Measured reduction in Alfv\'en wave energy propagating through longitudinal gradients scaled to match solar coronal holes

We have explored the effectiveness of a longitudinal gradient in Alfv\'en speed in reducing the energy of propagating Alfv\'en waves under conditions scaled to match solar coronal holes. The experiments were conducted in the Large Plasma Device at the University of California, Los Angeles. Our results show that the energy of the transmitted Alfv\'en wave decreases as the inhomogeneity parameter, $\lambda/L_{\rm A}$, increases. Here, $\lambda$ is the wavelength of the Alfv\'en wave and $L_{\rm A}$ is the scale length of Alfv\'en speed gradient. For gradients similar to those in coronal holes, the waves are observed to lose a factor of $\approx 5$ more energy than they do when propagating through a uniform plasma without a gradient. We have carried out further experiments and analyses to constrain the cause of wave energy reduction in the gradient. The loss of Alfv\'en wave energy from mode coupling is unlikely, as we have not detected any other modes. Contrary to theoretical expectations, the reduction in the energy of the transmitted wave is not accompanied by a detectable reflected wave. Nonlinear effects are ruled out as the amplitude of the initial wave is too small and the wave frequency well below the ion cyclotron frequency. Since the total energy must be conserved, it is possible that the lost wave energy is being deposited in the plasma. Further studies are needed to explore where the energy is going

Cure after re-resection of colorectal liver metastases in a 28 year old woman. A case report

Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenLiver resection is the only well documented curative treatment for colorectal liver metastases but without surgery survival is dismal. Liver resections can be done for re-metastatic colorectal cancers if the tumors are localized in the liver. The first case of re-resection of colorectal liver metastases in Iceland is presented.Lífshorfur sjúklinga sem greinast með lifrarmeinvörp frá ristilkrabbameini eru slæmar og án meðferðar eru flestir dánir innan árs (1,2). Lifrarúrnám er eina læknandi meðferðin (3). Aðgerðinni má beita við endurtekin meinvörp (4,5). Lýst er tilfelli af endurteknu lifrarhöggi hér á landi

Forecasting Stock Time-Series using Data Approximation and Pattern Sequence Similarity

Time series analysis is the process of building a model using statistical techniques to represent characteristics of time series data. Processing and forecasting huge time series data is a challenging task. This paper presents Approximation and Prediction of Stock Time-series data (APST), which is a two step approach to predict the direction of change of stock price indices. First, performs data approximation by using the technique called Multilevel Segment Mean (MSM). In second phase, prediction is performed for the approximated data using Euclidian distance and Nearest-Neighbour technique. The computational cost of data approximation is O(n ni) and computational cost of prediction task is O(m |NN|). Thus, the accuracy and the time required for prediction in the proposed method is comparatively efficient than the existing Label Based Forecasting (LBF) method [1].Comment: 11 page

Large Eddy Simulation of combustion instabilities in a lean partially premixed swirled flame

This paper investigates one issue related to Large Eddy Simulations (LES) of self- excited combustion instabilities in gas-fueled swirled burners: the effects of incom- plete mixing between the gas injection and the combustion chamber. For simplicity reasons, many LES assume perfect premixing of the gases entering the combustion chamber. In practice this is rarely the case and this study addresses the question by comparing LES assuming perfect premixing and LES where the fuel jets are resolved and fuel/air mixing is explicitely computed. This is done for the Preccin- sta swirled burner which has been carefully studied experimentally at DLR. All previous LES studies of Preccinsta have assumed perfect premixing and this work demonstrates that this assumption is reasonable for stable flows but is not accept- able to predict self-excited unstable cases. This is shown by comparing LES and experimental fields in terms of mean and RMS fields of temperature, species and velocities as well as mixture fraction pdfs and unsteady activity for two regimes: a stable one at equivalence ratio 0.83 and an unstable one at 0.7

Medical students’ perception of their educational environment during foundation course

Background: Learning environment is how students perceive the climate of an institution. The strength and weakness of learning environment should be identified to help change, adjust and manage training programs with objectives for improving learning quality. Dundee Ready Education Environment Measure (DREEM) is a validated tool designed to measure educational environment specifically for medical schools and other health profession institutions. This tool has been used in 20 countries, including Nepal. The aim of this study was to determine the perception of medical students of Foundation Course toward their learning environment using this tool.Methods: The study was conducted among the medical students attending Foundation Course in School of Medicine at Patan Academy of Health Sciences in Nepal using the DREEM tool.Results: Total mean of DREEM score was 150.51 and that of subscales for Students' Perception of Learning (SPL), Students' Perception of Teachers (SPT), Students' Academic Self-Perception (SASP), Students' Perception of Atmosphere (SPOA) and Students' Social Self-Perception (SSSP) were 36.96/48, 34.01/44, 23.96/32, 36.03/48 and 19.55/28 respectively. In item scores, students scored more than 3 for 29 items, between 2 and 3 for 20 items and only 1 item received less than 2 score indicating an issue requiring attention on overemphasis of factual learning during the course.Conclusions: Students have a positive perception about their educational environment. Their perception is a valuable resource for institutional curriculum planners to make appropriate changes to enhance student learning. It is important to get feedbacks from students on how they are experiencing their learning environment

