Closed adjective classes and primary adjectives in African Languages

The existence of closed adjective classes (henceforth CAC) has long been recognized for African languages. Although I probably haven't found the earliest mention of this property , Welmers' 1973 statement in 'African Language Structures' is often quoted. Subsequent mentions of CAC are found in Dixon (1977 revised 1982, 1999, 2004), and although he seldom refers to African languages, he has been repeatedly cited since. Yet there has been no attempt to provide a general overview of the phenomenon, and the present paper aims at filling this gap

The role of lymphatics in renal inflammation

Progressive renal diseases are characterized by tubulointerstitial inflammatory cell recruitment, tubular atrophy and fibrosis. Various aspects of the recruitment of leukocytes have been extensively studied, but the exit routes (i.e. the lymphatic vessels and their biology) have only recently found attention. Similar to the recruitment of inflammatory cells, the exit is coordinated by an orchestrated interaction of chemotactic cytokines and adhesion molecules. During inflammatory injury, new routes are created by the de novo formation of lymphatic vessels, i.e. neolymphangiogenesis. These newly formed lymphatic vessels help to cope with the increase in interstitial fluid related to inflammation. Here, we review some aspects of lymphatic biology and the current knowledge about lymphatic vessels in renal inflammatio

Hyperglycemia and Hyperlipidemia Act Synergistically to Induce Renal Disease in LDL Receptor-Deficient BALB Mice

Diabetic nephropathy is the leading cause of end-stage renal disease in Western countries, but only a portion of diabetic patients develop diabetic nephropathy. Dyslipidemia represents an important aspect of the metabolic imbalance in diabetic patients. In this study, we addressed the impact of combined hyperlipidemia and hyperglycemia on renal pathology. Kidneys from wildtype (WT) or LDL receptor-deficient BALB/cBy mice (BALB. LDLR -/-) were examined at 22 weeks of age. Diabetes was induced by administration of streptozotocin and mice were randomly assigned to either standard chow or Western diet. Chow fed BALB. LDLR -/- mice did not demonstrate renal abnormalities, whereas BALB. LDLR -/- mice fed a Western diet showed occasional glomerular and tubulointerstitial foam cells. Diabetic WT mice had modestly increased glomerular cellularity and extracellular matrix. Hyperlipidemic and diabetic BALB. LDLR -/- mice exhibited an increase in glomerular cellularity and extracellular matrix, accumulation of glomerular and tubulointerstitial foam cells and mesangial lipid deposits. The tubular epithelium demonstrated pronounced lipid induced tubular degeneration with increased tubular epithelial cell turnover. Hyperlipidemia and hyperglycemia seem to act synergistically in inducing renal injury in the BALB. LDLR-/- mouse. This model of diabetic nephropathy is unique in its development of tubular lesions and may represent a good model for hyperlipidemia-exacerbated diabetic nephropathy. Copyright (C) 2004 S. Karger AG, Basel

Emergence and Persistence of Collective Cell Migration on Small Circular Micropatterns

The spontaneous formation of vortices is a hallmark of collective cellular activity. Here, we study the onset and persistence of coherent angular motion (CAMo) as a function of the number of cells $N$ confined in circular micropatterns. We find that the persistence of CAMo increases with $N$ but exhibits a pronounced discontinuity accompanied by a geometric rearrangement of cells to a configuration containing a central cell. Computer simulations based on a generalized Potts model reproduce the emergence of vortex states and show in agreement with experiment that their stability depends on the interplay of spatial arrangement and internal polarization of neighboring cells. Hence, the distinct migrational states in finite size ensembles reveal significant insight into the local interaction rules guiding collective migration.Comment: 5 pages, 4 figure

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice

Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine receptor-bearing leukocytes. Chemokines play important roles in leukocyte trafficking and blocking chemokines can effectively reduce renal leukocyte recruitment and subsequent renal damage. However, recent data indicate that blocking chemokine or chemokine receptor activity in renal disease may also exacerbate renal inflammation under certain conditions. An increasing amount of data indicates additional roles of chemokines in the regulation of innate and adaptive immune responses, which may adversively affect the outcome of interventional studies. This review summarizes available in vivo studies on the blockade of chemokines and chemokine receptors in kidney diseases, with a special focus on the therapeutic potential of anti-chemokine strategies, including potential side effects, in renal disease. Copyright (C) 2004 S. Karger AG, Basel

