Experimental validation for chatter stability prediction

This research focused on the experimental validation for chatter stability prediction. An optimum machining was aimed to maximize the material removal rate, whilst maintaining a sufficient stability margin to assure the surface quality. High material removal rate in machining produced self-excited vibration or chatter of the cutting tool and the workpiece. This resulted in a poor surface finish and dimensional accuracy, chipping of the cutter teeth, and also may damage the workpiece as well as machining tool. Frequency response function of a single degree freedom flexural was measured and the cutting stiffness of tools were determined in order to be used in predicting chatter stability using semi discretization method. The aluminium 7075 specimens were used in the milling cutting experiment to validate the chatter stability diagram of mill uniform and variable cutters, where a set of spindle speed and depth of cut had tested. The vibration conditions of machining were identified by analysing the vibration signals and FFT spectrum whether it was stable or in a chatter condition. There are good agreement between predicted stability and cutting experiment for the down-milling operation using uniform 4 flute cutting tool. Stable conditions were shown outside the boundary of chatter region. The optimized cutting tool was predicted to suppress chatter. Machining experiment tests showed there were no chatter vibration conditions during machining process until 1.5 mm depth of cut. According to the results of machining experiment, it was proven that the variable tool had more capability to machining without producing chatter vibration as compared to the regular tool

Survivability of entrapped Lactobacillus rhamnosus in liquid- and gel-core alginate beads during storge and simulated gastrointestinal conditions

L. rhamnosus cells were encapsulated in liquid-core (LCBR) and gel-core (GCBR) calcium alginate beads, and cell survivability under storage conditions and simulated gastrointestinal conditions were evaluated, and compared with that of non-encapsulated cells. The average external diameters of both beads (1.37 - 0.25 mm) were non-significantly dierent, and the average thickness of alginate gelled layer in LCBR was of 0.27 - 0.01 mm. The bacteria entrapped into LCBR tended to gather together forming clusters in the bulk of the liquid phase of the bead, whereas the bacteria entrapped into GCBR were compartmentalized in the gelled bead biopolymer matrix. LCBR showed significant lower hardness and chewiness, higher cohesiveness, and comparable springiness values than GCBR. Cells survivability under storage and simulated gastrointestinal conditions was significantly higher in LCBR than in GCBR and for the non-encapsulated free cells

Artistic Strategies for Scenography Training. A Study Case: The course on Scenography at the Universidad de Málaga.

JMER es una revista internacional, de investigación en educación, revisada por pares, publicada mensualmente en inglés por Academic Star Publishing Company, EE. UU. Indexada en: Crossref , ICI Journals Master List / ICI World of Journals, Worldcat, PBN/POL-Index, Ulrich's periodicals, Google Scholar, SSRN, Index Copernicus International. http://www.academicstar.us/journalsshow.asp?ArtID=365&showa=show_subThis paper deals with some training approaches on the course on Scenography taught at the Universidad de Málaga’s Fine Arts School, Spain. The course, included in the Sculpture course of study, aims at exploring the artistic creation process involved in scenography design and caters for some active participation of students to enhance their creativity and research-based artistic and experimental thinking, both formally and conceptually, as defined in Julio Cortázar’s short story book Cronopios and famas. The main course objective is to set up a training time and space where students can research, create and develop new expressive and symbolic alternatives to further design and provide their own scenography proposals. The paper further reviews some theories published on creativity in the artistic arena and on the creation process itself by using Cortázar’s literature as a starting point.Proyecto de investigación competitivo "Estudio y puesta en valor de la docencia de la Escenografía en las universidades españolas mediante un SEES (Scenography Education Expert System) y su implementación con nuevas tecnologías" del Plan Propio de Investigación de la Universidad de Málaga

Accuracy and Survival Outcomes after National Implementation of Sentinel Lymph Node Biopsy in Early Stage Endometrial Cancer

