Psychosocial functioning in patients with treatment-resistant depression after group cognitive behavioral therapy

<p>Abstract</p> <p>Background</p> <p>Although patients with Treatment Resistant Depression (TRD) often have impaired social functioning, few studies have investigated the effectiveness of psychosocial treatment for these patients. We examined whether adding group cognitive behavioral therapy (group-CBT) to medication would improve both the depressive symptoms and the social functioning of patient with mild TRD, and whether any improvements would be maintained over one year.</p> <p>Methods</p> <p>Forty-three patients with TRD were treated with 12 weekly sessions of group-CBT. Patients were assessed with the Global Assessment of Functioning scale (GAF), the 36-item Short-Form Health Survey (SF-36), the Hamilton Rating Scale for Depression (HRSD), the Dysfunctional Attitudes Scale (DAS), and the Automatic Thought Questionnaire-Revised (ATQ-R) at baseline, at the termination of treatment, and at the 12-month follow-up.</p> <p>Results</p> <p>Thirty-eight patients completed treatment; five dropped out. For the patients who completed treatment, post-treatment scores on the GAF and SF-36 were significantly higher than baseline scores. Scores on the HRSD, DAS, and ATQ-R were significantly lower after the treatment. Thus patients improved on all measurements of psychosocial functioning and mood symptoms. Twenty patients participated in the 12-month follow-up. Their improvements for psychosocial functioning, depressive symptoms, and dysfunctional cognitions were sustained at 12 months following the completion of group-CBT.</p> <p>Conclusions</p> <p>These findings suggest a positive effect that the addition of cognitive behavioural group therapy to medication on depressive symptoms and social functioning of mildly depressed patients, showing treatment resistance.</p

Increased amygdala reactivity following early life stress : a potential resilience enhancer role

Background: Amygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was negatively or positively associated with depressive symptoms and impact of negative life event stress in never-depressed adults. Methods: Twenty-four healthy participants completed an individually tailored negative mood induction task during functional magnetic resonance imaging (fMRI) assessment along with evaluation of ELS. Results: Mood change and amygdala reactivity were increased in never-depressed participants who reported ELS compared to participants who reported no ELS. Yet, increased amygdala reactivity lowered effects of ELS on depressive symptoms and negative life events stress. Amygdala reactivity also had positive functional connectivity with the bilateral DLPFC, motor cortex and striatum in people with ELS during sad memory recall. Conclusions: Increased amygdala activity in those with ELS was associated with decreased symptoms and increased neural features, consistent with emotion regulation, suggesting that preservation of robust amygdala reactions may reflect a stress buffering or resilience enhancing factor against depression and negative stressful events

Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer : A case report and literature review

Denosumab, a human monoclonal antibody directed against the receptor activator of nuclear factor-κβ ligand (RANKL), is used for the treatment of patients with metastatic cancer of the bone or osteoporosis. Recent reports have demonstrated that denosumab can induce osteonecrosis of the jaw (ONJ), but reported cases of this are uncommon. The present study reports the case of an 86-year-old male with prostate cancer patient exhibiting bone metastases who developed ONJ whilst receiving denosumab. To elucidate the influence of denosumab on the development of ONJ, the present study also reviewed the literature, including clinical trials and case reports. In the clinical trials, the prevalence of denosumab-related ONJ was higher in patients with cancer compared with those with osteoporosis. The high risk of ONJ in patients with cancer was thought to be associated with the differing dose and frequency of denosumab administration. The prevalence of ONJ was not significantly different between patients receiving denosumab and bisphoshonate (BP). In the reported cases, denosumab-related ONJ had a similar clinical presentation to BP-related ONJ. There was also a tendency for denosumab-related ONJ to develop in the mandible of elderly patients. Previous invasive dental treatment was a commonly shared characteristic of patients with denosumab-related ONJ. A complex medical history was also suspected to affect the prevalence. No clear association between the dose or duration of denosumab treatment and the development of ONJ was observed. Although conservative treatments are given for denosumab-related ONJ, non-improving cases were managed surgically with primarily positive results. Because denosumab may offer superior results compared with BP for the treatment of metastatic cancer of the bone or osteoporosis, the use of denosumab is expected to increase in the near future. Clinicians should also be aware of the risk factors for denosumab-related ONJ, in order to aid in its diagnosis. In addition, patients treated with denosumab should receive prophylactic treatment to maintain their oral health prior to, during and after denosumab treatment.thesi

The Effect of Negative and Positive Emotionality on Associative Memory: An fMRI Study

