Predictive Maintenance – Analysis of Seasonal Dependence of Vehicle Engine Faults

This paper presents methods and results for the analysis of interrelationships between the occurrence of specific engine faults according to seasons. The issue of maintenance is substantial for the automotive industry and improvements are requested due to the enhancement of profitability. Findings of this paper are based on logged-vehicle data from 760.976 vehicles provided by the company Geotab. Utilization of such data gains importance for the automotive service sector with special regard of increasing importance of predictive maintenance. The visualization of the data of three different engine faults was realized with the free graphic and statistics program “Tableau Desktop 2018.1” as well as “IBM SPSS Statistics Subscription Trial for Mac OS”. The result is that the tested interrelations are significant, leading to the conclusion that the engine faults of “vehicle battery has low voltage”, “low priority warning light on” and “general warning light on” are dependent of seasons. This finding can be used to help car manufacturers and car service providers to reduce maintenance costs. Keywords: automotive, big data, predictive maintenance, seasonal engine faults, vehicle error code

Local stress anomaly in the Bavarian Molasse Basin

Background: The characterization of fault zones in the Bavarian Molasse Basin plays a major role for further geothermal reservoir development. Hence, their identification, geological origin, and hydraulic characterization are discussed extensively. Methods: Stress indicators and fractures are interpreted from image and caliper logs of three highly deviated wells at the Sauerlach site. We transform the identified stress field into the borehole coordinate system and compare the observed orientation to the modeled stress field which assumes a homogeneous borehole surrounding. Results: High breakout occurrence, cross-cutting fractures, and a fracture orientation from N-S to NNE-SSW are observed in Sauerlach Th1. In Sauerlach Th2 and Th3, fractures strike primarily ENE-WSW and N-S to NNE-SSW. Drilling-enhanced natural fractures and drilling-induced tensile fractures are observed in all three wells and indicate the orientation of tensile stress at the borehole wall. In Sauerlach Th2 and Th3, stress transformation indicates a S$_{H}$-dir. ~ N 10°E in a strike-slip stress regime. The modeled stress orientations match the observed orientations within the well Sauerlach Th1 if either S$_{H}$-dir. is N 320°E in a strike-slip regime or S$_{H}$-dir. is N 10°E in a normal faulting regime. Conclusion: This approach improves the detection of the local stress field especially for non-vertical wells, which has, in combination with the facture pattern, a major impact on the hydraulic system of the geothermal reservoir

Stress state at faults: the influence of rock stiffness contrast, stress orientation, and ratio

The contemporary crustal stress state is primarily driven by gravitational volume forces and plate tectonics. However, there are various smaller-scale sources such as geological structures and stiffness contrast that perturb stresses and deviate them from the regional pattern. For example, borehole stress analysis in numerous cases has revealed abrupt rotations of horizontal stress orientation of up to 90° when faults are crossed. Herein, we investigate the rotation of principal stress axes at a fault by means of a 2D generic numerical model. We focus on the near field of the fault and the damage zone with a fault parameterized as a rock stiffness contrast. A substantial influence of the far-field stress field in terms of the differential stress and in terms of the stress ratio R$_S$ = S$_1$/S_3 is shown. Furthermore, the contrast in material properties is the basis for any stress rotation, and in particular the stiffness is demonstrated to have a significant influence. Eventually, the impact of the angle between the fault strike and the orientation of SHmax is demonstrated. Our results show that the stress rotation is negatively correlated with the ratio of principal far-field stresses. A small angle between the far-field stress orientation and the fault facilitates stress rotation. A high contrast in rock stiffness further increases the stress rotation angle. Faults striking perpendicular to the maximum principal stress orientation experience no rotation at all. However, faults oriented parallel to the maximum principal stress orientation experience either no rotation or a 90° rotation, dependent on the ratio of principal stresses and the rock stiffness contrast. A comparison with observations from various boreholes worldwide shows that in general the findings are in agreement, even though the dip angle proves to have an influence on the stress rotation, in particular for shallow-dipping faults

Phase I trial of ATM inhibitor M3541 in combination with palliative radiotherapy in patients with solid tumors

BACKGROUND: Ataxia telangiectasia mutated (ATM) kinase orchestrates DNA double strand break (DSB) repair; ATM inhibitors may therefore enhance the therapeutic effect of DSB-inducing treatments such as radiotherapy (RT). M3541 is an orally administered selective inhibitor of ATM. METHODS: This phase I dose-escalation study evaluated the maximum-tolerated dose (MTD), recommended phase II dose(s) (RP2D), safety, pharmacokinetics (PK) and antitumor activity of M3541 in combination with fractionated palliative RT in patients with solid tumors. Fifteen patients received palliative RT (30 Gy in 10 fractions) and escalating doses of M3541 (50-300 mg administered on RT fraction days) guided by a Bayesian 2-parameter logistic regression model with overdose control. RESULTS: Doses of M3541 up to 300 mg/fraction day were well tolerated. One patient (200 mg group) experienced two dose-limiting toxicities (urinary tract infection, febrile neutropenia) that resolved with antibiotics. All patients reported ≥ 1 treatment-emergent adverse event (TEAE) but none led to treatment discontinuation. No grade ≥ 4 TEAEs were reported and there was no indication of a dose effect for any TEAE. Three patients (20.0%; 95% confidence interval 4.3-48.1) had confirmed complete or partial response. M3541 total plasma levels did not increase with dose following single or repeated dosing. No relationship was observed between dose and changes in the ratio of phosphorylated to total ATM or in immune cell counts. CONCLUSIONS: The MTD and RP2D could not be established as the study closed early due to the absence of a dose-response relationship and non-optimal PK profile. No further clinical development of M3541 was pursued. (Trial registration number ClinicalTrials.gov NCT03225105. Registration date July 21, 2017)

