Corynebacterium Pyogenes Infection in a Hereford Calf

A 5- weeks old hereford bull calf was admitted to the Stange Memorial Clinic on March 15, 1950, with the owner\u27s history of enlargements on the jaws since birth

Mammalian Ribosomal Precursor RNA

Both 18s and 28s ribosomal RNA in HeLa cells are transcribed in the nucleolus within a single large precursor RNA molecule (45S RNA) which is believed to contain, in addition to the ribosomal sequences, extensive non-ribosomal regions termed "transcribed spacers". Substantial segments of the transcribed spacer region are retained in the various nucleolar intermediates in maturation (41S, 32S and 20S RNA). Presented in this thesis are the results obtained from a direct analysis of transcribed spacer using RNA fingerprinting techniques with 32P-labelled RNA. 1. By comparing fingerprints of 28s RNA with its immediate precursor 32S RNA, I identified and characterised some 13 oligonucleotides which are present in 32S RNA only and which thus must be derived from the transcribed spacer region of 32S RNA. 2. Fingerprints of 45S RNA were compared with those of a mixture of 28s + 18s RNA and 9 distinctive transcribed spacer oligonucleotides were identified in addition to those from the 32S molecule. 3. By identifying specific 5-8S oligonucleotides in fingerprints of 32S and 45S RNA I was able to show that 5-8S RNA is transcribed as part of the 45S ribosomal precursor RNA molecule. 4. The primary sequence of transcribed spacer from HeLa ribosomal precursor RNA and L cell ribosomal precursor RNA was compared and found to be less highly conserved than the ribosomal sequences. All the above mentioned oligonucleotides are of potential value for further structural analysis and for determining the spacial arrangement of transcribed spacer and ribosomal sequences in 45S ribosomal precursor RNA

Analysis of visual demands in a transport category aircraft

Analysis of visual demands in a transport category aircraf

Distinguishing Marks: The Politics of the First Great Awakening

Few people spend much time thinking about the revivals of the 1700s on the American continent. Most Christians who do probably see the evangelical movement from about 1730 through the 1740s as a clear outpouring of God’s Spirit. In the heat of the moment, though, not all were convinced that the revivals were from God. The First Great Awakening challenged the traditional theology in the colonies, pushing boundaries and forcing churches to wrestle with new issues. The revivals started in local areas, but soon spread throughout the colonies. Without a doubt, the Great Awakening permanently altered the face of religion on this continent. The revivals brought out mixed reactions. Those who were in favor of the revivals were called New Lights, and those opposed to the movement Old Lights. This distinction between two groups remained mostly unquestioned in scholarship until Thomas Kidd’s The Great Awakening: The Roots of Evangelical Christianity in Colonial America. In this work, Kidd proposes a different grading method. Rather than a dyadic, two-ended scale, Kidd suggests that a continuum better fits the ideologies of the Awakening. The Old Lights are still the anti-revivalists, according to Kidd, but the New Lights are divided. In the New Light camp, the enthusiastic, entirely pro-revivalists would be radical evangelicals, while the cautious revivalists would be moderate evangelicals. Studying the era confirms Kidd’s theory, as it is clear that revivalists were not all in agreement

Daily Phonatory Activity of Individuals with Parkinson’s Disease

Purpose This study evaluated the amount of phonatory activity of Persons with Parkinson disease (PwPD) compared to adults without Parkinson’s disease measured over 3 days. The relationship between the amount of phonatory activity and Voice Handicap Index (VHI) total score was assessed as were differences in voicing activity across 3 days of data collection. Methods Fifteen PwPD receiving dopaminergic medication and fifteen age and sex matched adults without Parkinson’s disease completed the VHI and then wore a VocaLog vocal monitor (VM) for 3 consecutive days. From the VM data, the number of 1-second windows with dB sound pressure level \u3e 0 were summed as a measure of phonatory activity (PA) and reported relative to the time the VM was worn (%PA). Results The percentage of time the VM was worn did not differ between groups or across days. The PwPD had statistically significantly fewer minutes of PA per day than controls (F = 21.782, P \u3c 0.001) by 54 minutes on average. The %PA also differed significantly (F = 31.825, P \u3c 0.001) with a mean of 11.1% for PwPD and 18.6% for controls. Neither PA nor %PA differed across the 3 days of vocal monitoring. VHI total score was significantly correlated with PA (r = -0.436, P = 0.016) and %PA (r = -0.534, P = 0.002) for all participants. Conclusions The results indicate that PwPD engaged in less verbal communication in their daily environment compared to adults without Parkinson’s disease. The findings support reports in the literature indicating that PwPD often have reduced communication participation. Measures such as %PA could serve as a quantifiable metric in future studies assessing communication changes in PwPD as a function of disease progression or therapeutic interventions

Testing of the VocaLog Vocal Monitor

Objective. To elucidate capabilities and limitations of the VocaLog, a device marketed to log-calibrated dB sound pressure level (SPL). Study Design. The study design varied depending on the experiment. All were prospective. Some were case series, and others were cohort studies without controls. Method. Experiments were conducted to determine (1) whether the VocaLog logged phonatory activity and silence when it should, (2) if nonphonatory activities were detected, (3) correlation of VocaLog dB values to an external sound level meter (SLM), and (4) accuracy of phonation time (PT) and speaking time (ST) estimates from the VocaLog. Results. Silence and phonatory activity were logged as such nearly 100% of the time. Nonphonatory activities were sometimes detected as dB values, including coughs, throat clear, belching, and swallows. The dB values from the VocaLog were strongly correlated with dB SPL from an external SLM. When on the neck, the device rarely picked up external sounds when the external noise was between 85 and 103 dB SPL. The VocaLog gave a reasonable estimate of ST but overestimated PT. Conclusions. Overall, the VocaLog holds promise as means of indexing vocal loudness via calibrated dBSPL levels. However, some nonphonatory activity is also likely to be logged. The device provides a reasonable estimate of ST, but not PT

Human Rights Commissions and Public Policy: The Role of the Canadian Human Rights Commission in Advancing Sexual Orientation Equality Rights in Canada

Carleton College does not own the copyright to this work and the work is available through the Carleton College Library following the original publisher\u27s policies regarding self-archiving. For more information on the copyright status of this work, refer to the current copyright holder

Tolerance of the VocaLog Vocal Monitor by Healthy Persons and Individuals With Parkinson Disease

Objective: To assess subject tolerance of extended use of the VocaLogTM vocal monitor (VM), a device marketed to log calibrated decibel sound pressure level. Study Design: Prospective between-subjects design including two age- and sex-matched groups: individuals with Parkinson disease (IWPD) and healthy persons. Methods: After an initial session to calibrate the device and demonstrate its use, participants wore the VM during waking hours for five consecutive days. At a second visit to return the VM, participants completed a survey and a short interview regarding their experience with and perceptions of the device. Results: Those with PD and control subjects reported relatively few issues with use of the VM. There were no group differences regarding convenience, others’ reactions, technical issues, or future participation in similar studies. Participants with PD indicated similar frequency of discomfort issues but higher severity ratings for discomfort during VM use compared with healthy participants. Conclusions: The VocaLogTM offers a method to monitor vocal loudness during everyday activities for several consecutive days. The device was well tolerated by participants from both groups. IWPD reported greater discomfort than controls, possibly reflecting altered sensory perceptions associated with PD. The current data offer some reassurance that this VM can be tolerated by both healthy persons and those with PD for clinical and research purposes