589 research outputs found
FPGA configuration of an alloyed correlated branch predictor used with RISC processor for educational purposes
Instructions pipelining is one of the most outstanding techniques used in improving processor speed; nonetheless, these pipelined stages are constantly facing stalls that caused by nested conditional branches. During the execution of nested conditional branches, the behavior of the running branch depends on the history information of the previous ones; therefore, these branches have the greatest effect in reducing the prediction accuracy of a branch predictor among conditional branches. The purpose of this research is to reduce the stall cycles caused by correlated branches misprediction by introducing a hardware model of a branch predictor that combines both local and global prediction techniques. This predictor integrates the prediction characteristics of the alloyed predictor with those of the correlated predictor. the predictor design which implemented in VHDL (Very high-speed IC hardware description language) was inserted in previously designed MIPS (microprocessor without interlocked pipelined stages) processor and its prediction accuracy was confirmed by executing a program using the selection sort algorithm to sort 100 input numbers of different combinations ascendingly
Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide
BACKGROUND: For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission. In the absence of vaccines, topical microbicides, expected to block virus transmission, offer hope for controlling the pandemic. Antiretroviral chemotherapeutics have decreased AIDS mortality in industrialized countries, but only minimally in developing countries. To prevent an analogous dichotomy, microbicides should be: acceptable; accessible; affordable; and accelerative in transition from development to marketing. Already marketed pharmaceutical excipients or foods, with established safety records and adequate anti-HIV-1 activity, may provide this option. METHODS: Fruit juices were screened for inhibitory activity against HIV-1 IIIB using CD4 and CXCR4 as cell receptors. The best juice was tested for inhibition of: (1) infection by HIV-1 BaL, utilizing CCR5 as the cellular coreceptor; and (2) binding of gp120 IIIB and gp120 BaL, respectively, to CXCR4 and CCR5. To remove most colored juice components, the adsorption of the effective ingredient(s) to dispersible excipients and other foods was investigated. A selected complex was assayed for inhibition of infection by primary HIV-1 isolates. RESULTS: HIV-1 entry inhibitors from pomegranate juice adsorb onto corn starch. The resulting complex blocks virus binding to CD4 and CXCR4/CCR5 and inhibits infection by primary virus clades A to G and group O. CONCLUSION: These results suggest the possibility of producing an anti-HIV-1 microbicide from inexpensive, widely available sources, whose safety has been established throughout centuries, provided that its quality is adequately standardized and monitored
Effect of Nano SiO2 Particles on some Physical Properties of (UP/PU) Blend Composite
The effect of SiO2 physical properties (Shore D hardness, impact strength, 3 pts bending, thermal conductivity, and weight gain) after and before immersion in different liquid solution (water, HCL 0.2 N , and NaOH 0.2 N), of (UP/PU) blend was studied. Hand lay-up technique was applied using unsaturated polyester and polyurethane blend as a matrix and silicon oxide nano particles (Nano SiO2) as a filler with volume fraction (3% Vf ) . Results showed that liquids affected bending properties and thermal conductivity (k) by decreasing values, while the impact strength, and weight gain also studied for 4 weeks and it increase with increasing of immersion time in liquids
Recovering Jackknife Ridge Regression Estimates from OLS Results
The aim of this paper is addressing or recalculate the estimation methods in multiple linear regression model when there is a problem of Multicollinearity in this model like the ridge regression for Hoerl and Kannard, Baldwin estimator (HKB) and Jackknifed ridge regression estimator (JRR) using least-squares estimators which the last are the best unbiased estimators, consistent and linear. In this paper we proposed a formula to calculate the above estimators easily depending on the least-squares estimator, this treatment as a mathematical formula faster than the HKB estimator that depend on reducing the variance and JRR estimator that depend on reducing the bias. We used numerical examples of the pricing method in comprehensive quality and environmental quality as air pollution in places as pricing environment. After the comparison JRR and HKB estimates are superior to the OLS estimates under the mean squared error (MSE) criterion. 2000 Mathematics Subject Classification: Primary 62J07
Determination of the Antiprotozoal and Antibacterial Drug Metronidazole in Blood and Dosage Forms Using a Simple Spectrophotometric Method
