Mapping the sensitivity of split ring resonators using a localized analyte

Split ring resonator (SRR) based metamaterials have frequently been demonstrated for use as optical sensors of organic materials. This is made possible by matching the wavelength of the SRR plasmonic resonance with a molecular resonance of a specific analyte, which is usually placed on top of the metal structure. However, systematic studies of SRRs that identify the regions that exhibit a high electric field strength are commonly performed using simulations. In this paper we demonstrate that areas of high electric field strength, termed “hot-spots,” can be found by localizing a small quantity of organic analyte at various positions on or near the structure. Furthermore, the sensitivity of the SRR to the localized analyte can be quantified to determine, experimentally, suitable regions for optical sensing

Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)

Lactation is a key aspect of mammalian evolution for adaptation of various reproductive strategies along different mammalian lineages. Marsupials, such as tammar wallaby, adopted a short gestation and a relatively long lactation cycle, the newborn is immature at birth and significant development occurs postnatally during lactation. Continuous changes of tammar milk composition may contribute to development and immune protection of pouch young. Here, in order to address the putative contribution of newly identified secretory milk miRNA in these processes, high throughput sequencing of miRNAs collected from tammar milk at different time points of lactation was conducted. A comparative analysis was performed to find distribution of miRNA in milk and blood serum of lactating wallaby

Role of marsupial tammar wallaby milk in lung maturation of pouch young

Background: Marsupials such as the tammar wallaby (M.Eugenii) have a short gestation (29.3 days) and at birth the altricial young resembles a fetus, and the major development occurs postnatally while the young remains in the mother\u27s pouch. The essential functional factors for the maturation of the neonate are provided by the milk which changes in composition progressively throughout lactation (300 days). Morphologically the lungs of tammar pouch young are immature at birth and the majority of their development occurs during the first 100 days of lactation. Results: In this study mouse embryonic lungs (E-12) were cultured in media with tammar skim milk collected at key time points of lactation to identify factors involved in regulating postnatal lung maturation. Remarkably the embryonic lungs showed increased branching morphogenesis and this effect was restricted to milk collected at specific time points between approximately day 40 to 100 lactation. Further analysis to assess lung development showed a significant increase in the expression of marker genes Sp-C, Sp-B, Wnt-7b, BMP4 and Id2 in lung cultures incubated with milk collected at day 60. Similarly, day 60 milk specifically stimulated proliferation and elongation of lung mesenchymal cells that invaded matrigel. In addition, this milk stimulated proliferation of lung epithelium cells on matrigel, and the cells formed 3-dimensional acini with an extended lumen. Conclusions: This study has clearly demonstrated that tammar wallaby milk collected at specific times in early lactation contains bioactives that may have a significant role in lung maturation of pouch young

A QSO survey via optical variability and zero proper motion in the M92 field. IV. More QSOs due to improved photometry

We continue the QSO search in the 10 square degrees Schmidt field around M92 based on variability and proper motion (VPM) constraints. We have re-reduced 162 digitised B plates with a time-baseline of more than three decades and have considerably improved both the photometric accuracy and the star-galaxy separation at B>19. QSO candidates are selected and marked with one out of three degrees of priority based on the statistical significance of their measured variability and zero proper motion. Spectroscopic follow-up observations of 84 new candidates with B>19 revealed an additional 37 QSOs and 7 Seyfert1s. In particular, all 92 high-priority candidates are spectroscopically classified now; among them are 70 QSOs and 9 Seyfert1s (success rate 86%). We expect that 87% (55%) of all QSOs with B<19.0 (19.8) are contained in this high-priority subsample. For the combined sample of high-priority and medium-priority objects, a completeness of 89% is estimated up to B_lim=19.5. The sample of all AGNs detected in the framework of the VPM search in the M92 field contains now 95 QSOs and 14 Seyfert1s with B<19.9. Although the VPM QSOs were selected by completely different criteria, their properties do not significantly differ from those of QSOs found by more traditional optical survey techniques. In particular, the spectra and the optical broad band colours do not provide any hints on a substantial population of red QSOs up to the present survey limit.Comment: 13 pages, 12 figures, accepted for publication in Astronomy and Astrophysic

