24,133 research outputs found
Superconductivity and magnetism on flux grown single crystals of NiBi3
We present resistivity, magnetization and specific heat measurements on flux
grown single crystals of NiBi3. We find typical behavior of a type-II
superconductor, with, however, a sizable magnetic signal in the superconducting
phase. There is a hysteretic magnetization characteristic of a ferromagnetic
compound. By following the magnetization as a function of temperature, we find
a drop at temperatures corresponding to the Curie temperature of ferromagnetic
amorphous Ni. Thus, we assign the magnetism in NiBi crystals to amorphous
Ni impurities
Discursos de estudantes de ciências sobre as mudanças climáticas na TV
O objetivo deste trabalho foi compreender as relações discursivas que estudantes estabelecem com textos televisivos e com a ciência significada pela TV em sala de aula. Analisamos, com aportes da Análise de Discurso francesa, as respostas escritas por estudantes do ensino médio em uma das atividades de uma unidade de ensino que trabalhou o efeito-leitor da TV quando esta traz como referentes discursos científicos sobre Mudanças Climáticas. Apontamos sentidos construídos por esses estudantes e deslocamentos quanto ao texto televisivo e à ciência significada pela televisão, relacionados a mediações produzidas em aula, como o reconhecimento da não transparência da linguagem televisiva. Percebemos também que, ao ser trabalhada a materialidade discursiva, ocorrem mudanças nos modos de significar os próprios discursos científicos
A practical approach on water quality monitoring based on distributed measurement system and intelligent signal processing
BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single
Aims: To evaluate the efficacy and safety of the treatment of psoriatic arthritis (PsA) patients with tumor necrosis factor (TNF) antagonists in the Rheumatology Department of Hospital de Santa Maria using the BioRePortAP.
Methods: The Portuguese Society of Rheumatology (SPR) developed an electronic medical chart coupled with a database for the follow up of PsA patients, the BioRePortAP, which was launched in May 2009. This evaluation was based on all the PsA patients that were on active treatment with TNF antagonists in September 2009 and were registered in the BioRePortAP. All the previous data on these patients were introduced in BioRePortAP using the prospective paper based follow up protocol that this Department was using since 1999. Only patients with more than 9 months of treatment were analyzed.
Results: Forty-two patients with PsA, actively treated with anti-TNF agents in September 2009, for at least 9 months, were analyzed in BioRePortAP. Twenty-three patients were male (55%) and nineteen were female (45%). The average age of these patients was 49.8±10.9 years old, the average disease duration was of 10.7±5.6 years and the mean duration of biological therapy was of 37.8±27.8 months. For the 81% of patients with peripheral joint disease there was a mean reduction of more than 80% in the swollen and tender joint counts, and almost 50% in the health assessment questionnaire (HAQ) value. In the 19% of the patients with axial involvement the reduction of BASDAI and BASFI was not statistically significative. On top of that, PASI score suffered a reduction of 64%. Fourteen patients (33.3%) had to switch their TNF antagonist treatment. 58.8% of the switches were due to adverse effects and 41.2% due to therapy failure. Regarding the 56 adverse reactions registered, only one was a severe reaction. The remaining adverse reactions were not severe and 67% of them were due to infections.
Discussion: The results of this first report of the use of the BioRePortAP in clinical practice confirm the efficacy and safety of TNF antagonist treatment in PsA. The results shown here elucidate the potential applications of BioRePortAP as a tool for efficacy and safety assessment of PsA patients treated with biotechnological drugs
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