A sound education: using podcasts to develop study skills

Coping with the demands of academic study at university level can be a challenging experience for many students, and effective study skills are crucial in achieving academic success. However, librarians and teachers in higher education will know that it is not always easy to engage students in developing their study skills. How can we find new ways of stimulating the interest of our students? An innovative approach to teaching and the exploitation of new technologies can provide solutions and ideas. Podcasting has been very popular in recent years for delivering entertainment, news and other information, but podcasts are also extensively used in education, enabling students to watch or listen at a time that suits them – at home, at work or while travelling. The Skills for learning website was established over ten years ago as part of the library service at Leeds Metropolitan University to support the teaching and learning of study skills. The website offers students a wide range of resources including topics such as academic writing, time management, group skills, reflection and how to do research. There is also a team of tutors who provide workshops and tutorials. We felt that a podcast series could provide an alternative and flexible way of delivering study skills support that might appeal to a new audience. The podcasts could also be used as a stimulus in classroom teaching. As they are usually released episodically, we hoped that subscribers or visitors to our podcast page would become ‘hooked’ on the series and want to tune in to future podcasts. All the podcasts were created in-house by members of the Skills for learning team

When the game becomes serious: what are the rights and responsibilities of the learner’s avatar in the virtual world?

“I am my avatar; my avatar is me. I am beholden by any promises my Avatar makes on my behalf and my Avatar will honour any contract I make.” There is an ever-increasing use of virtual worlds such as Second Life™, OpenSim and SmallWorlds in which learners explore, experience, communicate and act. In these 3D immersive (3Di) environments the learner adopts an avatar and becomes the new persona they devise. The appearance, actions and location of the avatar are under the control of the owner but are also affected by objects in the environment and other avatars. The immersive element results directly from the cognitive, dextrous, social and emotional aspects of the experience. Virtual worlds are becoming the home for serious learning as well as still retaining their more vicarious activities<br/

Indecomposable summands of Foulkes modules

In this paper we study the modular structure of the permutation module $H^{(2^n)}$ of the symmetric group $S_{2n}$ acting on set partitions of a set of size $2n$ into $n$ sets each of size $2$, defined over a field of odd characteristic $p$. In particular we characterize the vertices of the indecomposable summands of $H^{(2^n)}$ and fully describe all of its indecomposable summands that lie in blocks of $p$-weight at most two. When $2n < 3p$ we show that there is a unique summand of $H^{(2^n)}$ in the principal block of $S_{2n}$ and that this summand exhibits many of the extensions between simple modules in its block.Comment: 21 pages, 5 figure

Solution of the structure of tetrameric human glucose 6-phosphate dehydrogenase by molecular replacement

Recombinant human glucose 6-phosphate dehydrogenase (G6PD) has been crystallized and its structure solved by molecular replacement. Crystals of the natural mutant R459L grow under similar conditions in space groups P212121 and C2221 with eight or four 515-residue molecules in the asymmetric unit, respectively. A non-crystallographic 222 tetramer was found in the C2221 crystal form using a 4 A resolution data set and a dimer of the large beta + alpha domains of the Leuconostoc mesenteroides enzyme as a search model. This tetramer was the only successful search model for the P212121 crystal form using data to 3 A. Crystals of the deletion mutant DeltaG6PD grow in space group F222 with a monomer in the asymmetric unit; 2.5 A resolution data have been collected. Comparison of the packing of tetramers in the three space groups suggests that the N-terminal tail of the enzyme prevents crystallization with exact 222 molecular symmetry.published_or_final_versio

Learning archetypes as tools of Cybergogy for a 3D educational landscape: a structure for eTeaching in Second Life

This paper considers issues of validity and credibility of eTeaching using a 3D Virtual World as a delivery medium of eLearning pertaining to the transfer of authentic real life skills. It identifies the game like qualities perceived therein, recognising that these very attributes may, when experienced superficially, be a contributing factor to the potential educational demise of the platform. It goes on to examine traditional educational theories in the light of the affordances of a virtual world seeking to adapt and apply them to the construction of a new conceptual framework of a pedagogy reflecting the affordances and understanding of on-line learning which incorporates the implementation of Learning Archetypes (models of activities) to maximise the essence of a virtual world, in as much as it is able to facilitate learning experiences delimited by physical world constraints. It builds upon these ideas to develop a working model of Cybergogy and Learning Archetypes in 3D with a view to making it available to people who wish to demonstrate theoretically robust lesson and course planning. The model is then applied to three examples of eTeaching, developed as Case Studies for the purpose of critically evaluating the model, which is found to be operationally effective, accurate and flexible. Conclusions are drawn that identify the merits and challenges of implementing such a model of Cybergogy into eTeaching and eLearning conducted in Second Life®

Quantitative data analysis of perceived barriers and motivators to physical activity in stroke survivors

Peer reviewedPublisher PD

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology

Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is unknown. To study this issue, here we develop a model of human central metabolism that incorporates a solvent capacity constraint of metabolic enzymes and mitochondria, accounting for their occupied volume densities, while assuming glucose and/or fatty acid utilization. The model demonstrates that activation of aerobic glycolysis is favored above a threshold metabolic rate in both rapidly proliferating cells and heavily contracting muscles, because it provides higher ATP yield per volume density than mitochondrial oxidative phosphorylation. In the case of muscle physiology, the model also predicts that before the lactate switch, fatty acid oxidation increases, reaches a maximum, and then decreases to zero with concomitant increase in glucose utilization, in agreement with the empirical evidence. These results are further corroborated by a larger scale model, including biosynthesis of major cell biomass components. The larger scale model also predicts that in proliferating cells the lactate switch is accompanied by activation of glutaminolysis, another distinctive feature of the Warburg effect. In conclusion, intracellular molecular crowding is a fundamental constraint for cell metabolism in both rapidly proliferating- and non-proliferating cells with high metabolic demand. Addition of this constraint to metabolic flux balance models can explain several observations of mammalian cell metabolism under steady state conditions

Efficient replication bypass of size-expanded DNA base pairs in bacterial cells

Author Manuscript 2012 September 06Supersize me! Size-expanded DNA bases (xDNA) are able to encode natural DNA sequences in replication. In vitro experiments with a DNA polymerase show nucleotide incorporation opposite the xDNA bases with correct pairing. In vivo experiments using E. coli show that two xDNA bases (xA and xC, see picture) encode the correct replication partners.National Institutes of Health (U.S.) (CA80024)National Institutes of Health (U.S.) (GM63587)Stanford Graduate Fellowshi

Synthesis and Application of Dye-Ligand Affinity Adsorbents

Dye-ligand affinity chromatography is a widely used technique in protein purification. The utility of the reactive dyes as affinity ligands results from their unique chemistry, which confers wide specificity towards a large number of proteins. They are commercially available, are inexpensive, and can easily be immobilized. Important factors that contribute to the successful operation of a dye-ligand chromatography include adsorbent properties, such as matrix type and ligand concentration, the buffer conditions used in the adsorption and elution stages, and contacting parameters like flow rate and column geometry. In general, with dye-ligand affinity chromatography, the specificity is provided by the adsorption and elution conditions employed in a particular purification, and these must often be worked out by trial and error. The present chapter provides protocols for the synthesis of dye-ligand affinity adsorbents as well as protocols for screening, selection, and optimization of a dye-ligand purification step. The purification of the glutathione transferases from Phaseolus vulgaris crude extract on Cibacron Blue 3GA-Sepharose is given as an example