Music Therapy Techniques for Memory Stabilization in Diverse Dementias

Music contains certain unmistakable healing properties pertaining specifically to the matured body and soul affected by various types of dementia. Music therapy aids in memory retention or the retarding of the loss of mental function as a result of Alzheimer\u27s disease, Dementia with Lewy bodies, and Senile Dementia. Music can help subjects access lost memories through interaction with a music therapist. Certain music therapy techniques have been shown to yield additional physical, communicative, and psychological benefits. The disease progress of Alzheimer\u27s disease, Dementia with Lewy bodies, and Senile Dementia may be further delayed by music therapy when paired with pharmaceutical interventions such as previously established memory enhancing medications

Veto Players and Policy Entrepreneurship

Political institutions often use decision making procedures that create veto players—individuals or groups who, despite lacking direct decision making authority, nevertheless have the power to block policy change. In this paper we use the competitive policy development model of Hirsch and Shotts (2015) to examine how the presence of veto players effects outcomes when policies are developed endogenously. Consistent with spatial models of pivotal politics, veto players can induce gridlock, which is harmful to a centrist decisionmaker. But they can also have more subtle effects. Some of the effects are negative—for example, when the status quo is centrist, veto players dampen productive policy competition because of their resistance to change. But some of the effects are surprisingly positive. In particular, when the status quo benefits a veto player and there is a skilled policy entrepreneur who is highly motivated change it, the veto player forces the entrepreneur to develop a much higher quality proposal. This effect yields substantial benefits for a centrist decisionmaker. We also show that veto players can induce asymmetric patterns of policy development, with much greater activity by the faction that is more dissatisfied with the status quo

Policy-Specific Information and Informal Agenda Power

In Gilligan and Krehbiel's models of procedural choice in legislatures, a committee exerts costly effort to acquire private information about an unknown state of the world. Subsequent work on expertise, delegation, and lobbying has largely followed this approach. In contrast, we develop a model of information as policy valence. We use our model to analyze a procedural choice game, focusing on the effect of transferability, i.e., the extent to which information acquired to implement one policy option can be used to implement a different policy option. We find that when information is transferable, as in Gilligan and Krehbiel's models, closed rules can induce committee specialization. However, when information is policy‐specific, open rules are actually superior for inducing specialization. The reason for this surprising result is that a committee lacking formal agenda power has a greater incentive to exercise informal agenda power by exerting costly effort to generate high‐valence legislation

Competitive Policy Development

We present a model of policy development in which competing factions have different ideologies, yet agree on certain common objectives. Policy developers can appeal to a decision maker by making productive investments to improve the quality of their proposals. These investments are specific to a given proposal, which means that policy developers can potentially obtain informal agenda power. Competition undermines this agenda power, forcing policy developers to craft policies that are better for the decision maker. This beneficial effect is strongest if policy developers have divergent ideological preferences, because their intense desire to affect policy motivates them to develop higher quality proposals

A study of lunar resources - A preliminary report of surface and some other mining systems Summary report, 22 May 1965 - 1 May 1966

Use of extraterrestrial resources in lunar and planetary exploratio

Pulsed Energy Systems for Generating Plasmas

This paper will describe the techniques needed to electrically generate highly ionized dense plasmas for a variety of applications. The components needed in pulsed circuits are described in terms of general performance parameters currently available from commercial vendors. Examples of pulsed systems using these components are described and technical data from laboratory experiments presented. Experimental data are given for point designs, capable of multi-megawatt power levels

The mechanism by which potassium causes neurite retraction in lamprey descending neurons in cell culture