Accuracy; Sentinel lymph node biopsy; Endometrial cancerPrecisión; Biopsia del ganglio linfático centinela; Cáncer de endometrioPrecisió; Biòpsia del gangli limfàtic sentinella; Càncer d'endometriBackground Sentinel lymph node (SLN) biopsy has recently been accepted to evaluate nodal status in endometrial cancer at early stage, which is key to tailoring adjuvant treatments. Our aim was to evaluate the national implementation of SLN biopsy in terms of accuracy to detect nodal disease in a clinical setting and oncologic outcomes according to the volume of nodal disease. Patients and Methods A total of 29 Spanish centers participated in this retrospective, multicenter registry including patients with endometrial adenocarcinoma at preoperative early stage who had undergone SLN biopsy between 2015 and 2021. Each center collected data regarding demographic, clinical, histologic, therapeutic, and survival characteristics. Results A total of 892 patients were enrolled. After the surgery, 12.9% were suprastaged to FIGO 2009 stages III–IV and 108 patients (12.1%) had nodal involvement: 54.6% macrometastasis, 22.2% micrometastases, and 23.1% isolated tumor cells (ITC). Sensitivity of SLN biopsy was 93.7% and false negative rate was 6.2%. After a median follow up of 1.81 years, overall surivial and disease-free survival were significantly lower in patients who had macrometastases when compared with patients with negative nodes, micrometastases or ITC. Conclusions In our nationwide cohort we obtained high sensitivity of SLN biopsy to detect nodal disease. The oncologic outcomes of patients with negative nodes and low-volume disease were similar after tailoring adjuvant treatments. In total, 22% of patients with macrometastasis and 50% of patients with micrometastasis were at low risk of nodal metastasis according to their preoperative risk factors, revealing the importance of SLN biopsy in the surgical management of patients with early stage EC.Open Access Funding provided by Universitat Autonoma de Barcelona

Activation of Wnt/β-catenin signaling in abdominal aortic aneurysm: A potential therapeutic opportunity?

Abdominal aortic aneurysmAneurisma aórtico abdominalAneurisma aòrtic abdominalThis work was supported by Instituto de Salud Carlos III (ISCIII) (No. PI21/01048, PI20/01649), the European Regional Development Fund (ERDF-FEDER, a way to build Europe), Ministerio de Ciencia e Innovación (No. RTI2018-094727-B-100), AGAUR (No. 2017-SGR-00333, 2017-SGR-1807) and Consejo Superior de Investigaciones Científicas (No. 2021AEP073). L. P. is supported by a PFIS contract (ISCIII), C.B–S by a FPU fellowship and A.R.-S. and M.G. were funded by the Miguel Servet Program

Coping styles of relatives of patients admitted to an intensive care unit: A systematic review

[ES] Introducción: Hasta un tercio de los familiares de pacientes críticos desarrollan síntomas de estrés postraumático, además de otras patologías mentales. Conocer la forma en la que las familias afrontan el ingreso y la estancia en la UCI puede ayudarnos a elaborar intervenciones que disminuyan el riesgo de aparición de estos síntomas. Nuestro objetivo fue identificar las estrategias de afrontamiento de las familias de pacientes críticos. Metodología: Revisión sistemática cualitativa de las publicaciones a este respecto, siguiendo las directrices de la declaración PRISMA, realizada entre el 5 y el 15 de abril de 2017 en las bases de datos Web of Science, CINAHL, Pubmed, OpenGrey, y en los repositorios Recolecta, Open Grey y DART-Europe. Para la búsqueda fueron empleados descriptores DeCS Y MeSH. Resultados: Se obtuvieron ocho estudios cuantitativos, nueve estudios cualitativos y uno mixto válidos para nuestro análisis. La estrategia más utilizada es la “resolución de problemas”, mediante el acompañamiento, seguida de la “búsqueda de apoyo”. Estrategias ineficaces como la “rumiación” son las menos utilizadas según los estudios cuantitativos, pero fueron encontradas de forma más clara en los estudios cualitativos. Conclusiones: La estrategia de “resolución de problemas” no se contempla como positiva en sí misma, ya que depende del contexto en el que tiene lugar. El acompañamiento como estrategia de afrontamiento puede manifestar el deseo del familiar de ayudar al paciente, por lo que parece adecuado implementar intervenciones dirigidas a la implicación de los familiares en el cuidado. La evidencia demuestra la necesidad de nueva investigación orientada hacia el desarrollo de instrumentos que posibiliten el estudio del afrontamiento entre los familiares del paciente crítico.[EN] Introduction Up to one-third of the critically ill family members develop post-traumatic stress symptoms, as well as other mental pathologies. Knowing how families cope with the admission in the ICU could help us to design future interventions that may reduce the risk of these symptoms. Our objective was to identify the coping strategies of the critically ill family members. Methodology Systematic Qualitative Review, following the guidelines of the PRISMA statement, done between April 5 and 15, 2017. Web of Science, CINAHL, Pubmed and OpenGrey databases were searched, and the Recolecta, Open Grey and DART-Europe databases. MeSH “adaptation, psychological”, “family” and “intensive care unit” were used as well as other keywords. Results Eight quantitative studies, nine qualitative studies and one mixed study were obtained. The most commonly used strategy was “problem solving”, through “passive presence”, followed by “search for support”. Ineffective strategies such as “rumination” were the least used in quantitative studies, but they appeared clearly in qualitative studies. Conclusions The “problem solving” strategy is not considered as positive in itself, because it depends on the context in which it takes place. “Presence” as a coping strategy might reveal the family´s desire to help the patient. Thus, interventions should be adopted in order to involve family members in patients´ care. Further research should be done on the development of instruments that reflects the particularities of coping strategies among the relatives of the critical patients

