A new species of <i>Ocyale</i> (Araneae, Lycosidae) from Madagascar, with first observations on the biology of a representative in the genus

A large white species of wolf spider, Ocyale ghost Jocque M. & Jocque R. sp. nov., is described from a white sandy beach of an inland freshwater lake in the northwest of Madagascar. The first photos of a living specimen of the genus Ocyale are provided together with some observations on the biology of the newly described species. An updated and illustrated key to the Afrotropical species of Ocyale is included here

Comparison between the Comfort and Hartwig sedation scales in pediatric patients undergoing mechanical lung ventilation

CONTEXT: A high number of hospitalized children do not receive adequate sedation due to inadequate evaluation and use of such agents. With the increase in knowledge of sedation and analgesia in recent years, concern has also risen, such that it is now not acceptable that incorrect evaluations of the state of children's pain and anxiety are made. OBJECTIVE: A comparison between the Comfort and Hartwig sedation scales in pediatric patients undergoing mechanical lung ventilation.DESIGN: Prospective cohort study. SETTING: A pediatric intensive care unit with three beds at an urban teaching hospital. PATIENTS: Thirty simultaneous and independent observations were conducted by specialists on 18 patients studied. DIAGNOSTIC TEST: Comfort and Hartwig scales were applied, after 3 minutes of observation. MAIN MEASUREMENTS: Agreement rate (kappa). RESULTS: On the Comfort scale, the averages for adequately sedated, insufficiently sedated, and over-sedated were 20.28 (SD 2.78), 27.5 (SD 0.70), and 15.1 (SD 1.10), respectively, whereas on the Hartwig scale, the averages for adequately sedated, insufficiently sedated, and over-sedated were 16.35 (SD 0.77), 20.85 (SD 1.57), and 13.0 (SD 0.89), respectively. The observed agreement rate was 63% (p = 0.006) and the expected agreement rate was 44% with a Kappa coefficient of 0.345238 (z = 2.49). CONCLUSIONS: In our study there was no statistically significant difference whether the more complex Comfort scale was applied (8 physiological and behavioral parameters) or the less complex Hartwig scale (5 behavioral parameters) was applied to assess the sedation of mechanically ventilated pediatric patients.CONTEXTO: É elevado o número de crianças hospitalizadas que não recebem uma sedação adequada, devido a avaliação e ao uso inadequado desses agentes. Nos últimos anos aumentou a preocupação e os conhecimentos a respeito da sedação e analgesia, de tal modo que é inaceitável hoje em dia termos uma criança sem correta avaliação de seu estado de dor e ansiedade. OBJETIVO: Comparar o uso de duas escalas de sedação (COMFORT e HARTWIG) em pacientes pediátricos em ventilação pulmonar mecânica. TIPO DE ESTUDO: Estudo prospectivo. LOCAL: Unidade de cuidados intensivos pediátricos de hospital terciário. PARTICIPANTES: Realizadas 30 observações, simultâneas e independentes, em 18 pacientes, por médicos especializados. TESTE DIAGNÓSTICO: Após observação de três minutos, aplicou-se critérios objetivos (escalas de COMFORT e HARTWIG) para avaliar a sedação. VARIÁVEL ESTUDADA: Taxa de concordância (Coeficiente Kappa) onde p < 0,01 foi considerado significante. RESULTADOS: Escala COMFORT (média e desvio padrão) para adequadamente sedado, inadequadamente sedado e muito sedado foi 20,28 ± 2,78, 27,5 ± 0,70 e 15,1 ± 1,10 respectivamente. Para a escala de HARTWIG: 16,35 ± 0,77, 20,85 ± 1,57 e 13,0 ± 0,89. Taxa de concordância observada 63% (p = 0,006), esperada de 44% com o coeficiente kappa = 0,345238 (z = 2,49). CONCLUSÕES: Em nosso estudo, não houve diferença significativa na aplicabilidade entre as escalas de COMFORT e HARTWIG em assegurar o nível de sedação em crianças submetidas a ventilação pulmonar mecânica.Universidade Federal de São Paulo (UNIFESP)Escola Paulista de MedicinaHospital do Servidor Público Municipal de São PauloUNIFESP, EPMSciEL

