Carnegie Hubble Program: A Mid-Infrared Calibration of the Hubble Constant

Using a mid-infrared calibration of the Cepheid distance scale based on recent observations at 3.6 um with the Spitzer Space Telescope, we have obtained a new, high-accuracy calibration of the Hubble constant. We have established the mid-IR zero point of the Leavitt Law (the Cepheid Period-Luminosity relation) using time-averaged 3.6 um data for ten high-metallicity, Milky Way Cepheids having independently-measured trigonometric parallaxes. We have adopted the slope of the PL relation using time-averaged 3.6 um data for 80 long-period Large Magellanic Cloud (LMC) Cepheids falling in the period range 0.8 < log(P) < 1.8. We find a new reddening-corrected distance to the LMC of 18.477 +/- 0.033 (systematic) mag. We re-examine the systematic uncertainties in H0, also taking into account new data over the past decade. In combination with the new Spitzer calibration, the systematic uncertainty in H0 over that obtained by the Hubble Space Telescope (HST) Key Project has decreased by over a factor of three. Applying the Spitzer calibration to the Key Project sample, we find a value of H0 = 74.3 with a systematic uncertainty of +/-2.1 (systematic) km/s/Mpc, corresponding to a 2.8% systematic uncertainty in the Hubble constant. This result, in combination with WMAP7 measurements of the cosmic microwave background anisotropies and assuming a flat universe, yields a value of the equation of state for dark energy, w0 = -1.09 +/- 0.10. Alternatively, relaxing the constraints on flatness and the numbers of relativistic species, and combining our results with those of WMAP7, Type Ia supernovae and baryon acoustic oscillations yields w0 = -1.08 +/- 0.10 and a value of N_eff = 4.13 +/- 0.67, mildly consistent with the existence of a fourth neutrino species.Comment: 27 pages, 8 figures, Accepted for publication in Ap

The Carnegie Hubble Program: The Distance and Structure of the SMC as Revealed by Mid-infrared Observations of Cepheids

Using Spitzer observations of classical Cepheids we have measured the true average distance modulus of the SMC to be $18.96 \pm 0.01_{stat} \pm 0.03_{sys}$ mag (corresponding to $62 \pm 0.3$ kpc), which is $0.48 \pm 0.01$ mag more distant than the LMC. This is in agreement with previous results from Cepheid observations, as well as with measurements from other indicators such as RR Lyrae stars and the tip of the red giant branch. Utilizing the properties of the mid--infrared Leavitt Law we measured precise distances to individual Cepheids in the SMC, and have confirmed that the galaxy is tilted and elongated such that its eastern side is up to 20 kpc closer than its western side. This is in agreement with the results from red clump stars and dynamical simulations of the Magellanic Clouds and Stream.Comment: Accepted for publication in ApJ. 38 Pages, 11 figures. Figure 9 is interactive. Spitzer photometry for all Cepheids available as online tabl

Stripping of Acacia koa Bark by Rats on Hawaii and Maui

Koa (Acacia koa) is the most valuable native timber species in Hawaii. Bark stripping of young trees by rats, a common but unstudied phenomenon, may affect survival, growth, and quality of koa. Up to 54% of the trees sampled in 4- to 6-year-old stands in the Laupahoehoe and Waiakea areas on Hawaii were wounded by rats; only 5% of trees sampled in a l-year-old stand on Borge Ridge, Maui, were wounded. Wounds were generally long and narrow. Complete girdling was not observed, and direct mortality seemed low. However, indirect effects of damage-deformation of stems, infection by pathogens, and premature death-require further study. Because only young trees seem susceptible to bark stripping, rodent control may be desirable during the first 5 years of koa stand growth

The Carnegie Hubble Program

We present an overview of and preliminary results from an ongoing comprehensive program that has a goal of determining the Hubble constant to a systematic accuracy of 2%. As part of this program, we are currently obtaining 3.6 micron data using the Infrared Array Camera (IRAC) on Spitzer, and the program is designed to include JWST in the future. We demonstrate that the mid-infrared period-luminosity relation for Cepheids at 3.6 microns is the most accurate means of measuring Cepheid distances to date. At 3.6 microns, it is possible to minimize the known remaining systematic uncertainties in the Cepheid extragalactic distance scale. We discuss the advantages of 3.6 micron observations in minimizing systematic effects in the Cepheid calibration of the Hubble constant including the absolute zero point, extinction corrections, and the effects of metallicity on the colors and magnitudes of Cepheids. We are undertaking three independent tests of the sensitivity of the mid-IR Cepheid Leavitt Law to metallicity, which when combined will allow a robust constraint on the effect. Finally, we are providing a new mid-IR Tully-Fisher relation for spiral galaxies

The burden of chronic obstructive pulmonary disease associated with maintenance monotherapy in the UK

