Interregional synchrony of visuomotor tracking: perturbation effects and individual differences

The present study evaluated the neural and behavioural correlates associated with a visuomotor tracking task during which a sensory perturbation was introduced that created a directional bias between moving hand and cursor position. The results revealed that trajectory error increased as a result of the perturbation in conjunction with a dynamic neural reorganization of cluster patterns that reflected distinct processing. In particular, a negatively activated cluster, characterizing the degraded information processing due to the perturbation, involved both hemispheres as well as midline area. Conversely, a positively activated cluster, indicative of compensatory processing was strongly confined to the left (dominant) hemisphere. In addition, a brain-behavioural association of good vs. poor performing participants enabled to localize a neural circuit within the left hemisphere and midline area that linked with successful performance. Overall, these data reinforce the functional significance of interregional synchrony in defining response output and behavioural success

Control of manipulative forces during unimanual and bimanual tasks in patients with Huntington's disease

The aim of the study was to investigate gripload force regulation in Huntington's disease (HD) patients as compared to control subjects during the performance of a manipulative task that required rhythmical unimanual or bimanual isodirectional/non-isodirectional actions in the sagittal plane. Results showed that the profile of grip-load ratio force was characterized by maxima and minima that were attained at upward and downward hand positions, respectively. Minimum force ratio was higher in patients than in controls, which points to an elevated baseline that may be related to the inherent bradykinesia observed in HD. Maximum force ratio was also increased in patients, but this effect depended on the performance condition, with largest amplifications occurring during non-isodirectional movements. The latter rescaling may be associated with the complexity of the coordination mode and its asymmetrical load characteristics. In addition, the temporal delay between the grip and load force peaks was augmented in patients versus controls, indicating a disturbed coupled activation of both forces. Furthermore, the interval was largest during nonisodirectional movements followed by isodirectional and unimanual movements, which denotes that the grip-load force coupling deteriorated as a function of coordinative complexity. Together, these data indicate a deficit in the grip-load force constraint due to HD and illustrate the degrading effect of striatal dysfunction on (bi)manual manipulative functio

Motor timing and covariation with time perception: investigating the role of handedness

Time is a fundamental dimension of our behavior and enables us to guide our actions and to experience time such as predicting collisions or listening to music. In this study, we investigate the regulation and covariation of motor timing and time perception functions in left- and right-handers who are characterized by distinct brain processing mechanisms for cognitive-motor control. To this purpose, we use a combination of tasks that assess the timed responses during movements and the perception of time intervals. The results showed a positive association across left- and right-handers between movement-driven timing and perceived interval duration when adopting a preferred tempo, suggesting cross-domain coupling between both abilities when an intrinsic timescale is present. Handedness guided motor timing during externally-driven conditions that required cognitive intervention, which specifies the relevance of action expertise for the performance of timed-based motor activities. Overall, our results reveal that individual variation across domain-general and domain-specific levels of organization plays a steering role in how one predicts, perceives and experiences time, which accordingly impacts on cognition and behavior

Changes in balance coordination and transfer to an unlearned balance task after slackline training: a self-organizing map analysis

How humans maintain balance and change postural control due to age, injury, immobility or training is one of the basic questions in motor control. One of the problems in understanding postural control is the large set of degrees of freedom in the human motor system. Therefore, a self-organizing map (SOM), a type of artificial neural network, was used in the present study to extract and visualize information about high-dimensional balance strategies before and after a 6-week slackline training intervention. Thirteen subjects performed a flamingo and slackline balance task before and after the training while full body kinematics were measured. Range of motion, velocity and frequency of the center of mass and joint angles from the pelvis, trunk and lower leg (45 variables) were calculated and subsequently analyzed with an SOM. Subjects increased their standing time significantly on the flamingo (average +2.93 s, Cohen’s d = 1.04) and slackline (+9.55 s, d = 3.28) tasks, but the effect size was more than three times larger in the slackline. The SOM analysis, followed by a k- means clustering and marginal homogeneity test, showed that the balance coordination pattern was significantly different between pre- and post-test for the slackline task only (χ2 = 82.247; p 0.001). The shift in balance coordination on the slackline could be characterized by an increase in range of motion and a decrease in velocity and frequency in nearly all degrees of freedom simultaneously. The observation of low transfer of coordination strategies to the flamingo task adds further evidence for the task-specificity principle of balance training, meaning that slackline training alone will be insufficient to increase postural control in other challenging situations