Synergistic Bcl-2 inhibition by ABT-737 and cyclosporine A

Survival of lymphocytes and melanocyte stem cells critically depends on B cell lymphoma 2 (Bcl-2). In T lymphocytes, a basal calcineurin activity maintains Bcl-2 expression in naïve cells, and the activation of the calcineurin pathway orchestrates the regulation of the intrinsic apoptosis pathway after antigen recognition. Therefore, calcineurin inhibitors might potentiate the pro-apoptotic effect of pharmacological Bcl-2 inhibitors on lymphatic cells. In vitro, a reduced Bcl-2 expression in lymphocytes exposed to calcineurin inhibitors increased their sensitivity to the small molecule Bcl-2 inhibitor ABT-737. This correlated with an augmented pro-apoptotic activity of ABT-737 on lymphocytes in combination with cyclosporine A in naïve mice in vivo. Interestingly, similar processes were observed in melanocytes. ABT-737 induced a fur depigmentation at the site of injection, and this effect was expanded to a generalized depigmentation in combination with cyclosporine A. Thus, inhibiting calcineurin increases the pro-apoptotic potency of ABT-737 in cells depending on Bcl-2 for survival. The increased efficacy of Bcl-2 inhibitors in combination with cyclosporine A might be relevant to exploit their anti-neoplastic and immuno-modulatory propertie

The treatment of a pregnant HIV positive patient with cryptococcal meningitis in Malawi. Case report and review of treatment options

This case reports cryptococcal meningitis in an HIV positive woman on antiretroviral therapy, presenting with left middle cerebral artery stroke at 30 weeks gestation. The patient had well-controlled HIV (CD4 count over 200 cells/mL). The immunosuppressive effects of the pregnancy likely contributed to the development of cryptococcal disease. The patient was successfully treated with two weeks of amphotericin B followed by fluconazole, delivered a healthy baby, but remained with a permanent severe neurological deficit

Setting a course to a greener future: Life-cycle Assessment of General Cargo Ships under 5,000 GT and the regulatory compliance with the FuelEU maritime regulation

To mitigate emissions and negative environmental impacts from maritime transportation, a transition to climate-friendly fuels and propulsion systems is necessary. The FuelEU maritime regulation aims to facilitate this transition, but currently excludes ships below 5,000 GT. Additionally, there's limited understanding of the environmental impact of general cargo ships, particularly smaller vessels below 5,000 GT. This study investigates the life-cycle performance of small general cargo ships with three different propulsion systems and assesses their potential compliance with the FuelEU maritime regulation. A well-to-wake attributional life-cycle assessment of one model general cargo ship (> 5,000 GT) with three different propulsion systems is conducted. The different propulsion systems are marine gas oil (Case 1), electro-methanol (Case 2) and battery-electric (Case 3). Four phases of the ship and its fuel are considered: (1) shipbuilding phase; (2) ship operation; (3) ship maintenance and replacements and the (4) fuel life-cycle. Case 3 is excluded from the results because it was considered technically infeasible. The compliance with the FuelEU maritime regulation was assessed by estimating the minimum share of eMeOH necessary to meet the required emission reduction targets. The LCA results show that Case 2 resulted in a better life-cycle performance for most impact categories compared to Case 1. The operational and fuel production phases had the most significant life-cycle impact. Sensitivity analysis highlighted the influence of the fuel production pathway, especially the carbon intensity of electricity for producing methanol in Case 2. The analysis of the FuelEU maritime regulation showed the minimum shares of eMeOH necessary to comply with the required emission intensities, starting from 2% in 2025 to 97% in 2050. In addition, concerns were raised about missed opportunities for emissions reduction and maritime innovation by excluding ships below 5,000 GT from this regulation. The study shows that eMeOH powered general cargo ships (< 5,000 GT) have potential to reduce the life-cycle impacts associated with maritime transport and suggests adjustments to the FuelEU maritime regulation to include general cargo ships (< 5,000 GT) for more effective emission reduction. Future research should explore broader implications of excluding ship below 5,000 GT from regulations and improve data availability for general cargo ships to provide a more comprehensive understanding of their environmental impact and policy effectiveness