Terrestrial exposure of a fresh Martian meteorite causes rapid changes in hydrogen isotopes and water concentrations

Determining the hydrogen isotopic compositions and H2O contents of meteorites and their components is important for addressing key cosmochemical questions about the abundance and source(s) of water in planetary bodies. However, deconvolving the effects of terrestrial contamination from the indigenous hydrogen isotopic compositions of these extraterrestrial materials is not trivial, because chondrites and some achondrites show only small deviations from terrestrial values such that even minor contamination can mask the indigenous values. Here we assess the effects of terrestrial weathering and contamination on the hydrogen isotope ratios and H2O contents of meteoritic minerals through monitored terrestrial weathering of Tissint, a recent Martian fall. Our findings reveal the rapidity with which this weathering affects nominally anhydrous phases in extraterrestrial materials, which illustrates the necessity of sampling the interiors of even relatively fresh meteorite falls and underlines the importance of sample return missions

The Malagarasi River Does Not Form an Absolute Barrier to Chimpanzee Movement in Western Tanzania

The Malagarasi River has long been thought to be a barrier to chimpanzee movements in western Tanzania. This potential geographic boundary could affect chimpanzee ranging behavior, population connectivity and pathogen transmission, and thus has implications for conservation strategies and government policy. Indeed, based on mitochondrial DNA sequence comparisons it was recently argued that chimpanzees from communities to the north and to the south of the Malagarasi are surprisingly distantly related, suggesting that the river prevents gene flow. To investigate this, we conducted a survey along the Malagarasi River. We found a ford comprised of rocks that researchers could cross on foot. On a trail leading to this ford, we collected 13 fresh fecal samples containing chimpanzee DNA, two of which tested positive for SIVcpz. We also found chimpanzee feces within the riverbed. Taken together, this evidence suggests that the Malagarasi River is not an absolute barrier to chimpanzee movements and communities from the areas to the north and south should be considered a single population. These results have important consequences for our understanding of gene flow, disease dynamics and conservation management

Entomological Surveillance of Behavioural Resilience and Resistance in Residual Malaria Vector Populations.

The most potent malaria vectors rely heavily upon human blood so they are vulnerable to attack with insecticide-treated nets (ITNs) and indoor residual spraying (IRS) within houses. Mosquito taxa that can avoid feeding or resting indoors, or by obtaining blood from animals, mediate a growing proportion of the dwindling transmission that persists as ITNs and IRS are scaled up. Increasing frequency of behavioural evasion traits within persisting residual vector systems usually reflect the successful suppression of the most potent and vulnerable vector taxa by IRS or ITNs, rather than their failure. Many of the commonly observed changes in mosquito behavioural patterns following intervention scale-up may well be explained by modified taxonomic composition and expression of phenotypically plastic behavioural preferences, rather than altered innate preferences of individuals or populations. Detailed review of the contemporary evidence base does not yet provide any clear-cut example of true behavioural resistance and is, therefore, consistent with the hypothesis presented. Caution should be exercised before over-interpreting most existing reports of increased frequency of behavioural traits which enable mosquitoes to evade fatal contact with insecticides: this may simply be the result of suppressing the most behaviourally vulnerable of the vector taxa that constituted the original transmission system. Mosquito taxa which have always exhibited such evasive traits may be more accurately described as behaviourally resilient, rather than resistant. Ongoing national or regional entomological monitoring surveys of physiological susceptibility to insecticides should be supplemented with biologically and epidemiologically meaningfully estimates of malaria vector population dynamics and the behavioural phenotypes that determine intervention impact, in order to design, select, evaluate and optimize the implementation of vector control measures

