Reframing Kurtz’s Painting: Colonial Legacies and Minority Rights in Ethnically Divided Societies

Minority rights constitute some of the most normatively and economically important human rights. Although the political science and legal literatures have proffered a number of constitutional and institutional design solutions to address the protection of minority rights, these solutions are characterized by a noticeable neglect of, and lack of sensitivity to, historical processes. This Article addresses that gap in the literature by developing a causal argument that explains diverging practices of minority rights protections as functions of colonial governments’ variegated institutional practices with respect to particular ethnic groups. Specifically, this Article argues that in instances where colonial governments politicize and institutionalize ethnic hegemony in the pre-independence period, an institutional legacy is created that leads to lower levels of minority rights protections. Conversely, a uniform treatment and depoliticization of ethnicity prior to independence ultimately minimizes ethnic cleavages post-independence and consequently causes higher levels of minority rights protections. Through a highly structured comparative historical analysis of Botswana and Ghana, this Article builds on a new and exciting research agenda that focuses on the role of long-term historio-structural and institutional influences on human rights performance and makes important empirical contributions by eschewing traditional methodologies that focus on single case studies that are largely descriptive in their analyses. Ultimately, this Article highlights both the strength of a historical approach to understanding current variations in minority rights protections and the varied institutional responses within a specific colonial government

Peroneal artery pseudoaneurysm--a case report and literature review.

BACKGROUND: Aneurysms of the peroneal artery are infrequent and consist mainly of pseudoaneurysms. CASE PRESENTATION: This report describes an unusual case of peroneal pseudoaneurysm developing after thromoboembolectomy with a Fogarty catheter. It was managed successfully using an endovascular technique consisting of selective catheterization and coil embolization. The coils were placed in the peroneal artery, both proximal and distal to the pseudoaneurysm. CONCLUSION: Endovascular technique can be successfully used to treat pseudoaneurysms in difficult settings.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Invalid party wall awards and how to avoid them

Considers the reasons for the invalidity of party wall awards. Examines decided cases under earlier party wall legislation in the context of the Party Wall etc. Act 1996. Explains invalidity on the basis of an excess of the surveyors’ statutory authority. Defines this authority in terms of jurisdiction and power. Demonstrates the limits of the surveyors’ authority and emphasises the importance of strict compliance with statutory procedures. Concludes that surveyors should adopt an inquisitive and analytical approach to the scope of their authority to avoid the possibility of invalid awards. Echoes John Anstey’s earlier warning that surveyors should avoid a broad-brush approach to their duties which will only leave them “covered in soot”

Geographically weighted evidence combination approaches for combining discordant and inconsistent volunteered geographical information

There is much interest in being able to combine crowdsourced data. One of the critical issues in information sciences is how to combine data or information that are discordant or inconsistent in some way. Many previous approaches have taken a majority rules approach under the assumption that most people are correct most of the time. This paper analyses crowdsourced land cover data generated by the Geo-Wiki initiative in order to infer the land cover present at locations on a 50 km grid. It compares four evidence combination approaches (Dempster Shafer, Bayes, Fuzzy Sets and Possibility) applied under a geographically weighted kernel with the geographically weighted average approach applied in many current Geo-Wiki analyses. A geographically weighted approach uses a moving kernel under which local analyses are undertaken. The contribution (or salience) of each data point to the analysis is weighted by its distance to the kernel centre, reflecting Tobler’s 1st law of geography. A series of analyses were undertaken using different kernel sizes (or bandwidths). Each of the geographically weighted evidence combination methods generated spatially distributed measures of belief in hypotheses associated with the presence of individual land cover classes at each location on the grid. These were compared with GlobCover, a global land cover product. The results from the geographically weighted average approach in general had higher correspondence with the reference data and this increased with bandwidth. However, for some classes other evidence combination approaches had higher correspondences possibly because of greater ambiguity over class conceptualisations and / or lower densities of crowdsourced data. The outputs also allowed the beliefs in each class to be mapped. The differences in the soft and the crisp maps are clearly associated with the logics of each evidence combination approach and of course the different questions that they ask of the data. The results show that discordant data can be combined (rather than being removed from analysis) and that data integrated in this way can be parameterised by different measures of belief uncertainty. The discussion highlights a number of critical areas for future research