Multiscale Topological Properties Of Functional Brain Networks During Motor Imagery After Stroke

In recent years, network analyses have been used to evaluate brain reorganization following stroke. However, many studies have often focused on single topological scales, leading to an incomplete model of how focal brain lesions affect multiple network properties simultaneously and how changes on smaller scales influence those on larger scales. In an EEG-based experiment on the performance of hand motor imagery (MI) in 20 patients with unilateral stroke, we observed that the anatomic lesion affects the functional brain network on multiple levels. In the beta (13-30 Hz) frequency band, the MI of the affected hand (Ahand) elicited a significantly lower smallworldness and local efficiency (Eloc) versus the unaffected hand (Uhand). Notably, the abnormal reduction in Eloc significantly depended on the increase in interhemispheric connectivity, which was in turn determined primarily by the rise in regional connectivity in the parieto-occipital sites of the affected hemisphere. Further, in contrast to the Uhand MI, in which significantly high connectivity was observed for the contralateral sensorimotor regions of the unaffected hemisphere, the regions that increased in connection during the Ahand MI lay in the frontal and parietal regions of the contralaterally affected hemisphere. Finally, the overall sensorimotor function of our patients, as measured by Fugl-Meyer Assessment (FMA) index, was significantly predicted by the connectivity of their affected hemisphere. These results increase our understanding of stroke-induced alterations in functional brain networks.Comment: Neuroimage, accepted manuscript (unedited version) available online 19-June-201

Bilateral Assessment of Functional Tasks for Robot-assisted Therapy Applications

This article presents a novel evaluation system along with methods to evaluate bilateral coordination of arm function on activities of daily living tasks before and after robot-assisted therapy. An affordable bilateral assessment system (BiAS) consisting of two mini-passive measuring units modeled as three degree of freedom robots is described. The process for evaluating functional tasks using the BiAS is presented and we demonstrate its ability to measure wrist kinematic trajectories. Three metrics, phase difference, movement overlap, and task completion time, are used to evaluate the BiAS system on a bilateral symmetric (bi-drink) and a bilateral asymmetric (bi-pour) functional task. Wrist position and velocity trajectories are evaluated using these metrics to provide insight into temporal and spatial bilateral deficits after stroke. The BiAS system quantified movements of the wrists during functional tasks and detected differences in impaired and unimpaired arm movements. Case studies showed that stroke patients compared to healthy subjects move slower and are less likely to use their arm simultaneously even when the functional task requires simultaneous movement. After robot-assisted therapy, interlimb coordination spatial deficits moved toward normal coordination on functional tasks

Space, time and number : common coding mechanisms and interactions between domains

Space, time and number are key dimensions that underlie how we perceive, identify and act within the environment. They are interconnected in our behaviour and brain. In this study, we examined interdependencies between these dimensions. To this end, left- and right-handed participants performed an object collision task that required space–time processing and arithmetic tests that involved number processing. Handedness of the participants influenced collision detection with left-handers being more accurate than right-handers, which is in line with the premise that hand preference guides individual differences as a result of sensorimotor experiences and distinct interhemispheric integration patterns. The data further showed that successful collision detection was a predictor for arithmetic achievement, at least in right-handers. These findings suggest that handedness plays a mediating role in binding information processing across domains, likely due to selective connectivity properties within the sensorimotor system that is guided by hemispheric lateralisation patterns.Peer reviewe

Upper-to-lower limb coordination dynamics in swimming depending on swimming speed and aquatic environment manipulations

Swimming is a challenging locomotion, involving the coordination of upper and lower limbs to propel the body forward in a highly resistive aquatic environment. During front crawl, freestyle stroke, alternating rotational motion of the upper limbs above and below the waterline, is coordinated with alternating lower limb pendulum actions. The aim of this study was to investigate the upper to lower limbs coordination dynamics of eight male elite front crawlers while increasing swimming speed and disturbing the aquatic environment (i.e., pool vs. flume). Upper to lower limb frequency ratios, coordination, coupling strength, and asymmetry were computed from data collected by inertial measurement units. Significant speed effect was observed, leading to transitions from 1∶1 to 1∶3 frequency ratios (1∶3 overrepresented), whereas 1∶2 frequency ratio was rarely used. Flume swimming led to a significant lower coupling strength at low speeds and higher asymmetries, especially at the highest speeds, probably related to the flume dynamic environment