110 research outputs found
Is it the boundaries or disorder that dominates electron transport in semiconductor `billiards'?
Semiconductor billiards are often considered as ideal systems for studying
dynamical chaos in the quantum mechanical limit. In the traditional picture,
once the electron's mean free path, as determined by the mobility, becomes
larger than the device, disorder is negligible and electron trajectories are
shaped by specular reflection from the billiard walls alone. Experimental
insight into the electron dynamics is normally obtained by magnetoconductance
measurements. A number of recent experimental studies have shown these
measurements to be largely independent of the billiards exact shape, and highly
dependent on sample-to-sample variations in disorder. In this paper, we discuss
these more recent findings within the full historical context of work on
semiconductor billiards, and offer strong evidence that small-angle scattering
at the sub-100 nm length-scale dominates transport in these devices, with
important implications for the role these devices can play for experimental
tests of ideas in quantum chaos.Comment: Submitted to Fortschritte der Physik for special issue on Quantum
Physics with Non-Hermitian Operator
The New Look pMSSM with Neutralino and Gravitino LSPs
The pMSSM provides a broad perspective on SUSY phenomenology. In this paper
we generate two new, very large, sets of pMSSM models with sparticle masses
extending up to 4 TeV, where the lightest supersymmetric particle (LSP) is
either a neutralino or gravitino. The existence of a gravitino LSP necessitates
a detailed study of its cosmological effects and we find that Big Bang
Nucleosynthesis places strong constraints on this scenario. Both sets are
subjected to a global set of theoretical, observational and experimental
constraints resulting in a sample of \sim 225k viable models for each LSP type.
The characteristics of these two model sets are briefly compared. We confront
the neutralino LSP model set with searches for SUSY at the 7 TeV LHC using both
the missing (MET) and non-missing ET ATLAS analyses. In the MET case, we employ
Monte Carlo estimates of the ratios of the SM backgrounds at 7 and 8 TeV to
rescale the 7 TeV data-driven ATLAS backgrounds to 8 TeV. This allows us to
determine the pMSSM parameter space coverage for this collision energy. We find
that an integrated luminosity of \sim 5-20 fb^{-1} at 8 TeV would yield a
substantial increase in this coverage compared to that at 7 TeV and can probe
roughly half of the model set. If the pMSSM is not discovered during the 8 TeV
run, then our model set will be essentially void of gluinos and lightest first
and second generation squarks that are \lesssim 700-800 GeV, which is much less
than the analogous mSUGRA bound. Finally, we demonstrate that non-MET SUSY
searches continue to play an important role in exploring the pMSSM parameter
space. These two pMSSM model sets can be used as the basis for investigations
for years to come.Comment: 54 pages, 22 figures; typos fixed, references adde
Low Prevalence of Conjunctival Infection with Chlamydia trachomatis in a Treatment-Naïve Trachoma-Endemic Region of the Solomon Islands
Trachoma is endemic in several Pacific Island states. Recent surveys across the Solomon Islands indicated that whilst trachomatous inflammation-follicular (TF) was present at levels warranting intervention, the prevalence of trachomatous trichiasis (TT) was low. We set out to determine the relationship between chlamydial infection and trachoma in this population. We conducted a population-based trachoma prevalence survey of 3674 individuals from two Solomon Islands provinces. Participants were examined for clinical signs of trachoma. Conjunctival swabs were collected from all children aged 1-9 years. We tested swabs for Chlamydia trachomatis (Ct) DNA using droplet digital PCR. Chlamydial DNA from positive swabs was enriched and sequenced for use in phylogenetic analysis. We observed a moderate prevalence of TF in children aged 1-9 years (n = 296/1135, 26.1%) but low prevalence of trachomatous inflammation-intense (TI) (n = 2/1135, 0.2%) and current Ct infection (n = 13/1002, 1.3%) in children aged 1-9 years, and TT in those aged 15+ years (n = 2/2061, 0.1%). Ten of 13 (76.9%) cases of infection were in persons with TF or TI (p = 0.0005). Sequence analysis of the Ct-positive samples yielded 5/13 (38%) complete (>95% coverage of reference) genome sequences, and 8/13 complete plasmid sequences. Complete sequences all aligned most closely to ocular serovar reference strains. The low prevalence of TT, TI and Ct infection that we observed are incongruent with the high proportion of children exhibiting signs of TF. TF is present at levels that apparently warrant intervention, but the scarcity of other signs of trachoma indicates the phenotype is mild and may not pose a significant public health threat. Our data suggest that, whilst conjunctival Ct infection appears to be present in the region, it is present at levels that are unlikely to be the dominant driving force for TF in the population. This could be one reason for the low prevalence of TT observed during the study
Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study
Background
Stratifying risk of postoperative pulmonary complications after major abdominal surgery allows clinicians to modify risk through targeted interventions and enhanced monitoring. In this study, we aimed to identify and validate prognostic models against a new consensus definition of postoperative pulmonary complications.
Methods
We did a systematic review and international external validation cohort study. The systematic review was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched MEDLINE and Embase on March 1, 2020, for articles published in English that reported on risk prediction models for postoperative pulmonary complications following abdominal surgery. External validation of existing models was done within a prospective international cohort study of adult patients (≥18 years) undergoing major abdominal surgery. Data were collected between Jan 1, 2019, and April 30, 2019, in the UK, Ireland, and Australia. Discriminative ability and prognostic accuracy summary statistics were compared between models for the 30-day postoperative pulmonary complication rate as defined by the Standardised Endpoints in Perioperative Medicine Core Outcome Measures in Perioperative and Anaesthetic Care (StEP-COMPAC). Model performance was compared using the area under the receiver operating characteristic curve (AUROCC).
Findings
In total, we identified 2903 records from our literature search; of which, 2514 (86·6%) unique records were screened, 121 (4·8%) of 2514 full texts were assessed for eligibility, and 29 unique prognostic models were identified. Nine (31·0%) of 29 models had score development reported only, 19 (65·5%) had undergone internal validation, and only four (13·8%) had been externally validated. Data to validate six eligible models were collected in the international external validation cohort study. Data from 11 591 patients were available, with an overall postoperative pulmonary complication rate of 7·8% (n=903). None of the six models showed good discrimination (defined as AUROCC ≥0·70) for identifying postoperative pulmonary complications, with the Assess Respiratory Risk in Surgical Patients in Catalonia score showing the best discrimination (AUROCC 0·700 [95% CI 0·683–0·717]).
Interpretation
In the pre-COVID-19 pandemic data, variability in the risk of pulmonary complications (StEP-COMPAC definition) following major abdominal surgery was poorly described by existing prognostication tools. To improve surgical safety during the COVID-19 pandemic recovery and beyond, novel risk stratification tools are required.
Funding
British Journal of Surgery Society
Migratory Bird Conservation Account – Increase the sales price for Duck Stamps from 25
beginning in 2011. The anticipated increase in sales receipts for FY 2011 would be approximately 15 to 58.0 million. With the additional receipts, the Service anticipates acquisition of approximately 7,000 additional acres in fee and approximately 10,000 additional conservation easement acres in 2011. Total acres acquired for 2011 would then be approximately 28,000 acres in fee title and 47,000 acres in perpetual conservation easements
An Empirical Analysis of Public Enforcement of Directorss Duties in Australia: Preliminary Findings
- …