Breakdown of the semiclassical approximation during the early stages of preheating

The validity of the semiclassical approximation is investigated during the preheating phase in models of chaotic inflation using a modification of a criterion previously proposed for semiclassical gravity. If the modified criterion is violated then fluctuations of the two-point function for the quantum elds are large and the semiclassical approximation is not valid. Evidence is provided that the semiclassical approximation breaks down during the early stages of preheating, well before either scattering effects or backreaction effects are important

Open String Wavefunctions in Warped Compactifications

We analyze the wavefunctions for open strings in warped compactifications, and compute the warped Kahler potential for the light modes of a probe D-brane. This analysis not only applies to the dynamics of D-branes in warped backgrounds, but also allows to deduce warping corrections to the closed string Kahler metrics via their couplings to open strings. We consider in particular the spectrum of D7-branes in warped Calabi-Yau orientifolds, which provide a string theory realizations of the Randall-Sundrum scenario. We find that certain background fluxes, necessary in the presence of warping, couple to the fermionic wavefunctions and qualitatively change their behavior. This modified dependence of the wavefunctions are needed for consistency with supersymmetry, though it is present in non-supersymmetric vacua as well. We discuss the deviations of our setup from the RS scenario and, as an application of our results, compute the warping corrections to Yukawa couplings in a simple model. Our analysis is performed both with and without the presence of D-brane world-volume flux, as well as for the case of backgrounds with varying dilaton.Comment: 52 pages, refs. added, minor correction

Optimising the chick chorioallantoic membrane xenograft model of neuroblastoma for drug delivery

Background Neuroblastoma is a paediatric cancer that despite multimodal therapy still has a poor outcome for many patients with high risk tumours. Retinoic acid (RA) promotes differentiation of some neuroblastoma tumours and cell lines, and is successfully used clinically, supporting the view that differentiation therapy is a promising strategy for treatment of neuroblastoma. To improve treatment of a wider range of tumour types, development and testing of novel differentiation agents is essential. New pre-clinical models are therefore required to test therapies in a rapid cost effective way in order to identify the most useful agents. Methods As a proof of principle, differentiation upon ATRA treatment of two MYCN-amplified neuroblastoma cell lines, IMR32 and BE2C, was measured both in cell cultures and in tumours formed on the chick chorioallantoic membrane (CAM). Differentiation was assessed by 1) change in cell morphology, 2) reduction in cell proliferation using Ki67 staining and 3) changes in differentiation markers (STMN4 and ROBO2) and stem cell marker (KLF4). Results were compared to MLN8237, a classical Aurora Kinase A inhibitor. For the in vivo experiments, cells were implanted on the CAM at embryonic day 7 (E7), ATRA treatment was between E11 and E13 and tumours were analysed at E14. Results Treatment of IMR32 and BE2C cells in vitro with 10 μM ATRA resulted in a change in cell morphology, a 65% decrease in cell proliferation, upregulation of STMN4 and ROBO2 and downregulation of KLF4. ATRA proved more effective than MLN8237 in these assays. In vivo, 100 μM ATRA repetitive treatment at E11, E12 and E13 promoted a change in expression of differentiation markers and reduced proliferation by 43% (p < 0.05). 40 μM ATRA treatment at E11 and E13 reduced proliferation by 37% (p < 0.05) and also changed cell morphology within the tumour. Conclusion Differentiation of neuroblastoma tumours formed on the chick CAM can be analysed by changes in cell morphology, proliferation and gene expression. The well-described effects of ATRA on neuroblastoma differentiation were recapitulated within 3 days in the chick embryo model, which therefore offers a rapid, cost effective model compliant with the 3Rs to select promising drugs for further preclinical analysis

