Flavonoids Biosynthesis in Plants as a Defense Mechanism: Role and Function Concerning Pharmacodynamics and Pharmacokinetic Properties

Flavonoids are a major class of secondary metabolites that comprises more than 6000 compounds that have been identified. They are biosynthesized via the phenylpropanoid metabolic pathway that involves groups of enzymes such as isomerases, hydroxylases, and reductases that greatly affect the determination of the flavonoid skeleton. For example, transferase enzymes responsible for the modification of sugar result in changes in the physiological activity of the flavonoids and changes in their physical properties, such as solubility, reactivity, and interaction with cellular target molecules, which affect their pharmacodynamics and pharmacokinetic properties. In addition, flavonoids have diverse biological activities such as antioxidants, anticancer, and antiviral in managing Alzheimer’s disease. However, most marine flavonoids are still incompletely discovered because marine flavonoid biosynthesis is produced and possesses unique substitutions that are not commonly found in terrestrial bioactive compounds. The current chapter will illustrate the importance of flavonoids’ role in metabolism and the main difference between marine and terrestrial flavonoids

Biogenic Silver Nanoparticles Synthesis from New Record Aquatic Bacteria of Nile Tilapia and Evaluation of their Biological Activity

The current study investigates the isolation identification of bioactive strain from fish collected from El-Burrllus region in Egypt. The objective of the current study is to identify and assess the biological profile of a new record strain in Egypt Bacillus maritimus. The molecular identification of the selected promising isolate and phylogenetic analysis confirmed the accurate identity of the isolate as Bacillus maritimus. The novelty of the present study was not due to only to the fact that the Bacillus maritimus isolate was the first record from brackish-water Egyptian fish gut, but also due to the fact that there is no previous study on the bioactivity of Bacillus maritimus and their efficiency as biogenic nanoparticles synthesis. The bioactivities for the Bacillus maritimus were investigated through different biochemical assays as antioxidant, anti-inflammatory and antimicrobial activity against six of the tested human pathogens namely; Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 8739, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 15442, Klebsiella pneumoniae ATCC 13883 and Streptococcus pyogenes ATCC 19615. Bacillus maritimus bacteria were grown in nutrient broth for 24 h at 37°C and the optical density was determined at 600 nm using the UV-visible spectrophotometer. The optical density (OD) of the broth was adjusted to 0.5 with sterile phosphate-buffered saline, pH 7.4 (PBS). the bacterial isolate showed antioxidant, and anti-inflammatory activities. In addition the bacteria showed great reducing agent ability as a biogenic agent for the silver nanoparticles. The phytochemical screening of the Bacillus maritimus isolates have showed varieties of bioactive groups in addition to total phenolic compounds, flavonoids, tannic acid, carbohydrates, sulfated polysaccharides, total proteins and lipids. This study highlighted also that the Bacillus maritimus isolate could also produce novel secondary metabolites. The current study report for the first time the Bacillus maritimus in Egypt. Further studies are needed to isolate and characterize more bioactive strains from Egyptian Fishes that could possibly act as novel bioactive compounds source of medical and agricultures importance

Marine microalgae and their industrial biotechnological applications: A review

Background: For use in specialized programs in the food, pharmaceutical, nutraceutical, cosmetic, and animal feed sectors, micro-algal biomass has been generated industrially. They can be grown in closed buildings, such as photobioreactors, or open structures. The utilization of biomass from microalgae for energy production is another crucial topic. Because of the world’s diminishing petroleum sources and the greenhouse gas emissions from gasoline lines, it is now obvious that fuels generated from petroleum are not sustainable. Results: Microalgae can produce a variety of unique, sustainable biofuels. These include biodiesel made from trans-esterification of microalgal lipids, bioethanol from fermentation of carbohydrates, methane created by anaerobic digestion of algal biomass, and biohydrogen produced by photobiological processes. The idea of using microalgae as a fuel source is not entirely novel. Conclusion: This analysis emphasizes the significance of recent and noteworthy advancements in the industrial usage of microalgae, with an emphasis on their biotechnological applications

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Abstract Background: The liver and kidney inflammation due to bacterial infection is one of the most common pathological problems leading to tissue damage or disease. In many liver and kidney disorders, which represent serious global health burden with a high economic cost, oxidative stress-related inflammation and apoptosis are important pathogenic components, finally resulting in acute liver and/or kidney failure. Erythropoietin and its analogues are well known to influence the interaction between apoptosis and inflammation in liver and kidney. Objective: The aim of the present study is to investigate and clarify the effect of Galaxaura oblongata (G. oblongata) red algae on lipopolysaccharides (LPS)-induced acute liver and kidney injury of mice with endotoxemia and associated molecular mechanism from inflammation, apoptosis and oxidative stress levels. Results: The current study cleared out that treatment of rats with the G. oblongata extract prior to LPS injection significantly lowered serum cytokines, including NF-κB, MPO and LPO, and improved liver apoptosis through suppressing protein tyrosine kinase signaling pathway, and that may be due to antibacterial activity as well antioxidant capacity of G. oblongata extract. Conclusion: The present study was cleared out the possibility of administration of G. oblongata red algae as a multi products source for biotechnological, medical, nutraceutical and pharmaceutical applications due to highly antioxidant and anti-inflammatory capacities even although more investigations are required for separating, purifying and characterizing these bioactive compounds.</jats:p