Asservissement d'un bras robotique d'assistance à l'aide d'un système de stéréo vision artificielle et d'un suiveur de regard

RÉSUMÉ L’utilisation récente de bras robotiques sériels dans le but d’assister des personnes ayant des problèmes de motricités sévères des membres supérieurs soulève une nouvelle problématique au niveau de l’interaction humain-machine (IHM). En effet, jusqu’à maintenant le « joystick » est utilisé pour contrôler un bras robotiques d’assistance (BRA). Pour les utilisateurs ayant des problèmes de motricité sévères des membres supérieurs, ce type de contrôle n’est pas une option adéquate. Ce mémoire présente une autre option afin de pallier cette problématique. La solution présentée est composée de deux composantes principales. La première est une caméra de stéréo vision utilisée afin d’informer le BRA des objets présents dans son espace de travail. Il est important qu’un BRA soit conscient de ce qui est présent dans son espace de travail puisqu’il doit être en mesure d’éviter les objets non voulus lorsqu’il parcourt un trajet afin d’atteindre l’objet d’intérêt pour l'utilisateur. La deuxième composante est l’IHM qui est dans ce travail représentée par un suiveur de regard à bas coût. Effectivement, le suiveur de regard a été choisi puisque, généralement, les yeux d’un patient ayant des problèmes sévères de motricités au niveau des membres supérieurs restent toujours fonctionnels. Le suiveur de regard est généralement utilisé avec un écran pour des applications en 2D ce qui n’est pas intuitif pour l’utilisateur puisque celui-ci doit constamment regarder une reproduction 2D de la scène sur un écran. En d’autres mots, il faut rendre le suiveur de regard viable dans un environnement 3D sans l’utilisation d’un écran, ce qui a été fait dans ce mémoire. Un système de stéréo vision, un suiveur de regard ainsi qu’un BRA sont les composantes principales du système présenté qui se nomme PoGARA qui est une abréviation pour Point of Gaze Assistive Robotic Arm. En utilisant PoGARA, l’utilisateur a été capable d’atteindre et de prendre un objet pour 80% des essais avec un temps moyen de 13.7 secondes sans obstacles, 15.3 secondes avec un obstacle et 16.3 secondes avec deux obstacles.----------ABSTRACT The recent increased interest in the use of serial robots to assist individuals with severe upper limb disability brought-up an important issue which is the design of the right human computer interaction (HCI). Indeed, so far, the control of assistive robotic arms (ARA) is often done using a joystick. For the users who have a severe upper limb disability, this type of control is not a suitable option. In this master’s thesis, a novel solution is presented to overcome this issue. The developed solution is composed of two main components. The first one is a stereo vision system which is used to inform the ARA of the content of its workspace. It is important for the ARA to be aware of what is present in its workspace since it needs to avoid the unwanted objects while it is on its way to grasp the object of interest. The second component is the actual HCI, where an eye tracker is used. Indeed, the eye tracker was chosen since the eyes, often, remain functional even for patients with severe upper limb disability. However, usually, low-cost, commercially available eye trackers are mainly designed for 2D applications with a screen which is not intuitive for the user since he needs to constantly watch a reproduction of the scene on a 2D screen instead of the 3D scene itself. In other words, the eye tracker needs to be made viable for usage in a 3D environment without the use of a screen. This was achieved in this master thesis work. A stereo vision system, an eye tracker as well as an ARA are the main components of the developed system named PoGARA which is short for Point of Gaze Assistive Robotic Arm. Using PoGARA, during the tests, the user was able to reach and grasp an object for 80% of the trials with an average time of 13.7 seconds without obstacles, 15.3 seconds with one obstacles and 16.3 seconds with two obstacles