In general, emotion is known to enhance memory processes. However, the effect of emotion on associative memory and the underling neural mechanisms remains largely unexplored. In this study, we explored brain activation during an associative memory task that involved the encoding and retrieval of word and face pairs. The word and face pairs consisted of either negative or positive words with neutral faces. Significant hippocampal activation was observed during both encoding and retrieval, regardless of whether the word was negative or positive. Negative and positive emotionality differentially affected the hemodynamic responses to encoding and retrieval in the amygdala, with increased responses during encoding negative word and face pairs. Furthermore, activation of the amygdala during encoding of negative word and neutral face pairs was inversely correlated with subsequent memory retrieval. These findings suggest that activation of the amygdala induced by negative emotion during encoding may disrupt associative memory performance

The effect of induced optimism on the optimistic update bias

Abstract Background Individuals tend to have an optimism bias, processing desirable information more frequently than undesirable information. However, people who have been diagnosed with depression often have a more pessimistic view of the future. A recent study suggests that future expectations in individuals with dysphoria become more optimistic when asked to make optimistic future predictions about the future. In the present study, we investigated the differential effects of induced optimism training which making optimistic future prediction to change future beliefs in normal participants with various levels of dysphoria (low, mild, high). Methods We recruited normal participants (n = 69) from a local university students and divided participants into three groups (low, mild, high dysphoria) by measuring dysphoric mood. These three groups were assigned to the induced optimism training or control condition. After the training, participants performed the two-stage belief updating task. In the first stage, participants estimated their personal probability of experiencing adverse events while being presented with the average probability of the event occurring to a living person. This information could be desirable for participants(when presented with a probability that was below their estimation) or undesirable (when presented with a probability that was above their estimation). To assess how desirable versus undesirable information influenced beliefs, participants estimated their personal probability of experiencing the events again in the second stage. The amount of update error was calculated as the difference between the estimates in the first stage and the second stage. The difference between the errors was classified as the update bias. Results After the induced optimism training, individuals with the mild dysphoria demonstrated a higher update bias than low (p &lt; .001) and the high dysphoria (p &lt; .05) group in induced optimism condition. Significant differences were not found in control group. Results indicates that individuals in the mild dysphoria group showed an increased update bias after being exposed to the induced optimism training Dysphoric mood and trait optimism remained unchanged in both the experimental and control groups. Conclusions Results suggest that induced optimism training has potential to change individuals with mild dysphoria perceptions’ about the future. </jats:sec

Personal identification with artificial intelligence under COVID-19 crisis: a scoping review

Abstract Background Artificial intelligence is useful for building objective and rapid personal identification systems. It is important to research and develop personal identification methods as social and institutional infrastructure. A critical consideration during the coronavirus disease 2019 pandemic is that there is no contact between the subjects and personal identification systems. The aim of this study was to organize the recent 5-year development of contactless personal identification methods that use artificial intelligence. Methods This study used a scoping review approach to map the progression of contactless personal identification systems using artificial intelligence over the past 5 years. An electronic systematic literature search was conducted using the PubMed, Web of Science, Cochrane Library, CINAHL, and IEEE Xplore databases. Studies published between January 2016 and December 2020 were included in the study. Results By performing an electronic literature search, 83 articles were extracted. Based on the PRISMA flow diagram, 8 eligible articles were included in this study. These eligible articles were divided based on the analysis targets as follows: (1) face and/or body, (2) eye, and (3) forearm and/or hand. Artificial intelligence, including convolutional neural networks, contributed to the progress of research on contactless personal identification methods. Conclusions This study clarified that contactless personal identification methods using artificial intelligence have progressed and that they have used information obtained from the face and/or body, eyes, and forearm and/or hand. </jats:sec

Maxillary third molars with horizontal impaction: A cross-sectional study using computed tomography in young Japanese patients

Objective To examine the anatomical characteristics of impacted maxillary third molars to help predict and prevent possible adverse events during extraction. Methods This retrospective study enrolled young Japanese patients that were assessed for third molar extraction. Patients with maxillary third molar impaction presenting with no space between the maxillary second molar and the occlusal surface of the maxillary third molar were analysed using computed tomography data. Results In this study, a total of 663 patients aged 20–29 years were examined for third molar extraction and 26 teeth in 23 patients were analysed. The mean ± SD angle between the second and third molar axes was 54.2° ± 7.5° and the mean ± SD length of the maxillary third molar was 16.1 ± 1.9 mm. The maxillary third molars showed close or extensive contact with the maxillary sinus and computed tomography did not show any bone from the maxillary sinus floor. Furthermore, in all patients, the crowns of the third molars were not completely covered by the alveolar bone. Conclusions Maxillary third molars with horizontal impaction showed close or extensive contact with the maxillary sinus and their crowns were not completely covered by the alveolar bone. </jats:sec