Abstract only availableSevere spinal cord injury (SCI) disrupts descending axons from reticulospinal (RS) neurons that project to the spinal cord. In most “higher” vertebrates, including humans, recovery is very minimal due to limited regeneration in the central nervous system, and paralysis is usually permanent below the injury site. In several lower vertebrates, including the lamprey, behavioral recovery is almost complete following SCI due to robust axonal regeneration. To study the cellular and molecular mechanisms that regulate axonal regeneration, neurons are often isolated in cell culture so that the factors that influence neurite outgrowth can be studied under controlled conditions. In our laboratory, we have developed a cell culture system in which neurite outgrowth of RS neurons can be studied (Hong et al., 2002; Ryan et al., 2004). Application of glutamate, an excitatory neurotransmitter, to the growth cones of RS neurons results in neurite retraction, presumably because of depolarization, calcium influx, and an increase in intracellular calcium. Intracellular calcium is thought to be one of the important regulators of the rate and direction of neurite outgrowth. Calcium influx could result from at least two different channels: chemically-gated channels (e.g. NMDA channels); or voltage-gated calcium channels. The purpose of the present study was to determine if calcium influx via voltage-gated calcium channels is sufficient to elicit neurite retraction. First, focal application of a 31 M potassium to growth cones of DiI-labeled RS neurons in culture to open voltage-gated calcium channels significantly reduced neurite growth rates, including neurite retraction, compared to pre-control periods. Second, 2 of Co++ or 300 M Cd++, which block calcium channels, abolished potassium-induced neurite retraction. In conclusion, the results suggest that calcium influx via voltage-gated calcium channels is sufficient to cause neurite retraction. Other experiments will determine if influx through voltage-gated channels is necessary for glutamate to elicit neurite outgrowth. Determination of the factors that regulate neurite outgrowth may provide information about the mechanism by which RS neurons regenerate their axons following spinal cord injury and restore locomotor function.Life Sciences Undergraduate Research Opportunity Progra

A Consensus on Second Stage Analyses in Ecological Inference Models

Statistic

Evidence that glutamate induced neurite retraction of reticulospinal neurons is dependent on calcium influx

Abstract only availableLocomotor systems of vertebrates consist of a command system in the brain that activates central pattern generators in the spinal cord to initiate locomotor behavior. Reticulospinal (RS) neurons are the output neural elements of the command system. Following spinal cord injury, axons of RS neurons are severed and must regenerate to restore behavioral functions below the lesion. In higher vertebrates, such as birds and mammals, axonal regeneration is very limited, and spinal cord injury usually results in permanent paralysis below the lesion. In contrast, in the lamprey and a few other lower vertebrates, axonal regeneration is robust following spinal cord injury, and this results in virtually complete behavioral recovery. Therefore, identification of the mechanisms for axonal regeneration in lower vertebrates might provide information about the requirements for regenerating neurons in higher vertebrates. Examination of neurite outgrowth in culture is often used to identify the cellular and molecular mechanisms for axonal regeneration. In our laboratory, we have shown that application of glutamate, an excitatory neurotransmitter, to growth cones of RS neurons in culture causes neurite retraction, presumably by causing depolarization and calcium influx. Intracellular calcium levels are thought to be one of the important regulatory factors for neurite outgrowth. Glutamate might mediate calcium influx via at least two types of channels: chemically-gated channels (e.g. NMDA channels); or voltage-gated calcium channels. The purpose of the present study was to determine if calcium influx via voltage-gated channels is necessary for neurite retraction. The anatomical tracer DiI was applied to the spinal cord to pre-label RS neurons. Following transport, RS neurons were isolated and placed in cell culture. Glutamate was pressure ejected onto the growth cones of RS neurons in the presence of w-conotoxin MVIIC, which is a specific blocker for N and P voltage-gated calcium channels. Under these conditions, conotoxin reduced but did not block glutamate-induced neurite retraction. In conclusion, glutamate-induced neurite retraction of lamprey RS neurons probably is mediated by calcium influx via both chemically-gated and voltage-gated channels. Determination of the factors that regulate neurite outgrowth in culture may provide insights into the mechanisms for axonal regeneration and behavioral recovery following spinal cord injury in whole animals.Life Sciences Undergraduate Research Opportunity Progra

A Comparison of Network Sampling Designs for a Hidden Population of Drug Users: Random Walk vs. Respondent-Driven Sampling

Both random walk and respondent-driven sampling (RDS) exploit social networks and may reduce biases introduced by earlier methods for sampling from hidden populations. Although RDS has become much more widely used by social researchers than random walk (RW), there has been little discussion of the tradeoffs in choosing RDS over RW. This paper compares experiences of implementing RW and RDS to recruit drug users to a network-based study in Houston, Texas. Both recruitment methods were implemented over comparable periods of time, with the same population, by the same research staff. RDS methods recruited more participants with less strain on staff. However, participants recruited through RW were more forthcoming than RDS participants in helping to recruit members of their social networks. Findings indicate that, dependent upon study goals, researchers' choice of design may influence participant recruitment, participant commitment, and impact on staff, factors that may in turn affect overall study success