Megavejiga fetal. Presentación de un caso clínico

Introducción: La incidencia estimada de la megavejiga entre las semanas 10 y 14 de gestación está entre 1/900 a 1/1800 casos. Esta puede resolverse de forma espontánea en el 40-60% de los casos sin dejar secuelas o ser la manifestación de una patología progresiva obstructiva o un trastorno heterogéneo más complejo. El riesgo de aneuploidía es mayor en el caso de megavejiga moderada, entre 7 y 15 mm. Mediciones mayores se asocian más frecuentemente a causa obstructiva. Presentamos a continuación el caso de una megavejiga fetal, su diagnóstico y finalización. Caso clínico: Paciente de 42 años de raza blanca. Con antecedentes personales de depresión y urticaria colinérgica. Intervenida de cesárea segmentaria transversa en 1991. G5P2C1A1. Essure en 2012. Gestación producida por FIV con transferencia de 2 embriones congelados el día 02/02/2016 (óvulos propios y espermatozoides de la pareja). Gestación única con fecha probable de parto por ecografía el 21/10/2016. Acude a consulta a las 12 semanas para control ecográfico y cribado de cromosomopatías. Se realiza ecografía, observándose megavejiga de 11 mm, riñones hiperecogénicos con pelvis renales dilatadas. Resto de la exploración normal. Resultado de cribado combinado de alto riesgo. Se recomienda estudio de cariotipo fetal y arrays. Acude en la semana 14 para control ecográfico, se observa una megavejiga de 50 mm de diámetro con aumento de la ecogenicidad renal bilateral, dilatación de ambas pelvis renales y líquido amniótico escaso. Se le informa de mal pronóstico. Se presenta a las 15 semanas para la realización de amniocentesis, con el hallazgo de exitus fetal. El estudio anatomopatológico informó megavejiga de probable causa obstructiva, sin otros hallazgos. No se obtuvo cariotipo fetal. Conclusión La enfermedad renal obstructiva es un cuadro que incluye la hidronefrosis, el hidroureter, la megavejiga y la megauretra. La mortalidad debida a alteraciones del tracto urinario es alta, aproximadamente del 60 %. Existen distintas estrategias a seguir: control ecográfico, finalización de la gestación, inducción del parto y cirugía intraútero. La detección de estas alteraciones mediante la ecografía del primer trimestre del embarazo, afianzan la importancia que tiene la realización del ultrasonido en este período del embarazo para el asesoramiento de la pareja en cuanto a que conducta seguir.Introdución: A incidencia estimada da megavexiga entre as semanas 10 e 14 de xestación está entre 1/900 a 1/1800 casos. Esta pode resolverse de forma espontánea no 40-60% dos casos sen deixar secuelas ou ser a manifestación dunha patoloxía progresiva obstrutiva ou un trastorno heteroxéneo máis complexo. O risco de aneuploidía é maior no caso de megavexiga moderada, entre 7 e 15 mm. Medicións maiores asócianse máis frecuentemente a causa obstrutiva. Presentamos a continuación o caso dunha megavexiga fetal, o seu diagnóstico e finalización. Caso clínico: Paciente de 42 anos de raza branca. Con antecedentes persoais de depresión e urticaria colinérxica. Intervida de cesárea segmentaria transversa en 1991. G5 P2 C1A1. Essure en 2012. Xestación producida por FIV con transferencia de 2 embrións conxelados o día 02/02/2016 (óvulos propios e espermatozoides da parella). Xestación única con data probable de parto por ecografía o 21/10/2016. Acode a consulta ás 12 semanas para control ecográfico e rastrexo de cromosomopatías. Realízase ecografía, observándose megavexiga de 11 mm, riles hiperecoxenicos con pelvis renais dilatadas. Resto da exploración normal. Resultado de cribado combinado de alto risco. Recoméndase estudo de cariotipo fetal e arrays. Acode na semana 14 para control ecográfico, obsérvase unha megavexiga de 50 mm de diámetro con aumento da ecoxenicidade renal bilateral, dilatación de ambas as pelvis renais e líquido amniótico escaso. Infórmaselle de mal prognóstico. Preséntase ás 15 semanas para a realización de amniocentese, co achado de exitus fetal. O estudo anatomopatolóxico informou megavexiga de probable causa obstrutiva, sen outros achados. Non se obtivo cariotipo fetal. Conclusión A enfermidade renal  obstrutiva é un cadro que inclúe a  hidronefrose, o  hidroureter, a megavexiga e a  megauretra. A mortalidade debida a alteracións do tracto urinario é alta, aproximadamente do 60 %. Existen distintas estratexias a seguir: control ecográfico, finalización da xestación, indución do parto e cirurxía intraútero. A detección destas alteracións mediante a ecografía do primeiro trimestre do embarazo, afianzan a importancia que ten a realización do ultrasón neste período do embarazo para o asesoramento da parella en canto a que conduta seguir.Comunicación-póster presentada en la 34 Edición Nacional Formación S.E.G.O. celebrada en Oviedo del 12 al 16 de junio de 201

