Self-reported Evaluation of Psychosocial Effects of Fluorosis among Inhabitants Living in a Rural Fluorosis Epidemic Area in China: Psychosocial Effects of Dental Fluorosis

Objective: The purpose of this study was to investigate the psychosocial effects of fluorosis on the patients in the fluorosis epidemic area. Methods: In the rural fluorosis epidemic areas in Hebei province of China, 416 inhabitants were randomly selected to be examined using Dean’s Index (DI). Surface Index of Fluorosis (TSIF) was used in 178 recruited participants who were also involved in a psychosocial questionnaire investigation. Demographic information and six five-point subscales about “Attitude to Teeth”, “Index of Well-Being”, “Index of General Affect”, “Interaction Anxiousness Scale” (IAS), “Self-Esteem Scale” (SES) and “Impact on Behavior” were included in the questionnaire. SPSS12.0 software was used to analyze the data

ReSimAD: Zero-Shot 3D Domain Transfer for Autonomous Driving with Source Reconstruction and Target Simulation

Domain shifts such as sensor type changes and geographical situation variations are prevalent in Autonomous Driving (AD), which poses a challenge since AD model relying on the previous-domain knowledge can be hardly directly deployed to a new domain without additional costs. In this paper, we provide a new perspective and approach of alleviating the domain shifts, by proposing a Reconstruction-Simulation-Perception (ReSimAD) scheme. Specifically, the implicit reconstruction process is based on the knowledge from the previous old domain, aiming to convert the domain-related knowledge into domain-invariant representations, e.g., 3D scene-level meshes. Besides, the point clouds simulation process of multiple new domains is conditioned on the above reconstructed 3D meshes, where the target-domain-like simulation samples can be obtained, thus reducing the cost of collecting and annotating new-domain data for the subsequent perception process. For experiments, we consider different cross-domain situations such as Waymo-to-KITTI, Waymo-to-nuScenes, Waymo-to-ONCE, etc, to verify the zero-shot target-domain perception using ReSimAD. Results demonstrate that our method is beneficial to boost the domain generalization ability, even promising for 3D pre-training.Comment: Code and simulated points are available at https://github.com/PJLab-ADG/3DTrans#resima

Decreased CD8+CD28+/CD8+CD28– T cell ratio can sensitively predict poor outcome for patients with complicated Crohn disease

Crohn disease (CD) with complications such as penetrating, stricturing, and perianal disease is called complicated CD. The aim of this study is to test the efficiency with which the CD8+CD28+/CD8+CD28– cell balance can predict a subsequent active stage in patients with newly diagnosed complicated CD. Seventeen patients with complicated CD and 48 CD patients with no complications were enrolled. Blood CD8+ T cells were tested from all of the 65 newly diagnosed CD patients upon enrollment. The potential risk factors were compared between the 2 groups. A 30-week follow-up was performed, and the efficiency of the CD8+ cell balance at predicting active CD was analyzed using receiver- operating characteristic curves. The cumulative remission lasting rates (CRLRs) were analyzed using the Kaplan–Meier method. Compared with the control CD group, patients with complicated CD were predominantly male and younger in age; they also had lower body mass indices (BMIs), higher Crohn disease activity indices (CDAIs), higher immunosuppressant and steroid prescription rates, and significantly higher surgical rates. The CD8+CD28+/CD8+CD28– balance was associated with BMI, CDAI, steroids, and surgery. The CD8+CD28+/CD8+CD28– ratios were significantly lower at week 0 and on the 6th, 22nd, and 30th week during follow- up with a shorter lasting time of remission for the complicated CD patients. The CD8+CD28+/CD8+CD28– ratio could accurately predict the active stage for the patients with complicated CD, and the highest sensitivity (89.2%) and specificity (85.3%) were found when the ratio was 1.03. Treatment with steroids and surgery, along with a significantly lower CD8+CD28+/CD8+CD28– ratio and lower CRLRs, was closely related to a worse outcome for the patients with complicated CD. Patients requiring steroids and surgery experience more severe disease activity and thus a disequilibrated immunological balance, which could be the main reason for a decreased CD8+CD28+/CD8+CD28– ratio. This ratio can sensitively predict the active stage for patients with complicated CD, and more care should be taken when this ratio is <1.03

Does hysteroscopy worsen prognosis in women with type II endometrial carcinoma?

Prior studies evaluating the impact of hysteroscopy on outcomes in endometrial cancer have predominantly evaluated type I tumors. We sought to evaluate whether hysteroscopy worsens prognosis in type II endometrial cancer