Credibility of Various Indices of Sacrum in Identification of Sex of Sacrum

Background: Determination of sex from skeletal remains is of paramount importance for Forensic Experts for identification of the deceased. The task becomes more difficult when only a single bone is available. Though most bones exhibit clear cut sexual variation in morphology but to determine sex with 100% accuracy, one has to use metric measurements to study various indices. These indices exhibit significant variation in range according ethnicity & geographic location, hence is suggested to arrive at Demarking Point (D.P.) for these parameters which greatly help in sexing of a bone. Sacrum has been considered amongst ideal bones to determine sex of individual because of its functional morphological variation in both sexes by virtue of its contribution to pelvis. Numerous indices have been reported to determine sex of sacra but of it none have proved to effectively & singularly differentiate sex. Hence is advised to not rely on a single index but use maximum possible indices to determine sex of sacrum. Also to be taken in consideration is fact that values of these indices so is their D.P. varies according to geographical location. Hence studies such as this are carried out to calculate anthrometric data regarding various measurements & indices for a particular region. Method: 150 sacra of known sex from Tamil Nadu of South India were studied for metrical parameters for determination of sex. Efforts were made to find Demarking point for each parameter and then compared with similar studies. Results: It was evident from present study that sacral index is the most important parameter as far as the sex determination of sacrum is concerned as it could singularly identify 56% male and 78% female bones. Sacral index for population under study was observed to be 99.21 for males and 119.94 for females. Conclusion: The present study highlight importance of certain parameters like sacral index while also demonstrating insignificance other parameters, but basic fact remains that as far as the sex determination of sacrum is concerned no single parameter could identify sex in 100% of the bones and hence, it can be concluded that for sex determination of the sacrum with 100% accuracy is possible only when maximum number of parameters are taken into consideration

Evaluation of Awareness of Knowledge, Attitude and Practices of Nursing Students on Monitoring and Reporting of Adverse Drug Reactions in a Tertiary Care Hospital

Abstract: To assess the Knowledge, Attitude and Practices of nursing students on monitoring and reporting of adverse drug reactions in a tertiary care hospital. This questionnaire based study was conducted in a tertiary care hospital on 85 Prefinal and final year nursing students. The study instrument was a pre designed questionnaire which included the Knowledge of the ADRs reporting, the attitudes towards the reporting, and the factors which could hinder the reporting. The students were given an educative and interactive session for clearance of their understanding about Pharmacovigilance. The post-session questionnaire was also completed to assess their understanding. A total of 85 students participated. The median knowledge, attitude scores before the intervention were 42.5%, 46.6% respectively. After the intervention the scores increased significantly to 89.4%, 98.8% respectively

Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation

Tumor undergo uncontrolled, excessive proliferation leads to hypoxic microenvironment. To fulfill their demand for nutrient, and oxygen, tumor angiogenesis is required. Endothelial progenitor cells (EPCs) have been known to the main source of angiogenesis because of their potential to differentiation into endothelial cells. Therefore, understanding the mechanism of EPC-mediated angiogenesis in hypoxia is critical for development of cancer therapy. Recently, mitochondrial dynamics has emerged as a critical mechanism for cellular function and differentiation under hypoxic conditions. However, the role of mitochondrial dynamics in hypoxia-induced angiogenesis remains to be elucidated. In this study, we demonstrated that hypoxia-induced mitochondrial fission accelerates EPCs bioactivities. We first investigated the effect of hypoxia on EPC-mediated angiogenesis. Cell migration, invasion, and tube formation was significantly increased under hypoxic conditions; expression of EPC surface markers was unchanged. And mitochondrial fission was induced by hypoxia time-dependent manner. We found that hypoxia-induced mitochondrial fission was triggered by dynamin-related protein Drp1, specifically, phosphorylated DRP1 at Ser637, a suppression marker for mitochondrial fission, was impaired in hypoxia time-dependent manner. To confirm the role of DRP1 in EPC-mediated angiogenesis, we analyzed cell bioactivities using Mdivi-1, a selective DRP1 inhibitor, and DRP1 siRNA. DRP1 silencing or Mdivi-1 treatment dramatically reduced cell migration, invasion, and tube formation in EPCs, but the expression of EPC surface markers was unchanged. In conclusion, we uncovered a novel role of mitochondrial fission in hypoxia-induced angiogenesis. Therefore, we suggest that specific modulation of DRP1-mediated mitochondrial dynamics may be a potential therapeutic strategy in EPC-mediated tumor angiogenesis