'A Saxon who’s learnt a lot from the Americans':Clemens Meyer in a transnational literary context

In recent years, Clemens Meyer has emerged as the literary voice of societal underdogs. Initially celebrated as the ‘tattoo-man of German literature’ (Elmar Krekeler) whose ‘rough’ East German background seemed to have certified the authenticity of his subject, with his growing success, Meyer has managed to shake off the exclusive, and somewhat limiting, label of ‘East German writer’ with its often specifically provincial associations. The publication of his latest novel Im Stein (2013, Underground) has finally led to Meyer’s recognition as a more high-brow writer whose work has entered the transnational literary field. In his novel, Meyer self-consciously references world literary predecessors who have inspired him (for example Dos Passos and Hemingway) but adapts these literary models to develop a singular style that goes beyond mere intertextual allusions. My reading of Im Stein, a multi-voiced novel that revolves around organized prostitution in an unnamed East German city post-1989, thus ties in with recent debates focussing on the notion of ‘world literature’. Following Gayatri Chakravorty Spivak’s thoughts on ‘singularity’ in relation to world literature, I argue that it is precisely Meyer’s engagement with the specificity of his subject matter through writing ‘transnationally’ that allows the author to achieve ‘singularity’. This then paves the way for his work’s ‘universalizability’ and, consequently, for Meyer’s conscious adaptation of his work to world literature

Creative collaboration in citizen science and the evolution of ThinkCamps

This chapter discusses how to harness the potential of creative collaboration through ThinkCamp events – an ‘unconference’ style event with an open and creative environment designed to foster co-creation, co-design and collaborative thinking at key points in the citizen science research cycle. It draws on the authors’ experiences of running (and participating in) creative collaborative events and explores their potential to support inclusive, co-creational approaches to citizen science. Finally, it makes specific recommendations for project initiators, event organisers and policymakers

Mastication Dyspraxia: A Neurodevelopmental Disorder Reflecting Disruption of the Cerebellocerebral Network Involved in Planned Actions

This paper reports the longitudinal clinical, neurocognitive, and neuroradiological findings in an adolescent patient with nonprogressive motor and cognitive disturbances consistent with a diagnosis of developmental coordination disorder (DCD). In addition to prototypical DCD, the development of mastication was severely impaired, while no evidence of swallowing apraxia, dysphagia, sensorimotor disturbances, abnormal tone, or impaired general cognition was found. He suffered from bronchopulmonary dysplasia and was ventilated as a newborn for 1.5 months. At the age of 3 months, a ventriculoperitoneal shunt was surgically installed because of obstructive hydrocephalus secondary to perinatal intraventricular bleeding. At the age of 5 years, the patient’s attempts to masticate were characterized by rough, effortful, and laborious biting movements confined to the vertical plane. Solid food particles had a tendency to get struck in his mouth and there was constant spillage. As a substitute for mastication, he moved the unground food with his fingers in a lateral direction to the mandibular and maxillary vestibule to externally manipulate and squeeze the food between cheek and teeth with the palm of his hand. Once the food was sufficiently soft, the bolus was correctly transported by the tongue in posterior direction and normal deglutition took place. Repeat magnetic resonance imaging (MRI) during follow-up disclosed mild structural abnormalities as the sequelae of the perinatal intraventricular bleeding, but this could not explain impaired mastication behavior. Quantified Tc-99m-ethylcysteinate dimer single-photon emission computed tomography (Tc-99m-ECD SPECT), however, revealed decreased perfusion in the left cerebellar hemisphere, as well as in both inferior lateral frontal regions, both motor cortices, and the right anterior and lateral temporal areas. Anatomoclinical findings in this patient with DCD not only indicate that the functional integrity of the cerebellocerebral network is crucially important in the planning and execution of skilled actions, but also seem to show for the first time that mastication deficits may be of true apraxic origin. As a result, it is hypothesized that “mastication dyspraxia” may have to be considered as a distinct nosological entity within the group of the developmental dyspraxias following a disruption of the cerebellocerebral network involved in planned actions