Emotional regulation and aggression in children: The regulatory role of Turkish mothers' emotion socialization reactions

Objective The main aim of this research is to determine whether positive or negative maternal reactions in the field of emotional socialization play an intermediary role in the relationship between a child's emotional regulation skills and aggressive behavior. Background Previous findings show the effects of children's emotion regulation skills and parents' emotional socialization responses on aggressive behavior. However, researchers have not reported how children's emotion regulation skills influence maternal emotional socialization responses or investigated the mediating role of maternal emotional socialization responses on emotion regulation and aggressive behavior. Method The study was conducted with 285 mothers of 60- to 72-month-old children attending preschool. Research data were collected using the Children Aggression Scale-Parent Version, Dealing With Negative Emotions of Children, Emotional Regulation Checklist, Attachment Insecurity Screening Inventory, Parental Attitude Scale, and Child-Parent Relationship Scale. Results Positive and negative responses of mothers play a mediating role in the relationship between children's aggression and emotional regulation. Mothers' positive responses were effective in reducing the aggression level of children with a low level of emotional regulation. In addition, even if children's emotional regulation skills are low, positive responses are effective in reducing mothers' negative reactions and thus children's aggression levels. Implications Given the importance of promoting positive development in children, this study may have important implications for intervention and prevention programs. In particular, family-based interventions that encourage mothers to use emotional socialization applications and education/techniques that encourage parents' emotional regulation strategies are recommended

Effects of Aminoguanidine on Lipid and Protein Oxidation in Diabetic Rat Kidneys

Nonenzymatic glycation of tissue and plasma proteins may stimulate the production of oxidant and carbonyl stress in diabetes. The aim of this study was to evaluate the effects of aminoguanidine (AG) on lipid peroxidation, protein oxidation and nitric oxide (NO) release in diabetic rat kidneys. After induction of diabetes with streptozotocin, female Wistar rats were divided into 2 groups. Group DAG (n=9) rats were given AG hydrogen carbonate (1 g/L) in drinking water and group D (n=8) was diabetic control rats given only tap water. Group H (n=8) was followed as healthy controls. At the end of an 8 week period, NO release, lipid and protein oxidation were determined in kidney tissues. NO release was significantly lower in diabetic rats compared with healthy controls (p<0.05). Lipid peroxidation was significantly high in group D (3.9 ± 0.3 nmol MDA/g tissue) compared with the group DAG (2.6 ± 0.1 nmol MDA/g tissue, p<0.01) and group H (2.4 ± 0.2 nmol MDA/g tissue). Protein oxidation was significantly higher in diabetics than healthy controls (563.8 ± 23.9, 655.8 ± 7.2 , 431.5 ± 8.8 mmol carbonyl / g tissue for group DAG, D and H, respectively, p< 0.05). A positive correlation between albuminuria and thiobarbituric acid reactive substance (TBARS) levels (r= 0.54,p<0.005) and carbonyl content (r=0.70, p<0.0005) in kidney homogenate were observed

Effects of Aminoguanidine on Glomerular Basement Membrane Thickness and Anionic Charge in a Diabetic Rat Model

We investigated the effect of aminoguanidine (AG) administration on GBM thickness, glomerular heparan sulfate (HS) content, and urinary albumin and HS excretion in diabetic rats. After induction of diabetes, female Wistar rats were divided into 2 groups: Group AGDM (n=11) received 1g/L aminoguanidine bicarbonate in drinking water, group DC (n=12) was given only tap water. Control rats received AG (group AGH, n=8) or tap water (group HC, n=8). At the end of a period of 8 weeks, urinary albumin and glycosaminoglycan (GAG) excretion was detected. GBM heparan sulfate distribution and count was determined under the electron microscope. The AGDM group had lower urinary albumin and GAG excretion than diabetic controls. GBM thickness was increased in diabetic rats compared to groups of AGDM and HC. In AGDM group alcian blue stained particle distribution and count in the GBM was similar to healthy controls. In conclusion AG prevents the decrease of anionic charged molecules in the GBM and GBM thickening. This can be one of the mechanisms by which AG decreases albuminuria in diabetic rats

Effects of ketoconazole in hirsute women

Abstract. To determine the efficacy of ketoconazole in the treatment of hirsutism, clinical and hormonal effects of this agent were evaluated with a randomized, placebocontrolled, double-blind cross-over study design. Nine hirsute women were given ketoconazole (600 mg/day) or placebo for 6 months and then crossed over. The severity of hirsutism was assessed according to the scale of Ferriman &amp; Gallwey. Baseline serum testosterone, dehydroepiandrosterone sulphate, progesterone, estradiol, basal and stimulated cortisol and 17-alpha hydroxyprogesterone were measured. Blood was also drawn for FSH and LH levels at 0, 30, 60, and 90 min of a GnRH stimulation test. The same parameters were determined following administration of placebo or ketoconazole for 6 months. The pretreatment (28.3±0.9) and post-placebo (27.7±1.4) Ferriman-Gallwey scores were significantly higher than the post-ketoconazole score (16.6±1.3, p≤0.01). Basal and stimulated cortisol levels were not blunted after ketoconazole, but basal and stimulated 17-hydroxyprogesterone levels were significantly higher, indicating sufficient enzymatic inhibition. Serum dehydroepiandrosterone sulphate and testosterone levels were significantly lowered following ketoconazole (p≤0.05). Although E2 levels did not change significantly at any time, E2:testosterone ratios were significantly higher after ketoconazole (p≤0.01), and the LH:FSH area ratio was also significantly greater than 3 after ketoconazole. It is concluded that ketoconazole significantly alleviates hirsutism by inhibiting steroid synthesis.</jats:p

The Moderating Effects Of A Child&apos;s Self-Regulation Skills İn The Relationship Between A Child’s Temperament And The Behaviour Of The Parents

This study investigated the moderating effect of the self-regulation skills of children on their temperamental traits and on the mother’s parenting behaviour. The random sampling method was used to obtain the study’s participants: 253 children attending pre-school and their mothers. Research data was collected using the ‘The child behaviour list short form’ ‘Alabama Parenting Questionnaire’ ‘Self-regulation assessment’. The results reveal that diligent control and self-regulation skills directly influence positive parental behaviour and that the relationship between diligent control and positive behaviour is differentiated depending on the self-regulating capacity of a child. Second, this study determined that negative affect temperament and self-regulation skills directly influence negative parental behaviour and that the relationship between negative affect and negative parental behaviour differs in accordance with a child’s self-regulation skills.Early Child Development and Car

Intrasellar hydatid cyst

✓ The authors report a case of hypopituitarism due to a cystic lesion in the sella turcica which was revealed by neuroradiological investigations. A hydatid cyst was found and removed by the transsphenoidal route. The transsphenoidal approach avoided intracranial spillage of fertile daughter cyst and scolices.</jats:p