Susan C Edwards,1 Sian E Fairbrother,2 Anna Scowcroft,3 Gavin Chiu,4 Andrew Ternouth,3 Brian J Lipworth5 1Department of Market Access Pricing&nbsp;&amp; Outcomes Research, 2Department of Medical Affairs - Respiratory, 3Department of Market Access, 4Department of Prescription Medicine - Respiratory, Boehringer Ingelheim, Bracknell, UK; 5Asthma and Allergy Research Group, Division of Cardiovascular and Diabetes Medicine, Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK Background: This study characterized a cohort of chronic obstructive pulmonary disease (COPD) patients on maintenance bronchodilator monotherapy for &ge;6 months to establish their disease burden, measured by health care utilization.Methods: Data were extracted from the UK Clinical Practice Research Datalink and linked to Hospital Episode Statistics. The monotherapy period spanned the first prescription of a long-acting &beta;2-adrenergic agonist or a long-acting muscarinic antagonist until the end of the study (December 31, 2013) or until step up to dual/triple therapy, for example, addition of another long-acting bronchodilator, an inhaled corticosteroid, or both. A minimum of four consecutive prescriptions and 6 months on continuous monotherapy were required. Patients &lt;50 years old at first COPD diagnosis or with another significant respiratory disease before starting monotherapy were excluded. Disease burden was evaluated by measuring patients&rsquo; rate of face-to-face interactions with a health care professional (HCP), COPD-related exacerbations, hospitalizations, and referrals.Results: A cohort of 8,811 COPD patients (95% Global initiative for chronic Obstructive Lung Disease stage A/B) on maintenance monotherapy was identified between 2002 and 2013; 45% of these patients were still on monotherapy by the end of the study. Median time from first COPD diagnosis to first monotherapy prescription was 56 days, while the median time on maintenance bronchodilator monotherapy was 2 years. The median number of prescriptions was 14. On average, patients had 15 HCP interactions per year, and one in ten patients experienced a COPD exacerbation (N=8,811). One in 50 patients were hospitalized for COPD per year (n=4,848).Conclusion: The average monotherapy-treated patient had a higher than average HCP interaction rate. We also identified a large cohort of patients who were stepped up to triple therapy despite a low rate of exacerbations. The use of the new class of long-acting muscarinic antagonist/long-acting &beta;2-adrenergic agonist fixed-dose combinations may provide a useful step-up treatment option in such monotherapy patients, before the use of inhaled corticosteroids. Keywords: COPD, UK primary care setting, bronchodilators, prescribing patterns, monotherap

The Calibration of the WISE W1 and W2 Tully-Fisher Relation

In order to explore local large-scale structures and velocity fields, accurate galaxy distance measures are needed. We now extend the well-tested recipe for calibrating the correlation between galaxy rotation rates and luminosities -- capable of providing such distance measures -- to the all-sky, space-based imaging data from the Wide-field Infrared Survey Explorer (WISE) W1 ($3.4\mu$m) and W2 ($4.6\mu$m) filters. We find a linewidth to absolute magnitude correlation (known as the Tully-Fisher Relation, TFR) of $\mathcal{M}^{b,i,k,a}_{W1} = -20.35 - 9.56 (\log W^i_{mx} - 2.5)$ (0.54 magnitudes rms) and $\mathcal{M}^{b,i,k,a}_{W2} = -19.76 - 9.74 (\log W^i_{mx} - 2.5)$ (0.56 magnitudes rms) from 310 galaxies in 13 clusters. We update the I-band TFR using a sample 9% larger than in Tully & Courtois (2012). We derive $\mathcal{M}^{b,i,k}_I = -21.34 - 8.95 (\log W^i_{mx} - 2.5)$ (0.46 magnitudes rms). The WISE TFRs show evidence of curvature. Quadratic fits give $\mathcal{M}^{b,i,k,a}_{W1} = -20.48 - 8.36 (\log W^i_{mx} - 2.5) + 3.60 (\log W^i_{mx} - 2.5)^2$ (0.52 magnitudes rms) and $\mathcal{M}^{b,i,k,a}_{W2} = -19.91 - 8.40 (\log W^i_{mx} - 2.5) + 4.32 (\log W^i_{mx} - 2.5)^2$ (0.55 magnitudes rms). We apply an I-band -- WISE color correction to lower the scatter and derive $\mathcal{M}_{C_{W1}} = -20.22 - 9.12 (\log W^i_{mx} - 2.5)$ and $\mathcal{M}_{C_{W2}} = -19.63 - 9.11 (\log W^i_{mx} - 2.5)$ (both 0.46 magnitudes rms). Using our three independent TFRs (W1 curved, W2 curved and I-band), we calibrate the UNION2 supernova Type Ia sample distance scale and derive $H_0 = 74.4 \pm 1.4$(stat) $\pm\ 2.4$(sys) kms$^{-1}$ Mpc$^{-1}$ with 4% total error.Comment: 22 page, 21 figures, accepted to ApJ, Table 1 data at http://spartan.srl.caltech.edu/~neill/tfwisecal/table1.tx