Contribution of Genetic Background, Traditional Risk Factors, and HIV-Related Factors to Coronary Artery Disease Events in HIV-Positive Persons

We show in human immunodeficiency virus-positive persons that the coronary artery disease effect of an unfavorable genetic background is comparable to previous studies in the general population, and comparable in size to traditional risk factors and antiretroviral regimens known to increase cardiovascular ris

Donor Deferral Due to Low Hemoglobin-An Updated Systematic Review.

Blood donors attending a donation session may be deferred from donating blood due to a failure to meet low hemoglobin (Hb) thresholds. This costs the blood donor service and donors valuable time and resources. In addition, donors who are deferred may have more symptoms, and as a direct and/or indirect effect of their experience, return rates of donors deferred for low Hb are reduced, even in repeat donors. It is therefore vital that low Hb deferral (LHD) is minimized. The aim of this updated systematic review is to expand the evidence base for factors which affect a donor's risk of deferral due to low Hb. Studies were identified by searching MEDLINE, Embase, The Cochrane Library, and the WHO International Clinical Trials Registry to March 2019. Demographic data, donor history, hematological/biological factors, and the primary outcome of deferral due to low Hb were extracted. Our primary outcome was deferral due to low Hb. Analyses were descriptive and quantitative; pooled odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by meta-analysis using random-effects models. A total of 116 studies met the inclusion criteria. Meta-analysis showed a significantly greater risk of LHD in females compared with males in studies applying universal Hb thresholds for males and females (OR 14.62 95% CI 12.43-17.19) and in those which used sex-specific thresholds (OR 5.73, 95% CI 4.36-7.53). Higher rates of LHD were also associated with increasing age in men, low body weight, shorter interdonation interval, donors of Hispanic or African descent, higher ambient temperature, donors with low ferritin levels, and donation in a fixed donor center. There was conflicting evidence on the effect of new and repeat donor status, and blood group. This work has strengthened the evidence of the previous review in identifying factors that should be considered in studies of donor deferral and highlighting areas in need of further study, including ABO and Rh blood groups, previous platelet donation, diet, smoking, time of day, and genetic data. These factors may lead to individually tailored donation criteria for safe and efficient donation in the future.This research is supported by core funding from NHS Blood and Transplant, the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Programme (SF, CD), the UK Medical Research Council (MR/L003120/1), the British Heart Foundation (RG/13/13/30194; RG/18/13/33946), and the National Institute for Health Research [Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust]. AB, TB, and KM are funded by the NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). SAR is funded by the National Institute for Health Research [Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust]