The Role of Mutual Funds and Non- Banking Financial Companies in Corporate Governance in Pakistan

This paper advances the argument that institutional investors, particularly mutual funds can play a vital role in enhancing corporate governance in emerging economies. Accordingly, regulatory framework need to be structured in a manner that would encourage the growth of the mutual fund industry and enable it to play a proactive role in corporate governance. The paper reviews and evaluates the regulation of mutual funds in Pakistan in the light of the above propositions. The Role of Mutual Funds and Non-Banking Financial Companies in Corporate Governance in Pakistan.Corporate governance, mutual fund, Non-Banking Financial Companies, Pakistan

Value management: An effective innovation management tool for strategic management of technology in the services sector - Case of a VTI

The concept of Strategic technology management (STM) places technology in a strategic context. STM did not emerge as a distinct area of managerial and academic interests until late 1980s. The key managers may initiate efforts to gain access to newer technologies, but the question is whether the approach they adopt is strategic or a series of ad hoc decisions [Quinn, 1988]. Value Management (VM) has assumed an important role in providing leadership and strategic growth to technology firms. Historically VM emphasized use of alternatives to reduce cost, promote innovation and enhance the performance of products. VM has moved beyond manufacturing and can be applied for strategic decision making in the services sector. It is envisaged the VM can be an effective tool for STM. It should help in generating creative ideas on the most appropriate technologies, examination of alternatives, evaluating the alternatives and developing a strategy. A study conducted by the author in the East, revealed that the performance of firms is influenced by the type of strategies developed during the VM process. This result provided the motivation to explore if such strategies are relevant to the managers of the "services" sector and if their performance too is influenced by these adoptions. There is dearth of similar studies in the literature. More importantly, in this age of technology, there is a dire need for management to understand and implement ideas not perceived before. The results could contribute to the literature/management in developing a set of VM strategies which could be termed as "global" and applied to any sector and those termed as "unique" which are specific to firm/service sector. In terms of the services sector, the nearest similarity to the technology intensive firms appear to be the vocational and technical institutions (VTI). The big study sought to identify and analyse the level of awareness of participants on strategy issues and the perception of departments (including those in the Ministries) about STM (and the inherent VM). This paper attempts to present the results on that part of the study which deals with the relationship between the type of the managers/management (gender, qualification, age etc) and the application of developed strategies. The participants included the staff and heads of departments at a technical college from an oil rich ASEAN country, the senior management at the college and the policy makers at the Department of Technical Education (DTE). The strategy and management data was desired from all the three groups. Data was collected through a questionnaire and analyzed using statistical techniques. A pilot-study helped to refine the questionnaire before it was administered. The study sets the tone to open up discussions and research interest towards applying VM tools in the strategic management of technology in the education sector in a rapidly growing digital world. The type of managers/management revealed as part of this study has implications to the senior planners in the education sector in keeping pace with the technology age by providing valuable inputs to innovate, discover, evaluate and develop strategies to provide value to the stakeholders, decision makers and technology lecturers

Length-weight relationships of 13 fish species from Pahang River, Temerloh district, Pahang, Malaysia

Length–weight relationships (LWRs) are described for 13 fish species from Pahang River, Temerloh district, Pahang, Malaysia. The river serves as a main water body for freshwater aquaculture in the country and also supplies various fishes for local consumption. This is the first record of LWRs for nine fish species and new maximum lengths for three species in fishbase

WHO Parents Skills Training (PST) programme for children with developmental disorders and delays delivered by Family Volunteers in rural Pakistan: study protocol for effectiveness implementation hybrid cluster randomized controlled trial

Development disorders and delays are recognised as a public health priority and included in the WHO mental health gap action programme (mhGAP). Parents Skills Training (PST) is recommended as a key intervention for such conditions under the WHO mhGAP intervention guide. However, sustainable and scalable delivery of such evidence based interventions remains a challenge. This study aims to evaluate the effectiveness and scaled-up implementation of locally adapted WHO PST programme delivered by family volunteers in rural Pakistan. The study is a two arm single-blind effectiveness implementation-hybrid cluster randomised controlled trial. WHO PST programme will be delivered by 'family volunteers' to the caregivers of children with developmental disorders and delays in community-based settings. The intervention consists of the WHO PST along with the WHO mhGAP intervention for developmental disorders adapted for delivery using the android application on a tablet device. A total of 540 parent-child dyads will be recruited from 30 clusters. The primary outcome is child's functioning, measured by WHO Disability Assessment Schedule - child version (WHODAS-Child) at 6 months post intervention. Secondary outcomes include children's social communication and joint engagement with their caregiver, social emotional well-being, parental health related quality of life, family empowerment and stigmatizing experiences. Mixed method will be used to collect data on implementation outcomes. Trial has been retrospectively registered at ClinicalTrials.gov (NCT02792894). This study addresses implementation challenges in the real world by incorporating evidence-based intervention strategies with social, technological and business innovations. If proven effective, the study will contribute to scaled-up implementation of evidence-based packages for public mental health in low resource settings. Registered with ClinicalTrials.gov as Family Networks (FaNs) for Children with Developmental Disorders and Delays. Identifier: NCT02792894 Registered on 6 July 2016

The effectiveness and cost-effectiveness of the peer-delivered Thinking Healthy Programme for perinatal depression in Pakistan and India: the SHARE study protocol for randomised controlled trials.

