Processes of urban design preservation and renewal in Tel- Aviv; HaBima Square

Ponencia presentada a Session 7: Redes sociofísicas en el planeamiento urbano / Urban social and physical network

Communications

Various communications concerning previous topics covered in Performance Practice Revie

Communications

Various communications concerning previous topics covered in Performance Practice Revie

Permutabilidade entre o disco de Plácido e o sistema Scheimpflug: análise quantitativa e qualitativa

PURPOSE: Many systems try to replace Placido disc-based topographers, such as those based in Scheimpflug principles. The purpose of this study is to check if they are interchangeable. METHODS: Quantitative analysis evaluated data obtained from EyeSys and Pentacam, i.e. simulated keratometric values, in addition to flattest and steepest keratometric values. Sixty-three maps from each device (EyeSys scale=0.5 D; Pentacam scale= 0.25 D) were used for the comparison. Qualitative analysis selected 10 EyeSys and 15 Pentacam topographies used in the quantitative evaluation. Aspheric, keratoconus suspects (KS) and established keratoconus corneas were included. Four groups (children [CH], non-physicians adults [AD], residents in ophthalmology [OP] and refractive surgeons [RS]) were asked to match the topographies belonging to the same eye. RESULTS: Analysis showed that the parameters are correlated; however they are not clinically similar. In the qualitative analysis, the percent of correct matches increased when KS was removed. CH group was statistically different from every group in these comparisons. When only KS was considered, CH vs. OP, CH vs. RS and AD vs. RS remained statistically different. AD vs. OP showed no relevant difference in any comparison. CONCLUSIONS: The systems are not fully interchangeable, yet they are correlated. Practitioners who are adapting to Pentacam should use the 0.25 D scale maps and transform formulas that use EyeSys parameters. Only with persistent training may the topographies be properly matched; KS corneas are more difficult to be correctly paired.OBJETIVO: Muitos sistemas tentam substituir os topógrafos baseados no disco de Plácido, como aqueles baseados nos princípios de Scheimpflug. O objetivo deste estudo é verificar se eles são intercambiáveis. MÉTODOS: A análise quantitativa avaliou dados obtidos através do EyeSys e do Pentacam, os valores de ceratometria simulada, além dos menores e maiores valores ceratométricos observados. Sessenta e três mapas de cada dispositivo (escala do EyeSys=0,5D; escala do Pentacam=0,25D) foram utilizados na comparação. Para a análise qualitativa, foram selecionadas 10 topografias do Pentacam e 15 do EyeSys. Córneas asféricas, suspeitas de ceratocone (KS) e com diagnóstico de ceratocone foram incluídas. Quatro grupos (crianças [CH], os adultos não-médicos [AD], residentes em oftalmologia [OP] e cirurgiões refrativos [RS]) foram convidados a corresponder as topografias pertencentes ao mesmo olho. RESULTADOS: As análises mostraram que os parâmetros estão correlacionados, no entanto, não são clinicamente similares. Na análise qualitativa, o porcentual de acertos aumentou quando KS foram removidas. O grupo CH foi estatisticamente diferente de qualquer outro grupo, nestas comparações. Quando somente KS foram consideradas, CH vs. OP, CH vs. RS e AD vs. RS manteve-se estatisticamente diferente. AD vs. OP não mostrou nenhuma diferença relevante em qualquer comparação. CONCLUSÕES: Os sistemas não são totalmente intercambiáveis, porém são correlacionados. Os profissionais que estão se adaptando ao Pentacam devem utilizar os mapas de escala 0,25 D e transformar fórmulas que usem parâmetros do EyeSys. Somente com treinamento persistente as topografias podem ser devidamente relacionadas; córneas KS são mais difíceis de ser pareadas corretamente.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Ophthalmology DepartmentUNIFESP, EPM, Ophthalmology DepartmentSciEL

