Preliminary design studies of an advanced general aviation aircraft

The preliminary design results are presented of the advanced aircraft design project. The goal was to take a revolutionary look into the design of a general aviation aircraft. Phase 1 of the project included the preliminary design of two configurations, a pusher, and a tractor. Phase 2 included the selection of only one configuration for further study. The pusher configuration was selected on the basis of performance characteristics, cabin noise, natural laminar flow, and system layouts. The design was then iterated to achieve higher levels of performance

Medienwissenschaft und Kapitalismuskritik

Nachdem ›Kritik‹ während der vergangenen Jahrzehnte in vielen geistes- und kulturwissenschaftlichen Kreisen eher verschmäht wurde, erlebt sie gegenwärtig auch in der Medienwissenschaft wieder einen Aufschwung. Gerade das in Verruf geratene Projekt einer Gesellschaftskritik scheint seit der Finanzkrise von 2007 wieder an akademischer Attraktivität zu gewinnen. Dabei liegt die gedankliche Verbindung von Medienwissenschaft und Kapitalismuskritik nahe, schließt man damit doch an zwei dominante Selbstbeschreibungen der westlichen Gesellschaften an: die der Medien- oder Informationsgesellschaft einerseits und die einer kapitalistischen oder marktwirtschaftlichen Gesellschaft andererseits. Insofern scheint ein Dialog zwischen der Erforschung von Medien und der Erforschung des Kapitalismus geradezu zwingend. Das vorliegende Heft versammelt eine Reihe von Texten, die weniger konkrete Fallstudien zu einzelnen Medien und Medienpraktiken, sondern vornehmlich theoriebezogene Diskussionsbeiträge sind, welche das diskursive Feld der Medienwissenschaft und Medienforschung ausloten und auf die virulenten Fragen der Kapitalismuskritik hin befragen

A novel knee prosthesis model of implant-related osteo- myelitis in rats

Background and purpose: There have been numerous reports of animal models of osteomyelitis. Very few of these have been prosthesis models that imitate human conditions. We have developed a new rat model of implant-related osteomyelitis that mimics human osteomyelitis, to investigate the pathology of infection after orthop edic implant surgery. Methods: 2 wild-type strains of Staphylococcus aureus, MN8 and UAMS-1, and their corresponding mutants that are unable to produce poly-N-acetyl glucosamine (PNAG) (ica::tet) were injected into the medullary canals of the femur and tibia at 3 different doses: $10^2$, $10^3$, and > $10^4$ CFU/rat. We measured clinical signs, inflammatory markers, radiographic signs, histopathology, and bacteriology in the infected animals. Results: An inoculum of at least $10^4$ cfu of either wild-type bacterial strain resulted in histological, bacteriological, and radiographic signs of osteomyelitis with loosening of the prosthesis. An inoculum of $10^3$ CFU gave signs of osteomyelitis but the prosthesis remained in situ. Bacterial inocula of $10^2$ cfu gave no signs of osteolysis. Interpretation: We have established a new knee prosthesis model that is suitable for reliable induction of experimental implant-associated osteomyelitis with the prosthesis in situ, using a small inoculum of S. aureus. At a dose of $10^3$ CFU/rat, bacteria unable to produce PNAG (ica::tet) had only minor defects in their virulence

Effect of subinhibitory concentrations of four commonly used biocides on the conjugative transfer of Tn916 in Bacillus subtilis

OBJECTIVES: Large amounts of biocides are used to reduce and control bacterial growth in the healthcare sector, food production and agriculture. This work explores the effect of subinhibitory concentrations of four commonly used biocides (ethanol, hydrogen peroxide, chlorhexidine digluconate and sodium hypochlorite) on the conjugative transposition of the mobile genetic element Tn916. METHODS: Conjugation assays were carried out between Bacillus subtilis strains. The donor containing Tn916 was pre-exposed to subinhibitory concentrations of each biocide for a defined length of time, which was determined by an analysis of the transcriptional response of the promoter upstream of tet(M) using β-glucuronidase reporter assays. RESULTS: Ethanol significantly (P = 0.01) increased the transfer of Tn916 by 5-fold, whereas hydrogen peroxide, chlorhexidine digluconate and sodium hypochlorite did not significantly affect the transfer frequency. CONCLUSIONS: These results suggest that exposure to subinhibitory concentrations of ethanol may induce the transfer of Tn916-like elements and any resistance genes they contain

Advice on testing the null hypothesis that a sample is drawn from a Normal distribution.

The Normal distribution remains the most widely-used statistical model, so it is only natural that researchers will frequently be required to consider whether a sample of data appears to have been drawn from a Normal distribution. Commonly-used statistical packages offer a range of alternative formal statistical tests of the null hypothesis of Normality, with inference being drawn on the basis of a calculated p-value. Here we aim to review the statistical literature on the performance of these tests, and briefly survey current usage of them in recently-published papers, with a view to offering advice on good practice. We find that authors in animal behaviour seem to be using such testing most commonly in situations where it is inadvisable (or at best unnecessary) involving pre-testing to select parametric or not-parametric analyses; and making little use of it in model-fitting situations where it might be of value. Of the many alternative tests, we recommend the routine use of either the Shapiro-Wilk or Chen-Shapiro tests; these are almost always superior to commonly-used alternatives like the Kolmogorov-Smirnov test, often by a substantial margin. We describe how both our recommend tests can be implemented. In contrast to current practice as indicated by our survey, we recommend that the results of these tests are reported in more detail (providing both the calculated sample statistic and the associated p-value). Finally, emphasize that even the higher-performing tests of Normality have low power (generally below 0.5 and often much lower) when sample sizes are less than 50, as is often the case in our field. Keywords: Gaussian distribution, parametric statistics, Schapiro-Wilk test, statistics, statistical powe