A slitless spectroscopic survey for quasars near quasars

We present the results of the Quasars near Quasars (QNQ) survey, a CCD-based slitless spectroscopic survey for faint V<22 quasars at 1.7<z<3.6 on 18 26.2'x33.5' fields centred on bright quasars at 2.76<z<4.69. In total 169 quasar candidates with emission lines were selected from the extracted flux-calibrated spectra on the basis of well-defined automatic selection criteria followed by visual inspection and verification. With follow-up spectroscopy of 81 candidates that were likely to reside at z>1.7 we were able to confirm 80 new quasars at 0.580<z<3.586 on 16 of our fields. 64 of the newly discovered quasars are located at z>1.7. The overall high success rate implies that most of the remaining 88 candidates are quasars as well, although the majority of them likely resides at z<1.7 on the basis of the observed line shapes and strengths. Due to the insufficient depth of the input source catalogues needed for extraction of the slitless spectra our survey is not well defined in terms of limiting magnitude for faint 2.5<z<3.6 quasars whose Lyman alpha emission is detectable well beyond V=22, albeit at a continuum S/N<1. While not useful for characterising the evolving space density of quasars, our sample provides many new closely spaced quasar sightlines around intensely studied quasars for further investigations on the three-dimensional distribution of the intergalactic medium.Comment: 18 pages, 16 figures, accepted by A&A, includes Table 2 from online material, full paper with appendices containing additional figures and tables available at http://www.aip.de/People/gworseck/qnqpaper/qnqpaper_final.pd

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension. A role for local glucocorticoid reamplification in obesity and the metabolic syndrome has been suggested. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active cortisol from inactive 11-keto forms, and aP2-HSD1 mice with relative transgenic overexpression of this enzyme in fat cells develop visceral obesity with insulin resistance and dyslipidemia. Here we report that aP2-HSD1 mice also have high arterial blood pressure (BP). The mice have increased sensitivity to dietary salt and increased plasma levels of angiotensinogen, angiotensin II, and aldosterone. This hypertension is abolished by selective angiotensin II receptor AT-1 antagonist at a low dose that does not affect BP in non-Tg littermates. These findings suggest that activation of the circulating renin-angiotensin system (RAS) develops in aP2-HSD1 mice. The long-term hypertension is further reflected by an appreciable hypertrophy and hyperplasia of the distal tubule epithelium of the nephron, resembling salt-sensitive or angiotensin II–mediated hypertension. Taken together, our findings suggest that overexpression of 11β-HSD1 in fat is sufficient to cause salt-sensitive hypertension mediated by an activated RAS. The potential role of adipose 11β-HSD1 in mediating critical features of the metabolic syndrome extends beyond obesity and metabolic complications to include the most central cardiovascular feature of this disorder

Optical identification of XMM sources in the CFHTLS

We present optical spectroscopic identifications of X-ray sources in ~3 square degrees of the XMM-Large Scale Structure survey (XMM-LSS), also covered by the Canada France Hawaii Telescope Legacy Survey (CFHTLS), obtained with the AAOmega instrument at the Anglo Australian Telescope. In a flux limited sample of 829 point like sources in the optical band with g' <~22 mag and the 0.5-2 keV flux > 1x10^{-15}erg/cm^2/s, we observed 695 objects and obtained reliable spectroscopic identification for 489 sources, ~59% of the overall sample. We therefore increase the number of identifications in this field by a factor close to five. Galactic stellar sources represent about 15% of the total (74/489). About 55% (267/489) are broad-line Active Galactic Nuclei (AGNs) spanning redshifts between 0.15 and 3.87 with a median value of 1.68. The optical-to-X-ray spectral index of the broad-line AGNs is 1.47, typical of optically-selected Type I quasars and is found to correlate with the rest frame X-ray and optical monochromatic luminosities at 2 keV and 2500 angstroms respectively. Consistent with previous studies, we find alpha_ox not to be correlated with z. In addition, 32 and 116 X-ray sources are, respectively absorption and emission-line galaxies at z<0.76. From a line ratio diagnostic diagram it is found that in about 50% of these emission line galaxies, the emission lines are powered significantly by the AGN. Thirty of the XMM sources are detected at one or more radio frequencies. In addition, 24 sources have ambiguous identification: in 8 cases, two XMM sources have a single optical source within 6 arcsecs of each of them, whereas, 2 and 14 XMM sources have, respectively, 3 and 2 possible optical sources within 6 arcsecs of each of them.Comment: 15 pages, 14 figures, 5 tables, accepted for publication in MNRA