Brillouin optical correlation domain analysis in composite material beams

Structural health monitoring is a critical requirement in many composites. Numerous monitoring strategies rely on measurements of temperature or strain (or both), however these are often restricted to point-sensing or to the coverage of small areas. Spatially-continuous data can be obtained with optical fiber sensors. In this work, we report high-resolution distributed Brillouin sensing over standard fibers that are embedded in composite structures. A phase-coded, Brillouin optical correlation domain analysis (B-OCDA) protocol was employed, with spatial resolution of 2 cm and sensitivity of 1 °K or 20 micro-strain. A portable measurement setup was designed and assembled on the premises of a composite structures manufacturer. The setup was successfully utilized in several structural health monitoring scenarios: (a) monitoring the production and curing of a composite beam over 60 h; (b) estimating the stiffness and Young’s modulus of a composite beam; and (c) distributed strain measurements across the surfaces of a model wing of an unmanned aerial vehicle. The measurements are supported by the predictions of structural analysis calculations. The results illustrate the potential added values of high-resolution, distributed Brillouin sensing in the structural health monitoring of composites

Meter in Music, 1600-1800 By George Houle

Silbiger discusses and reviews Houle\u27s 1987 book

Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

ephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair intermediates that damage healthy tissues. We have shown that the alkyladenine DNA glycosylase, Aag (a.k.a. Mpg), an enzyme that initiates BER, mediates alkylation-induced whole-animal lethality and cytotoxicity in the pancreas, spleen, retina, and cerebellum, but not in the kidney. Cytotoxicity in both wild-type and Aag-transgenic mice (AagTg) was abrogated in the absence of Poly(ADP-ribose) polymerase-1 (Parp1). Here we report that Parp1-deficient mice expressing increased Aag (AagTg/Parp1-/-) develop sex-dependent kidney failure upon exposure to the alkylating agent, methyl methanesulfonate (MMS), and suffer increased whole-animal lethality compared to AagTg and wild-type mice. Macroscopic, histological, electron microscopic and immunohistochemical analyses revealed morphological kidney damage including dilated tubules, proteinaceous casts, vacuolation, collapse of the glomerular tuft, and deterioration of podocyte structure. Moreover, mice exhibited clinical signs of kidney disease indicating functional damage, including elevated blood nitrogen urea and creatinine, hypoproteinemia and proteinuria. Pharmacological Parp inhibition in AagTg mice also resulted in sensitivity to MMS-induced nephrotoxicity. These findings provide in vivo evidence that Parp1 modulates Aag-dependent MMS-induced nephrotoxicity in a sex-dependent manner and highlight the critical roles that Aag-initiated BER and Parp1 may play in determining the side-effects of chemotherapeutic alkylating agents.United States. National Institutes of Health (R01- CA075576)United States. National Institutes of Health (R01-CA055042)United States. National Institutes of Health (R01-CA149261)United States. National Institutes of Health (AGSS- 3046-12)United States. National Institutes of Health (P30-ES02109)United States. National Institutes of Health (P30-CA014051

INTERSpECIFIC vARIATION IN ANEMONE ShRIMp dISTRIBUTION ANd hOST SELECTION IN ThE FLORIdA KEyS (USA): IMpLICATIONS FOR MARINE CONSERvATION

Host and symbiont abundances often depend on the degree of host specificity and differences in costs and benefits of these associations. In this study, we investigated the distribution of anemone shrimps and their hosts along with the shrimps' host selection behavior to evaluate the degree of host specificity in a nearshore benthic community undergoing rapid environmental change. We compared the distribution of two shrimp species, Periclimenes pedersoni Chace, 1958, and Periclimenes yucatanicus (Ives, 1891), with their three anemone hosts, Condylactis gigantea (Weinland, 1860), Stichodactyla helianthus (Ellis, 1767), and Bartholomea annulata (Lesueur, 1817). The proportion of host anemones occupied by each shrimp species was significantly non-random considering abundance of each species per location and significantly different from a previous study conducted 18 yrs earlier. This was due to a decline in S. helianthus abundance. Periclimenes yucatanicus abundance was correlated with C. gigantea abundance, but P. pedersoni abundance was correlated with B. annulata abundance and all anemone species combined. A dichotomous choice test between C. gigantea and B. annulata revealed that P. yucatanicus selected C. gigantea regardless of its original host species. However, P. pedersoni selected its original host species. These results suggest that P. yucatanicus retains a strong host specificity for C. gigantea, whereas P. pedersoni appears to show no particular host specificity. Species with strong host specificity, such as P. yucatanicus, may be less likely to switch host species, and therefore, may be more susceptible to a decline in host abundance