Synthesis of bis-oxathiaaza[3.3.3]propellanes via nucleophilic addition of (1,ω-alkanediyl)bis(N′-organylthioureas) on dicyanomethylene-1,3-indanedione

A concise and efficient route for synthesis of bis-oxathiaaza[3.3.3]propellanes by reaction of N,N,-N″-(1,ω-alkanediyl)bis-(N″-organylthioureas) with (1,3-dioxo-2,3-dihydro-1H-inden-2- ylidene)propanedinitrile is reported. The structures of the products have been confirmed by using NMR as well as single crystal X-ray analysis for one product. A plausible mechanism for formation of the products is presented.Peer reviewe

Geochemical anomalies in the igneous wall rock at Mayflower Mine, Park City District, Utah

Approximately 500 samples were collected from the igneous wall rock of the Mayflower Mine, Park City District, Utah. The mine is the sixth largest gold producer in the United States. The samples were analyzed for copper lead, zinc silver, manganese, sodium, potassium, calcium, magnesium and iron by atomic absorption spectrophotometry. Gold was determined by neutron activation analysis, silicon and sulfur by x-ray fluorescence spectrometery. The calculation of the mineral norm from the chemical analysis showed the wall rock to be of granodioritic composition. A study of selected vein samples indicates that the copper, silver and gold content in the veins increases to the eastern and northern part of the mine while lead and zinc show the opposite pattern. The trace element distribution in the wall rock was found to reflect this distribution. The lead and zinc aureoles were found to be confined to the immediate vein area. This indicates low mobility of the two elements. Copper, gold and silver show narrow aureoles in the western part of the mine. The aureoles become much wider in the eastern part where the concentrations in the veins are higher. The manganese aureole is most extensive in the western part where the manganese content of the vein is highest. High anomalous values of copper, lead and zinc in the wall rock coincide with the presence of the minerals chalcopyrite, galena and sphalerite respectively. The results indicate that the size of the trace element aureoles is affected mainly by the mobility of these elements and their concentration in the ore forming solution. Analysis of the wall rock for major elements shows addition of silica in the vein area and some leaching in the immediate wall rock. Aluminum and potassium are enriched in a zone extending 20 to 60 feet away from the vein. In this zone, calcium and sodium are leached. Magnesium and iron show an enrichment zone at some distance from the vein. In the eastern part of the mine alumino-silicate minerals are to some extent replaced by anhydrite, an observation which is also indicated by the very high sulfur values in the eastern wall rock traverses. Factor analysis of the major elements shows clearly the grouping of major elements into two major alteration zones, a potassium rich sericitic zone and a magnesium-iron rich chloritic zone --Abstract, pages ii-iii

Trace element anomalies in the igneous wall rocks of hydrothermal veins in the Searchlight District, Nevada

Two hundred and fifty vein and wall rock samples were collected from Chief of the Hill and the Duplex Mines of Searchlight District, Nevada. The samples were collected along lines approximately normal to the veins. They were analyzed for lead, copper, zinc, silver, gold, arsenic, selenium, and molybdenum using neutron actication analysis and atomic absorption spectrophotometry. Gold, silver, copper, lead and zinc show well-developed anomalies in the wall rocks. In most cases, the concentration of these elements decreases gradually with increasing distance from the vein and reaches background values at a distance of 40-120 feet from the vein. Molybdenum and selenium did not show a significant difference in concentration between vein material and wall rock. The arsenic concentration was below the detection limit of the used analytical method. The available results indicate that the concentration of metal in the vein strongly influences the extent of the wall rock anomaly. The results also indicate that anomalies are better developed in the hanging wall than in the footwall of a vein --Abstract, page ii

A convenient and efficient synthesis of thiazolidin-4-ones via cyclization of substituted hydrazinecarbothioamides

2-Substituted hydrazinecarbothioamides and N ,2-disubstituted hydrazinecarbothioamides react in high yield with dimethyl acetylenedicarboxylate (DMAD) to give 4-oxo-Z-(thiazolidin-5-ylidene) acetate derivatives. Several mechanistic options involving interaction are presented. The structures of thiazolidin-4-ones have been unambiguously confirmed by single crystal X-ray crystallography. (C) 2014 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.Peer reviewe

Reactivity of 2-substituted hydrazinecarbothioamides towards tetracyanoethylene and convenient synthesis of (5-amino-2-diazenylthiazolylmethylene) malononitrile derivatives

2-{Amino-[5-amino-2-(substituted diazenyl) thiazol-4-yl] methylene} malononitriles were synthesized from the reaction of 2-substituted hydrazinecarbothioamides with tetracyanoethylene (TCNE) to give tetracyanoethane adduct, followed by heterocyclization afforded the target compounds. The structure of (E)-2-{amino-[5-amino-2-(phenyldiazenyl) thiazol-4-yl] methylene} malononitrile was supported by single crystal X-ray crystallography.Peer reviewe

