Digital Map Rendering Method

The invention is a system and method of compressing terrain data to be used to render a three-dimensional map representation of the terrain data. In general, the invention operates by first selecting the boundaries of the terrain data and to be compressed and dividing the terrain data into regular geometric areas. Next, a type of free-edged, planar geometric surface is defined which is used to approximate the terrain data for each regular geometric area. The approximations are checked to determine if they fall within user selected tolerances. If the approximation for a specific regular geometric area is within the user specified tolerances, the data is saved for that specific regular geometric area. If the approximation for a specific regular geometric area falls outside the user specified tolerances, the regular geometric area is divided and a free-edged, planar geometric surface approximation is made for each of the divided areas. This process is recursively repeated until all of the regular geometric areas are approximated by free-edged, planar surfaces. Finally, the compressed terrain data is used to render a three-dimensional map

Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

Previous genome-wide association studies (GWAS) of prostate cancer risk focused on cases unselected for family history and have reported over 100 significant associations. The International Consortium for Prostate Cancer Genetics (ICPCG) has now performed a GWAS of 2511 (unrelated) familial prostate cancer cases and 1382 unaffected controls from 12 member sites. All samples were genotyped on the Illumina 5M+exome single nucleotide polymorphism (SNP) platform. The GWAS identified a significant evidence for association for SNPs in six regions previously associated with prostate cancer in population-based cohorts, including 3q26.2, 6q25.3, 8q24.21, 10q11.23, 11q13.3, and 17q12. Of note, SNP rs138042437 (p = 1.7e−8) at 8q24.21 achieved a large estimated effect size in this cohort (odds ratio = 13.3). 116 previously sampled affected relatives of 62 risk-allele carriers from the GWAS cohort were genotyped for this SNP, identifying 78 additional affected carriers in 62 pedigrees. A test for an excess number of affected carriers among relatives exhibited strong evidence for co-segregation of the variant with disease (p = 8.5e−11). The majority (92 %) of risk-allele carriers at rs138042437 had a consistent estimated haplotype spanning approximately 100 kb of 8q24.21 that contained the minor alleles of three rare SNPs (dosage minor allele frequencies <1.7 %), rs183373024 (PRNCR1), previously associated SNP rs188140481, and rs138042437 (CASC19). Strong evidence for co-segregation of a SNP on the haplotype further characterizes the haplotype as a prostate cancer pre-disposition locus

Rumination about racial privilege

We will examine whether ruminating about racial privilege maintains levels of anger and guilt compared to distraction and whether these emotions, in turn, are associated with support for racial equality

Feminist women's evaluations of male allies who deny their privilege

Men can be effective allies in the fight for gender equality. Feminist women generally evaluate men who fight for gender equality positively (Wiley &amp; Dunne, 2019), even as they stigmatize them as feminine (Anderson, 2009; Rudman, Mescher, &amp; Moss-Rascusin). However, sometimes ally men engage in behavior that can be harmful and that can undermine the fight for equality (Carton &amp; Knowlton, 2017). In the present study we examine whether personal denial of gender privilege moderates the morality feminist women attribute to ally men, and through it, feminist women's orientations towards and feelings of empowerment by ally men. Privilege is a threat to advantaged group members’ (e.g., men’s) identities and some allies are motivated to deny it (Knowles et al., 2014). In so doing, they may diminish men’s potential contributions to the feminist movement