injury, including infections and foreign body granulomas, are associated with the permanence of the spines in the wounds. CONCLUSIONS: The study confirmed that this kind of injury is the most common accident caused by aquatic animals in Brazil. The main therapeutical recommendation is early removal of the spines to prevent late complications, such as infections and the formation of foreign body granulomas