Reactivity of N-substituted alkenylidene hydrazinecarbothioamides toward tetracyanoethylene, an efficient synthesis stereoselective 1,3-thiazole compounds

The reaction between N-substituted alkenylidene hydrazinecarbothioamides and two molar amounts of tetracyanoethylene (TCNE) in anhydrous THF at room temperature without using any catalyst affords (Z)-4-amino-3-((Z)substituted amino)-2-(substituted imino)-2,3-dihydrothiazole-5-carbonitriles and (Z)-(4-amino-5-cyano-thiazol-2(3H)-ylidene)carbonhydrazonoyl dicyanides. Rationales for these transformations are presented. The structures of the obtained products were confirmed via single-crystal X-ray analyses. Graphic Here, we synthesize (Z)-4-amino-3-amino-2-imino-2,3-dihydrothiazole-5-carbonitriles and (Z)-(4-amino-5-cyano-thiazol-2(3H)-ylidene)carbonhydrazonoyl dicyanides from the reaction of N-substituted alkenylidene hydrazinecarbothioamides with (TCNE) in anhydrous THF at room temperature without using any catalyst. [GRAPHICS] .Peer reviewe

Synthesis and Biological activity of 1,3-Thiazolylidenehydrazinylidene ethylpyridiniumbromide monohydrate, 1,3-Thiazolylidenehydraziniumbromide and 1,3-Thiazolylidenehydrazine derivatives

1,3-Thiazolylidenehydrazinylidene ethylpyridinium bromide monohydrate, 1,3-thiazolylidenehydrazinium bromide and 1,3-thiazolylidenehydrazine derivatives were synthesized by heterocyclization of 2-(1-substituted ethylidene) hydrazinecarbothioamides, characterized and screened for their anti-bacterial activities. The structures of synthesized compounds were established by spectroscopic (IR, 1H, 13C-NMR, Mass) and X-ray analyses

Functionalized 1,3-Thiazolidin-4-Ones from 2-Oxo-Acenaphthoquinylidene- and [2.2]Paracyclophanylidene-Thiosemicarbazones

The reactions of dialkyl acetylenedicarboxylates with various 2-oxo-acenaphthoquinylidene- and 4-acetyl[2.2]paracyclophanylidene-thiosemicarbazones were investigated. Using simple experimental procedures, 1,3-Thiazolidin-4-ones derived from acenaphthequinone or [2.2]paracyclophane were obtained as major products in good yields. In the case of allyl derivative of acenaphthoquinylidene-thiosemicarbazones, a complex structure of tetramethyl 5-(2-(((Z,E)-N-allyl-N′-(2-oxoacenaphthylen-1(2H)-ylidene)carbamohydrazonoyl)thio)-1,2,3-tris-(methoxycarbonyl)-cyclopropyl)-4-methoxy-7-oxabicyclo[2.2.1]hepta-2,5-diene-1,2,3,6-tetracarboxylate was formed. Single crystal X-ray analysis was used as an efficient tool to confirm the structure of the synthesized compounds as well as different spectroscopic data (1H-NMR, 13C-NMR, 2D-NMR, mass spectrometry and elemental analysis). The mechanism of the obtained products was discussed

Functionalized 1,3-Thiazolidin-4-Ones from 2-Oxo-Acenaphthoquinylidene- and [2.2]Paracyclophanylidene-Thiosemicarbazones

The reactions of dialkyl acetylenedicarboxylates with various 2-oxo-acenaphthoquinylidene- and 4-acetyl[2.2]paracyclophanylidene-thiosemicarbazones were investigated. Using simple experimental procedures, 1,3-Thiazolidin-4-ones derived from acenaphthequinone or [2.2]paracyclophane were obtained as major products in good yields. In the case of allyl derivative of acenaphthoquinylidene-thiosemicarbazones, a complex structure of tetramethyl 5-(2-(((Z,E)-N-allyl-N′-(2-oxoacenaphthylen-1(2H)-ylidene)carbamohydrazonoyl)thio)-1,2,3-tris-(methoxycarbonyl)-cyclopropyl)-4-methoxy-7-oxabicyclo[2.2.1]hepta-2,5-diene-1,2,3,6-tetracarboxylate was formed. Single crystal X-ray analysis was used as an efficient tool to confirm the structure of the synthesized compounds as well as different spectroscopic data (1H-NMR, 13C-NMR, 2D-NMR, mass spectrometry and elemental analysis). The mechanism of the obtained products was discussed