BACKGROUND: Rates of perinatal depression (antenatal and postnatal depression) in South Asia are among the highest in the world. The delivery of effective psychological treatments for perinatal depression through existing health systems is a challenge due to a lack of human resources. This paper reports on a trial protocol that aims to evaluate the effectiveness and cost-effectiveness of the Thinking Healthy Programme delivered by peers (Thinking Healthy Programme Peer-delivered; THPP), for women with moderate to severe perinatal depression in rural and urban settings in Pakistan and India. METHODS/DESIGN: THPP is evaluated with two randomised controlled trials: a cluster trial in Rawalpindi, Pakistan, and an individually randomised trial in Goa, India. Trial participants are pregnant women who are registered with the lady health workers in the study area in Pakistan and pregnant women attending outpatient antenatal clinics in India. They will be screened using the patient health questionnaire-9 (PHQ-9) for depression symptoms and will be eligible if their PHQ-9 is equal to or greater than 10 (PHQ-9 ≥ 10). The sample size will be 560 and 280 women in Pakistan and India, respectively. Women in the intervention arm (THPP) will be offered ten individual and four group sessions (Pakistan) or 6-14 individual sessions (India) delivered by a peer (defined as a mother from the same community who is trained and supervised in delivering the intervention). Women in the control arm (enhanced usual care) will receive health care as usual, enhanced by providing the gynaecologist or primary-health facilities with adapted WHO mhGAP guidelines for depression treatment, and providing the woman with her diagnosis and information on how to seek help for herself. The primary outcomes are remission and severity of depression symptoms at the 6-month postnatal follow-up. Secondary outcomes include remission and severity of depression symptoms at the 3-month postnatal follow-up, functional disability, perceived social support, breastfeeding rates, infant height and weight, and costs of health care at the 3- and 6-month postnatal follow-ups. The primary analysis will be intention-to-treat. DISCUSSION: The trials have the potential to strengthen the evidence on the effectiveness and cost-effectiveness of an evidence-based psychological treatment recommended by the World Health Organisation and delivered by peers for perinatal depression. The trials have the unique opportunity to overcome the shortage of human resources in global mental health and may advance our understanding about the use of peers who work in partnership with the existing health systems in low-resource settings. TRIAL REGISTRATION: Pakistan Trial: ClinicalTrials.gov Identifier: NCT02111915 (9 April 2014) India Trial: ClinicalTrials.gov Identifier: NCT02104232 (1 April 2014)

Development of a physical map of the soybean pathogen Fusarium virguliforme based on synteny with Fusarium graminearum genomic DNA

<p>Abstract</p> <p>Background</p> <p>Reference genome sequences within the major taxa can be used to assist the development of genomic tools for related organisms. A major constraint in the use of these sequenced and annotated genomes is divergent evolution. Divergence of organisms from a common ancestor may have occurred millions of years ago, leading to apparently un-related and un-syntenic genomes when sequence alignment is attempted.</p> <p>Results</p> <p>A series of programs were written to prepare 36 Mbp of <it>Fusarium graminearum </it>sequence in 19 scaffolds as a reference genome. Exactly 4,152 Bacterial artificial chromosome (BAC) end sequences from 2,178 large-insert <it>Fusarium virguliforme </it>clones were tested against this sequence. A total of 94 maps of <it>F. graminearum </it>sequence scaffolds, annotated exonic fragments and associated <it>F. virguliforme </it>sequences resulted.</p> <p>Conclusion</p> <p>Developed here was a technique that allowed the comparison of genomes based on small, 15 bp regions of shared identity. The main power of this method lay in its ability to align <it>diverged </it>sequences. This work is unique in that discontinuous sequences were used for the analysis and information not readily apparent, such as match direction, are presented. The 94 maps and JAVA programs are freely available on the Web and by request.</p

Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1.

Glucose deprivation, hypoxia and acidosis are characteristic features of the central core of most solid tumours. Myofibroblasts are stromal cells present in many such solid tumours, including those of the colon, and are known to be involved in all stages of tumour progression. HMGB1 is a nuclear protein with an important role in nucleosome stabilisation and gene transcription; it is also released from immune cells and is involved in the inflammatory process. We report that the microenvironmental condition of glucose deprivation is responsible for the active release of HMGB1 from various types of cancer cell lines (HT-29, MCF-7 and A549) under normoxic conditions. Recombinant HMGB1 (10 ng/ml) triggered proliferation in myofibroblast cells via activation of PI3K and MEK1/2. Conditioned medium collected from glucose-deprived HT-29 colon cancer cells stimulated the migration and invasion of colonic myofibroblasts, and these processes were significantly inhibited by immunoneutralising antibodies to HMGB1, RAGE and TLR4, together with specific inhibitors of PI3K and MEK1/2. Our data suggest that HMGB1 released from cancer cells under glucose deprivation is involved in stimulating colonic myofibroblast migration and invasion and that this occurs through the activation of RAGE and TLR4, resulting in the activation of the MAPK and PI3K signalling pathways. Thus, HMGB1 might be released by cancer cells in areas of low glucose in solid tumours with the resulting activation of myofibroblasts and is a potential therapeutic target to inhibit solid tumour growth