A new, precise, and sensitive method for the determination of Metronidazole has been created. Metronidazole has been determined in both blood and dosage forms. The reaction is based on the reduction of the nitro group of metronidazole followed by coupling with the diazotized p-aminodiphenylamine to produce a soluble, colored complex measured at 515 nm. Beer-Lambert law is obeyed over the concentration range from 20 to 100 µg/mL, the molar absorptivity is 1397.88 L/mol.cm.The method has been used for the determination of metronidazole in the blood of the volunteer after 4, 6, 8, and 12 h from the administration of 500 mg tablet showing that the higher level of the drug was found after 6 h from swallowing the drug orally with excellent precision range (RSD% 0.0122-0.0387). The method has been also applied for the estimation of drug content in injection and tablet dosage forms with accuracy ranging from -4.1- to +4.0
HERMITE NUMERICAL METHOD TO ESTIMATE THE RADON AND RADIUM EFFECTS OF THE SOIL IN BARTELLA REGION
The Hermite numerical interpolation method used to estimate and predict the radon and radium concentrations, from some of the experimental measurements made on the soil samples of the Bartella region in Iraq. The results obtained from deductible mathematical method were close to real experimental results. Predicted results are in the range of 80.04–4051.59 Bq/m3radon concentrations and 0.322–17.276 Bq/Kgradium concentrations corresponding to 200-10000 tracks of alpha particles. The maximum errors were less than 0.289 and 1.172 percent for radon and radium concentrations, respectively. The effects of radium and radon radiations estimated of soil in the studied area depend on its concentrations, a higher number of alpha particle tracks mean high radiation concentration, the high radiation will cause human health damage. The values are below 370 Bq/Kg the recommended radium concentration permissible values, by the Organization ащк Economic Cooperation and Development (OECD), the studied area is safe from hazards on health of radium and radon exposure from the soi
Serological markers “CEA test & sAPRIL test” in Iraqi patients with colon cancer
Background: Colonic cancer is a very common disease world-wide being fourth most common cancer characterized by abnormal proliferation of the inner wall of colon then taking full colon wall thickness then spreading to surrounding lymph nodes and tissues and finally distant metastasis. It is one of most complicated diseases with debilitating symptoms which becomes more sever , prominent and specific with advancing stage with high percent of fatality and relatively short survival if diagnosed late or if left untreated.
Objective: To evaluate the efficacy of serum CEA & sAPRIL levels in the diagnosis and screening of colon cancer and their validity for this.
Patients and methods: This study was applied on 35 patients with colonic cancer, 35 patients with benign polyps and 15 negative controls. All individuals were subjected to blood sampling for measuring their serum CEA & sAPRIL using ELISA technique.
Results: In this study, majority of patients with colon cancer were presented at ages between 53-82 years of age (mean 68.5±6.4 years). Serum levels of sAPRIL & CEA were significantly elevated in those patients with advancing stages (C & D) compared with stages (A & B) and lower levels were found in patients who had surgical removal of tumor or received chemotherapy. Also a positive relation was found between sAPRIL & CEA with alcohol intake and smoking
Conclusion: according to this study sample it was found that sAPRIL and CEA together are strong indicators for colon cancer screening & diagnosis, and by this will reduce the need for more invasive screening & diagnostic tools
Effect of Glibenclamide and Tomato lycopene extract on some biochemical parameters in serum of alloxan Induced diabetic rabbits
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both, and occurs in almost all populations of the world a variable prevalence. In the present study we evaluated the effect of glibenclamide, and tomato lycopene extract on blood glucose, enzymatic antioxidants, glycated hemoglobin(HbA1c), and malondialdehyde(MDA) in 50 alloxan induced diabetic rabbits. The results showed a significant(P < 0.001) increase in the level of glucose, HbA1c, MDAin alloxan diabetic rabbits in comparison to the control rabbits. A Significant decrease in the level of serum glucose, HbA1c,and MDAin alloxan diabetic rabbits when received glibenclamide daily as single dose 0.5 mg/kg body weight for 20 weeks, and2and 4 mg/kg of tomato lycopene extract for 20 weeks respectively. The result of this study showed a significant (
Studying the Effect of Adding Up To 6wt%Cu on Some Mechanical and Physical Properties of Pure Aluminum
Aluminum and its alloys solidify in columnar structure with large grain size which results in deterioration of their surface quality and strength. Aluminum alloys with a wide range of properties are used in engineering structures. Copper has been the most common alloying element almost since the beginning of the aluminum industry, and a variety of alloys in which copper is the major addition were developed. In this work, the influence of pure copper addition to commercially pure aluminum hardness, compression strength and thermal conductivity were studied. Six different Al-Cu alloys with 1,2,3,4,5 and 6%Cu content were prepared and experimentally tested. It was found that adding up to 6wt%Cu led to linear increasing in Brinell hardness, compression strength and slightly increasing in the thermal conductivity of aluminum-copper alloys
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