North: Volume Two

North Volume Two reflects our belief in photography as a relevant tool for exploring our ever-changing world. Whether in Preston, Liverpool, Berlin or Guangzhou the image-makers create a conversation with contemporary life as they endeavour to make their surroundings legible. In this second edition we continue North in the streets and spaces of the city. From contested sites of demolition, to new imaginaries formulated in the studio and in domestic, digital and social space, the volume is testament to how the urban endures as one of photography’s perennial objects of study. Like the first edition, We aim to highlight our commitment to everyday life as a meaningful arena for research and cultural production

Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper

The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial growth and survival. This presents opportunities for the host to either harness their antimicrobial properties or limit their availability as defence strategies. Recent studies have shed some light on mechanisms by which copper and zinc regulation contribute to host defence, but there remain many unanswered questions at the cellular and molecular levels. Here we review the roles of these two metal ions in providing protection against infectious diseases in vivo, and in regulating innate immune responses. In particular, we focus on studies implicating zinc and copper in macrophage antimicrobial pathways, as well as the specific host genes encoding zinc transporters (SLC30A, SLC39A family members) and CTRs (copper transporters, ATP7 family members) that may contribute to pathogen control by these cells

Policy implementation challenges and barriers to access sexual and reproductive health services faced by people with disabilities: An intersectional analysis of policy actors’ perspectives in post-conflict Northern Uganda

Emerging from a 20-year armed conflict, Uganda adopted several laws and policies to protect the rights of people with disabilities, including their sexual and reproductive health (SRH) rights. However, the SRH rights of people with disabilities continue to be infringed in Uganda. We explored policy actors’ perceptions of existing prodisability legislation and policy implementation, their perceptions of potential barriers experienced by people with disabilities in accessing and using SRH services in post-conflict Northern Uganda, and their recommendations on how to redress these inequities.Through an intersectionality-informed approach, we conducted and thematically analysed 13 in-depth semi-structured interviews with macro level policy actors (national policy-makers and international and national organisations); seven focus groups (FGs) at meso level with 68 health service providers and representatives of disabled people’s organisations (DPOs); and a two-day participatory workshop on disability-sensitive health service provision for 34 healthcare providers

Disability and sexual and reproductive health service utilisation in Uganda: an intersectional analysis of demographic and health surveys between 2006 and 2016

Background: The United Nations through universal health coverage, including sexual and reproductive health (SRH), pledges to include all people, leaving no one behind. However, people with disabilities continue to experience multiple barriers in accessing SRH services. Studies analysing the impacts of disability in conjunction with other social identities and health determinants reveal a complex pattern in SRH service use. Framed within a larger mixed methods study conducted in Uganda, we examined how disability, among other key social determinants of health (SDH), was associated with the use of SRH services. Methods: We analysed data from repeated cross-sectional national surveys, the Uganda Demographic and Health Surveys (DHS) of 2006, 2011, and 2016. The three outcomes of interest were antenatal care visits, HIV testing, and modern contraception use. Our main exposure of interest was the type of disability, classified according to six functional dimensions: seeing, hearing, walking/climbing steps, remembering/concentrating, communicating, and selfcare. We performed descriptive and multivariable logistic regression analyses, which controlled for covariates such as survey year, sex, age, place of residence, education, and wealth index. Interaction terms between disability and other factors such as sex, education, and wealth index were explored. Regression analyses were informed by an intersectionality framework to highlight social and health disparities within groups. Results: From 2006 to 2016, 15.5-18.5% of study participants lived with some form of disability. Over the same period, the overall prevalence of at least four antenatal care visits increased from 48.3 to 61.0%, while overall HIV testing prevalence rose from 30.8 to 92.4% and the overall prevalence of modern contraception use increased from 18.6 to 34.2%. The DHS year, highest education level attained, and wealth index were the most consistent determinants of SRH service utilisation. People with different types of disabilities did not have the same SRH use patterns. Interactions between disability type and wealth index were associated with neither HIV testing nor the use of modern contraception. Women who were wealthy with hearing difficulty (Odds Ratio (OR) = 0.15, 95%CI 0.03 – 0.87) or with communication difficulty (OR = 0.17, 95%CI 0.03 – 0.82) had lower odds of having had optimal antenatal care visits compared to women without disabilities who were poorer