Psychopathology of Time in Brain Disease and Schizophrenia

The literature on disturbance of time-sense in brain disease and schizophrenia is reviewed and the subjective experience of altered time-sense reported by 45 out of 350 personally interviewed schizophrenics is analyzed. A review of the literature on the effect of brain damage revealed that some phenomena (déjà vu, reduplication of time, altered tempo to events) were linked with right hemisphere dysfunction, one phenomenon (incorrect sequencing of events) was linked with left anterior brain damage, and others (disrupted “biological clock”, disturbed serise of rate of flow of current or past events) could arise from subcortical as well as focal cortical damage. The sparse literature on disturbed time-sense in schizophrenia suggested that there was a shared psychopathology in this respect with right hemisphere dysfunction. The phenomena encountered in the 45 schizophrenics are described and classified

Trait correlates of success at work

Identifying and developing high potential individuals is fundamental to successful companies and organizations. The present study focuses on the personality traits of high potential individuals. The High Potential Traits Inventory (HPTI) was used to investigate associations between personality traits and measures of career success, in a sample of 383 employed individuals. Results indicate HPTI personality traits relate to subjective and objective measures of success with Conscientiousness being the strongest predictor. The findings of the current study are consistent with previous research on High Flyers. Implications of the current study are discussed, suggesting a clearer operationalization of success is crucial for understanding the underlying mechanisms which lead from personality to potential

AMBAI : an Austronesian language of Irian Jaya, Indonesia

Ambai is a little-known Austronesian language of Irian Jaya, Indonesia. In this work we discuss the more common elements of the phonology, morphology, and clause-level syntax. This work is basically a synchronic description of the Ambai dialect of the Ambai language, but mention is also made of comparative materials in other Austronesian languages , especially in the morphology section, where they shed light on the Ambai data. We have chosen to limit the scope of this work by not discussing any level higher than the simple sentence or what we will call the expanded clause so as to be able to provide some depth of discussion on those areas covered. Chapter 1 places Ambai in its geographical and linguistic setting as a member of Blust's (1978) South Halmahera - West New Guinea group. The theoretical models used are summarized in 1.2 and the scope and purpose of this study in 1.3. In chapter 2 the sound system of Ambai is described in terms of distinctive features, morpheme-structure rules, and phonological processes. An overview of the basic open and closed word classes is given in chapter 3. We also relate Ambai syntax to syntactic universals as put forth by Greenberg (1966) to provide a concise summary of Ambai word order constraints. Chapter 4 discusses the Ambai noun function-based model which describes the NP as phrase employing a consisting of a referential core modified by Association, Qualification, Quantification, and Orientation elements. The final three chapters of this dissertation employ a layered clause model which sees the clause as consisting of a nuclear predicate, core arguments, and peripheral arguments. The clause nucleus is discussed in chapter 5, along with aspect and directionals which are held to be operators over the clause nucleus. The clause core is considered in chapter 6 where the core arguments (i.e. Subject and Object) are defined. Modality, which expresses the intent or ability of the Actor of the predication to perform the action is discussed as the core-level operator. Chapter 7 completes the discussion of the clause by analyzing the peripheral argument~ (e.g. GOAL, LOCATION, etc.) and the operators which obtain to the entire clause (i.e. Status, which includes a realis irrealis continuum; Tense; and Illocutionary Force, which involves declarative, interrqgative, and imperative. Appendix A continues the discussion of the verbal Subject affixes presenting diachronic aspects of the problem. Appendix B presents a narrative text in Ambai and Appendix C provides a basic vocabulary list with the Proto-Austronesian roots from which the words are derived. References cited conclude the dissertation

Incorporation of pollution prevention principles in environmental methods

The principles of pollution prevention (P2) have not been sufficiently incorporated into analytical methods. In this paper, we focus on the needs for and the benefits of incorporating the principles of P2 into environmental analytical methods

Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population

While 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (GWAS) meta-analysis of parent- or self-reported OCS to date (N = 33,943 with complete phenotypic and genome-wide data), combining the results from seven large-scale population-based cohorts from Sweden, the Netherlands, England, and Canada (including six twin cohorts and one cohort of unrelated individuals). We found no genome-wide significant associations at the single-nucleotide polymorphism (SNP) or gene-level, but a polygenic risk score (PRS) based on the OCD GWAS previously published by the Psychiatric Genetics Consortium (PGC-OCD) was significantly associated with OCS (Pfixed = 3.06 × 10−5). Also, one curated gene set (Mootha Gluconeogenesis) reached Bonferroni-corrected significance (Ngenes = 28, Beta = 0.79, SE = 0.16, Pbon = 0.008). Expression of genes in this set is high at sites of insulin mediated glucose disposal. Dysregulated insulin signaling in the etiology of OCS has been suggested by a previous study describing a genetic overlap of OCS with insulin signaling-related traits in children and adolescents. We report a SNP heritability of 4.1% (P = 0.0044) in the meta-analyzed GWAS, and heritability estimates based on the twin cohorts of 33–43%. Genetic correlation analysis showed that OCS were most strongly associated with OCD (rG = 0.72, p = 0.0007) among all tested psychiatric disorders (N = 11). Of all 97 tested phenotypes, 24 showed a significant genetic correlation with OCS, and 66 traits showed concordant directions of effect with OCS and OCD. OCS have a significant polygenic contribution and share genetic risk with diagnosed OCD, supporting the hypothesis that OCD represents the extreme end of widely distributed OCS in the population.</p

Polarized angular distributions of parametric x radiation and vacuum-ultraviolet transition radiation from relativistic electrons

We present quantifiable images of the angular distribution (AO's) of parametric X radiation (PXR) and vacuum-ultraviolet transition radiation (vuv TR) from 230 MeV electrons interacting with a silicon crystal. Both AD's are highly polarized. The vuv TR and optical TR data provide measurements of the beam energy and effective divergence angle. Using these quantities and separately known values of the electronic susceptibility |Xo|, we show that the measured PXR AD is in good agreement with the predictions of single crystal theory. Our analysis suggests a method to measure |Xo| using PXR AD's.Ths work was sponsored in part by DOE SBIR Grant No. DE-FG03-91er80199; NCI SBIR Grant no. 1-R43-CA60207-01 and the Canadian Natural Science and Engineering Research Counci

Quasimonochromatic x-ray source using photoabsorption-edge transition radiation

By designing transition radiators to emit x-rays at the foil material's K-, L-, or M-shell photoabsorption edge, the x-ray spectrum is narrowed. The source is quasimonochromatic, directional, and intense and uses an electron beam whose energy is considerably lower than that needed for synchrotron sources. Depending on the selection of foil material, the radiation can be produced wherever there is a photoabsorption edge. In this paper we report the results of the measurement of the x-ray spectrum from a transition radiator composed of 10 foils of 2-um titanium and exposed to low-current, 90.2-MeV electrons, The measured band of emission was from 3.2 5o 5 keV. In addition, a measurement was performed of the total power from a transition radiator composed of 18 foils of 2.o-um copper exposed to a high-average-current electron beam of 40 uA and at energies of 135, 172, and 200 MeV. The maximum measured power was 4.0 mW. The calculated band of emission was from 4 to 9 keV.National Science Foundation of the Small Business Innovative Research (SBIR) program, Grant no. PHY-8460914; Department of Energy SBIR program, Grant No. DE-FG03-90ER80872; Canadian Natural Science and Engineering Research Council and the Naval Postgraduate SchoolThis investigation was supported by a Special Research Opportunity Grant from the U.S. Office of Naval Research, Department of the Navy and by the Foundation Research Program of the Naval Postgraduate School (Monterey, Ca.)Approved for public release; distribution is unlimited