Minute rebond: a simple method for making lab-scale rebonded foam and its application as a novel soilless growing media

Polyurethane foams (PUFs) utilised in the comfort industry generate substantial trim waste volumes requiring end-of-life management. Rebonding, one form of mechanical recycling, is a technique involving the mechanical breakdown and subsequent adhesion of PUF using polyurethane prepolymers yielding a recycled material. However, the limited investigation into the properties of rebond PUF constrains its potential for novel alternative uses, such as soilless plant-growing media. A laboratory-scale rebond production method has been developed, and a series of rebond PUFs produced to evaluate the influence of crumb size, density, prepolymer chemistry, and prepolymer loading on the properties of the rebond PUFs and their suitability as growing media. The results indicated that higher quality rebonds were obtained with larger crumb sizes (mixed or >7 mm), moderate amounts of prepolymer (4.5 to 7.5% by mass), and higher densities. Increasing density directly influenced plant growth-related properties, including reducing airflow, increasing water uptake through wicking, and increasing water retention through drainage alongside larger crumb sizes [>7 mm]. To demonstrate the method’s utility for rapid screening, a plant growth trial was conducted using density as the key variable. Eruca sativa plants grown in low-density rebonds exhibited comparable growth (leaf length, leaf width, and shoot fresh weight) to mineral wool, whereas medium- and high-density rebonds showed reduced growth. This study validates a lab-scale technique that enables the rapid optimisation of rebond PUFs for novel applications like soilless growing media

Stress state at faults: the influence of rock stiffness contrast, stress orientation, and ratio

The contemporary crustal stress state is primarily driven by gravitational volume forces and plate tectonics. However, there are various smaller-scale sources such as geological structures and stiffness contrast that perturb stresses and deviate them from the regional pattern. For example, borehole stress analysis in numerous cases has revealed abrupt rotations of horizontal stress orientation of up to 90° when faults are crossed. Herein, we investigate the rotation of principal stress axes at a fault by means of a 2D generic numerical model. We focus on the near field of the fault and the damage zone with a fault parameterized as a rock stiffness contrast. A substantial influence of the far-field stress field in terms of the differential stress and in terms of the stress ratio RS=S₁/S_3 is shown. Furthermore, the contrast in material properties is the basis for any stress rotation, and in particular the stiffness is demonstrated to have a significant influence. Eventually, the impact of the angle between the fault strike and the orientation of SHmax is demonstrated. Our results show that the stress rotation is negatively correlated with the ratio of principal far-field stresses. A small angle between the far-field stress orientation and the fault facilitates stress rotation. A high contrast in rock stiffness further increases the stress rotation angle. Faults striking perpendicular to the maximum principal stress orientation experience no rotation at all. However, faults oriented parallel to the maximum principal stress orientation experience either no rotation or a 90° rotation, dependent on the ratio of principal stresses and the rock stiffness contrast. A comparison with observations from various boreholes worldwide shows that in general the findings are in agreement, even though the dip angle proves to have an influence on the stress rotation, in particular for shallow-dipping faults

Uptake/Efflux Transport of Tramadol Enantiomers and O-Desmethyl-Tramadol: Focus on P-Glycoprotein

Abstract: The analgesic effect of tramadol (TMD) results from the monoaminergic effect of its two enantiomers, (+)-TMD and ())-TMD as well as its opioid metabolite (+)-O-desmethyl-tramadol (M1). P-glycoprotein (P-gp) might be of importance in the analgesic and tolerability profile variability of TMD. Our study investigated the involvement of P-gp in the transepithelial transport of (+)-TMD, ())-TMD and M1, using a Caco-2 cell monolayer model. The bidirectional transport of racemic TMD and M1 (1–100 lM) across the monolayers was investigated at two pH conditions (pH 6.8/7.4 and 7.4/7.4) in the presence and absence of P-gp inhibitor cyclosporine A (10 lM) and assessed with the more potent and specific P-gp inhibitor GF120918 (4 lM). Analytical quantification was performed by liquid chromatography coupled to the fluorescence detector. A net secretion of (+)-TMD, ())-TMD and M1 was observed when a pH gradient was applied (TR: Papp(B) A)/Papp(A) B): 1.8–2.7; P < 0.05). However, the bidirectional transport of all compounds was equal in the non-gradient system. In the presence of P-gp inhibitors, a slight but significant increase of secretory flux was observed (up to 26%; P < 0.05) at both pH conditions. In conclusion, (+)-TMD, ())-TMD and M1 are not P-gp substrates. However, proton-based efflux pumps may be involved in limiting the gastrointestinal absorption of TMD enantiomers as well as enhancing TMD enantiomers and M1 renal excretion. A possible involvement of uptake carriers in the transepithelial transport of TMD enantiomers and M1 is suggested. Tramadol hydrochloride (TMD) is a centrally acting analgesi