The COVID-19 pandemic and young people's civic engagement: A scoping review

This scoping review summarizes evidence regarding the impact of civic and community engagement of young people during the COVID-19 pandemic. Recognizing that the global pandemic not only brought challenges but also new opportunities to take a stance and to actively engage in communities and society, this review assesses the impact of the COVID-19 pandemic on young people's civic engagement across different cultural contexts and identifies key factors and processes that enable young people to engage with their community or society at large. We summarize evidence from 27 original research papers, one thought piece, and four reports conducted by global organizations such as the United Nations and OECD. Relevant research was conducted in the United States, Europe, China, Southeast Asia, South Africa, and New Zealand, addressing the development of leadership skills, civic responsibility, critical consciousness, civic and community engagement, as well as social integration. Key factors that facilitated civic engagement include national investments in online learning facilities, support for basic needs (such as education, health, and employment), and promotion and encouragement of local initiatives. The studies differed in their focus depending on the socio-cultural context encountered and future research needs to consider cultural variations and different demands on young people to inform effective practices for supporting young people's active engagement in society

Defender or outsider? Understanding individual, social, and contextual factors in cyberbystander behavior in cyberaggression

Bystanders’ responses play an important role in cyberaggression incidents among youth. This study examines factors differentiating cyberbystander roles as defenders or outsiders. Individual factors (gender, age, self-efficacy, and digital skills), social factors (parent, teacher, and peer mediation), contextual factors (victim’s age relative to the bystander, perceived victim’s emotional (upset) response, and bystander-victim relationship quality), and types of incident modalities are explored. Data from 736 Czech adolescents ( M age = 14.4 years, SD age = 1.69, 51.9% boys) who acted as defenders or outsiders in cyberaggression incidents in the preceding year were analyzed using hierarchical binary logistic regression. Being a defender versus an outsider was significantly associated with younger age, active peer mediation, good relationship with the victim, higher perceived victim’s emotional (upset) response, and no video modality. The study underscores the multifaceted nature of online bystander behavior, offering insights for prevention and intervention targeting specific factors to promote defending behavior in adolescent cyberaggression

Alzheimer's disease-like perturbations in HIV-mediated neuronal dysfunctions: understanding mechanisms and developing therapeutic strategies

Excessive exposure to toxic substances or chemicals in the environment and various pathogens, including viruses and bacteria, is associated with the onset of numerous brain abnormalities. Among them, pathogens, specifically viruses, elicit persistent inflammation that plays a major role in Alzheimer's disease (AD) as well as dementia. AD is the most common brain disorder that affects thought, speech, memory and ability to execute daily routines. It is also manifested by progressive synaptic impairment and neurodegeneration, which eventually leads to dementia following the accumulation of Aβ and hyperphosphorylated Tau. Numerous factors contribute to the pathogenesis of AD, including neuroinflammation associated with pathogens, and specifically viruses. The human immunodeficiency virus (HIV) is often linked with HIV-associated neurocognitive disorders (HAND) following permeation through the blood-brain barrier (BBB) and induction of persistent neuroinflammation. Further, HIV infections also exhibited the ability to modulate numerous AD-associated factors such as BBB regulators, members of stress-related pathways as well as the amyloid and Tau pathways that lead to the formation of amyloid plaques or neurofibrillary tangles accumulation. Studies regarding the role of HIV in HAND and AD are still in infancy, and potential link or mechanism between both is not yet established. Thus, in the present article, we attempt to discuss various molecular mechanisms that contribute to the basic understanding of the role of HIV-associated neuroinflammation in AD and HAND. Further, using numerous growth factors and drugs, we also present possible therapeutic strategies to curb the neuroinflammatory changes and its associated sequels.Peer reviewe

Identification of QTLs associated with opaque2 modifiers influencing kernel opacity, kernel hardness, and tryptophan content in quality protein maize

Lysine and tryptophan, two essential amino acids, are generally deficient in normal maize but enriched in opaque2 (o2) mutants. However, these o2 mutants are linked to undesirable effects like soft endosperm and yield loss. To circumvent this, researchers introgressed o2 modifiers (Mo2s) into mutant maize and developed Quality Protein Maize (QPM). This study identifies genomic regions linked to Mo2 governing kernel hardness, opacity, and tryptophan content. Two QPM lines (DQL 2104–1 and DQL 2034), contrasting for these traits, were crossed to develop a 138 F2 and 109 F2:3 mapping population. Genotyping with 141 informative SSR markers resulted in 2417.01 cM genetic map with an average marker distance of 20.66 cM between markers. Inclusive composite interval mapping (ICIM) detected 11 QTLs across six different chromosomes: seven QTLs for kernel opacity (chromosomes 1, 2, 4, 7), three for hardness (chromosomes 7, 8, 9), and one for tryptophan (chromosome 9). These QTLs co-localized with candidate genes (opaque1, opaque11, floury1, floury2, floury4, mucronate1, and waxy1). The identified QTLs provide foundational targets for marker-assisted breeding. Few QTLs like qHRD9.1 (PVE = 14.18%) and qTRP9.1 (PVE = 10.69%) are prime candidates for improving hardness and tryptophan. These loci can be pyramided into elite lines using SSR markers; genomic selection could be used to optimize trait stacking. Future fine-mapping and functional studies will refine these regions, accelerating the development of high-yielding QPM with vitreous kernels and enhanced nutritional quality

The perceived vulnerability to disease scale: Cross‐cultural measurement invariance and associations with fear of COVID‐19 across 16 countries

Using cross‐sectional data from N = 4274 young adults across 16 countries during the COVID‐19 pandemic, we examined the cross‐cultural measurement invariance of the perceived vulnerability to disease (PVD) scale and tested the hypothesis that the association between PVD and fear of COVID‐19 is stronger under high disease threat [that is, absence of COVID‐19 vaccination, living in a country with lower Human Development Index (HDI) or higher COVID‐19 mortality]. Results supported a bi‐factor Exploratory Structural Equation Modeling model where items loaded on a global PVD factor, and on the sub‐factors of Perceived Infectability and Germ Aversion. However, cross‐national invariance could only be obtained on the configural level with a reduced version of the PVD scale (PVD‐r), suggesting that the concept of PVD may vary across nations. Moreover, higher PVD‐r was consistently associated with greater fear of COVID‐19 across all levels of disease threat, but this association was especially pronounced among individuals with a COVID‐19 vaccine, and in contexts where COVID‐19 mortality was high. The present research brought clarity into the dimensionality of the PVD measure, discussed its suitability and limitations for cross‐cultural research, and highlighted the pandemic‐related conditions under which higher PVD is most likely to go along with psychologically maladaptive outcomes, such as fear of COVID‐19