388 research outputs found

    Dr. Seitchik’s AI Research and Writing Companion: A Student\u27s Handbook for Leveraging Technology

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    This guide is intended to be utilized by students to help them use AI to assist in research and to scaffold their writing. Instructors can use it, if they allow AI to be used in their classes, to assist students in their research and writing endeavors. Some screenshots have been redacted for copyright reasons. A paper using this guide is under review and a citation will be provided when available. The guide can assist anyone when writing, especially research papers, but it is geared toward a student population for use in or outside of the classroom

    Spectroscopic Study of 75^{75}As and 139^{139}La NMR on Layered Structure Ferromagnet LaCoAsO

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    75^{75}As and 139^{139}La field-swept NMR spectra were obtained for the novel weakly itinerant ferromagnet LaCoAsO with 2D layered structure above the Curie temperature of 55 K. By analyzing NMR spectra, temperature dependences of Knight shift KK and nuclear quadrupole resonance frequency νQ\nu_Q were obtained successfully for each nucleus. We confirmed from the so-called KK-χ\chi plots that the macroscopic magnetization of our {LaCoAsO} powder sample is intrinsic and does not contain the contribution from impurity phases. We estimated hyperfine coupling constants from the slope of KK-χ\chi plots and compared to that of iron-arsenide superconductor.Comment: 5 pages, 5 figures, published on J. Phys. Soc. Jpn. at Vol.79, pp.054703 (2010)

    From One Job to the Next: Worker Adjustment in a Changing Labor Market

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    The authors discuss how the structure of job opportunities has changed over the last two decades; specifically the transfer of jobs from manufacturing to service industries. They then link these changes to issues of worker displacement policy and worker mobility.https://research.upjohn.org/up_press/1105/thumbnail.jp

    Worker Adjustment in Perspective

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    The authors discuss how the structure of job opportunities has changed over the last two decades; specifically the transfer of jobs from manufacturing to service industries. They then link these changes to issues of worker displacement policy and worker mobility.https://research.upjohn.org/up_press/1105/thumbnail.jp

    Enhancing Team Learning Experiences in the Classroom

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    There are many different and effective ways to introduce teams and team learning into the management classroom. This paper discusses different ways we incorporated group and team learning in the classroom using a variety of activities. From our initial student survey, we developed a measure of teamwork and independent learning. Our findings indicate that when students perceive a fair work distribution in their teams, they are also more team oriented than students who perceive an unfair work distribution. Suggestions for enhancements to team learning, and future ideas for research are discussed

    Site-selective protein-modification chemistry for basic biology and drug development.

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    Nature has produced intricate machinery to covalently diversify the structure of proteins after their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a large set of reactions that enable post-expression modification of proteins at pre-determined sites. These reactions are now used to selectively install particular modifications on proteins for many biological and therapeutic applications. For example, they provide an opportunity to install post-translational modifications on proteins to determine their exact biological roles. Labelling of proteins in live cells with fluorescent dyes allows protein uptake and intracellular trafficking to be tracked and also enables physiological parameters to be measured optically. Through the conjugation of potent cytotoxicants to antibodies, novel anti-cancer drugs with improved efficacy and reduced side effects may be obtained. In this Perspective, we highlight the most exciting current and future applications of chemical site-selective protein modification and consider which hurdles still need to be overcome for more widespread use.We thank FCT Portugal (FCT Investigator to G.J.L.B.), the EU (Marie-Curie CIG to G.J.L.B. and Marie-Curie IEF to O.B.) and the EPSRC for funding. G.J.L.B. is a Royal Society University Research Fellow.This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/nchem.239

    Bio-orthogonal Fluorescent Labelling of Biopolymers through Inverse-Electron-Demand Diels–Alder Reactions

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    Bio-ort hogona llabellin gschemes based on inverse-elec tron- deman dDiels–Ald er (IEDDA) cycloa ddition have attracted much attention in chem ical biology recently .The appeal ing features of this reactio n, such as the fast reactio nkinetics, fully bio-ort hogonal nature and high selectiv ity,have helped chem i- cal biologists gain deeper understandi ng of biochemic al pro- cesses at the molecular level.Listing the compo nents and dis- cussing the possib ilities andlimitations of thesereagent s, we provid earecent snapshot of the field of IEDDA -based biomo- lecular manipulatio nwith special focus on fluores cent modula- tion approaches throug hthe use of bio-orthogon alized build- ing blocks. At the end, we discuss challenges that need to be addres sed for further develop ments in order to overcome recent limita tions and to enabl eresearchers to answer biomo - lecular quest ions in more detail
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