The development of Cannabidiol as a psychiatric therapeutic:a review of its antipsychotic efficacy and possible underlying pharmacodynamic mechanisms

Cannabidiol (CBD), a once-considered inert cannabis constituent, is one of two primary constituents of cannabis, alongside delta-9-tetrahydrocannabinol (?9-THC/THC). In the last 30 years, CBD has become implicated with a range of pharmaceutical mechanisms of great therapeutic interest and utility. This review details the literature speculating CBD’s attenuation of psychotic symptoms, particularly in light of a marked elevation in mean THC concentrations, and a concomitant decline in CBD concentrations in the prevalent U.K street market cannabis derivatives since c. 2000. CBD is purported to exhibit pharmacology akin to established atypical antipsychotics, whilst THC has been implicated with the precipitation of psychosis, and the induction of associated symptoms. The aim of the review was to clarify the conjecture surrounding CBD’s antipsychotic efficacy, before going on to detail prominent theories about its associated pharmacodynamics. Were CBD’s antipsychotic efficacy established, then there is potential for major latent anthropological repercussions to manifest, such as significant elevations in psychosis manifestations in the U.K. The review found a largely affirmative body of evidence asserting CBD’s antipsychotic efficacy. CBD exhibited capacity to attenuate natural and artificially induced psychoses in both animal and human cohorts, the latter of which included individuals considered resistant to conventional treatment. CBD also shows promising potential for use as an antipsychotic drug for Parkinson’s disease (PD) patients with psychosis, owing to its low rate of extra-pyramidal side-effect induction. A range of potential pharmacological mechanisms behind CBD’s neuroleptic pharmacology are outlined, with particular emphasis on its prevention of the hydrolysis and reuptake of the endogenous cannabinoid, anandamide. However, given the nebular aetiological basis for psychoses, explicit conclusions on how CBD attenuates psychotic symptoms remains to be determined

Design and Implementation of Low Profile Antenna for Dual-Band Applications Using Rotated E-Shaped Conductor-Backed Plane

A novel configuration of a printed monopole antenna with a very compact size for satisfying WLAN operations at the 5.2/5.8 GHz and also for X-band operations at the 10 GHz has been proposed. The antenna includes a simple square-shaped patch as the radiator, the rotated U-shaped conductor back plane element with embedded strip on it, and the partial rectangular ground surface. By using the rotated U-shaped conductor-backed plane with proper values, good impedance matching and improvement in bandwidth can be achieved, at the lower and upper bands. The impedance bandwidth for S11<-10 dB is about 1.15 GHz for 5 GHz band and 5.3 GHz for X-band. The measured peak gains are about 1.9 dBi at WLAN-band and 4.2 dBi at X-band. The experimental results represent that the realized antenna with good omnidirectional radiation characteristics, enough impedance bandwidth, and reasonable gains can be appropriate for various applications of the future developed technologies and handheld devices

The Role of Metabolic Syndrome Components in Sensorineural Hearing Loss in Adolescents: A Case-Control Study

Introduction Metabolic syndrome (MetS) and its associated components were reported as a possible cause of inner ear dysfunction. However, research about the influence of cardiovascular risk factors on hearing thresholds are conducted mainly in adult patients