A Cross-Sectional Study of People with Epilepsy and Neurocysticercosis in Tanzania: Clinical Characteristics and Diagnostic Approaches.

Neurocysticercosis (NCC) is a major cause of epilepsy in regions where pigs are free-ranging and hygiene is poor. Pork production is expected to increase in the next decade in sub-Saharan Africa, hence NCC will likely become more prevalent. In this study, people with epilepsy (PWE, n=212) were followed up 28.6 months after diagnosis of epilepsy. CT scans were performed, and serum and cerebrospinal fluid (CSF) of selected PWE were analysed. We compared the demographic data, clinical characteristics, and associated risk factors of PWE with and without NCC. PWE with NCC (n=35) were more likely to be older at first seizure (24.3 vs. 16.3 years, p=0.097), consumed more pork (97.1% vs. 73.6%, p=0.001), and were more often a member of the Iraqw tribe (94.3% vs. 67.8%, p=0.005) than PWE without NCC (n=177). PWE and NCC who were compliant with anti-epileptic medications had a significantly higher reduction of seizures (98.6% vs. 89.2%, p=0.046). Other characteristics such as gender, seizure frequency, compliance, past medical history, close contact with pigs, use of latrines and family history of seizures did not differ significantly between the two groups. The number of NCC lesions and active NCC lesions were significantly associated with a positive antibody result. The electroimmunotransfer blot, developed by the Centers for Disease Control and Prevention, was more sensitive than a commercial western blot, especially in PWE and cerebral calcifications. This is the first study to systematically compare the clinical characteristics of PWE due to NCC or other causes and to explore the utility of two different antibody tests for diagnosis of NCC in sub-Saharan Africa

Mapping Polar Bear Maternal Denning Habitat in the National Petroleum Reserve–Alaska with an IfSAR Digital Terrain Model

The National Petroleum Reserve–Alaska (NPR-A) in northeastern Alaska provides winter maternal denning habitat for polar bears (Ursus maritimus) and also has high potential for recoverable hydrocarbons. Denning polar bears exposed to human activities may abandon their dens before their young are able to survive the severity of Arctic winter weather. To ensure that wintertime petroleum activities do not threaten polar bears, managers need to know the distribution of landscape features in which maternal dens are likely to occur. Here, we present a map of potential denning habitat within the NPR-A. We used a fine-grain digital elevation model derived from Interferometric Synthetic Aperture Radar (IfSAR) to generate a map of putative denning habitat. We then tested the map’s ability to identify polar bear denning habitat on the landscape. Our final map correctly identified 82% of denning habitat estimated to be within the NPR-A. Mapped denning habitat comprised 19.7 km2 (0.1% of the study area) and was widely dispersed. Though mapping denning habitat with IfSAR data was as effective as mapping with the photogrammetric methods used for other regions of the Alaskan Arctic coastal plain, the use of GIS to analyze IfSAR data allowed greater objectivity and flexibility with less manual labor. Analytical advantages and performance equivalent to that of manual cartographic methods suggest that the use of IfSAR data to identify polar bear maternal denning habitat is a better management tool in the NPR-A and wherever such data may be available.La réserve pétrolière nationale–Alaska (NPR-A), située dans le nord-est de l’Alaska (NPR-A), constitue un habitat hivernal de tanières de mise bas pour l’ours polaire (Ursus maritimus) et présente de grandes possibilités du point de vue des hydrocarbures récupérables. Les ours polaires des tanières qui sont exposés aux activités de l’être humain peuvent abandonner leur tanière avant que leurs petits ne soient prêts à survivre les rigueurs de l’hiver de l’Arctique. Afin de faire en sorte que les activités d’exploitation pétrolière hivernales ne posent pas de menaces aux ours polaires, les gestionnaires doivent connaître la répartition des caractéristiques du paysage où les tanières de mise bas sont susceptibles de se trouver. Ici, nous présentons une carte sur laquelle sont indiqués des habitats de tanières possibles au sein de la NPR-A. Nous avons utilisé un système de modélisation numérique des hauteurs à haute définition dérivé du radar interférométrique à synthèse d’ouverture (IfSAR) pour produire une carte putative de l’habitat de tanières. Ensuite, nous avons mis la carte à l’épreuve pour déterminer son aptitude à repérer l’habitat de tanières de mise bas au sein du paysage. Notre carte finale a repéré avec exactitude 82 % de l’habitat de tanières qui se trouverait à l’intérieur de la NPR-A. L’habitat de tanières cartographié s’étendait sur 19,7 km2 (0,1 % de l’aire étudiée) et était largement dispersé. Même si la cartographie de l’habitat de tanières au moyen des données de l’IfSAR était aussi efficace que la cartographie des méthodes photogrammétriques employées dans d’autres régions de la plaine côtière arctique de l’Alaska, l’utilisation du SIG pour analyser les données de l’IfSAR a donné lieu à une plus grande objectivité et flexibilité, avec moins de main-d’oeuvre. Les avantages analytiques et l’exécution équivalant à celles des méthodes de carto-graphie manuelles suggèrent que le recours aux données de l’IfSAR pour repérer l’habitat de tanières de mise bas d’ours polaires constitue un outil de gestion supérieur au sein de la NPR-A et de n’importe quel autre endroit où ces données sont disponibles

Evaluation of an immunodot blot technique for the detection of antibodies against Taenia solium larval antigens

Immunodiagnostic tests represent an important tool for diagnosis of cysticercosis, the disease caused by cysticerci of Taenia solium. Accurate diagnosis of neurocysticercosis (NCC) requires costly neuroimaging techniques (magnetic resonance imaging and computed tomography), which are seldom affordable for people in endemic countries. Hence, new low-cost diagnostic methods offering good sensitivity and specificity are needed. Here, we studied four immunodiagnostic tests immunodot blot Tsol-p27, a commercial ELISA, and Western blot Tsol-p27/TsolHSP36, and compared them with a commercial enzyme-linked immunoelectrotransfer blot (EITB) that we regarded as the gold standard method. The analyzed serum samples were obtained from 160 patients: 94 epileptics suspected of NCC, six individuals confirmed NCC-positive, and 60 with positive (30) or negative (30) serology for Chagas diseases. Of the 100 serum samples from epileptic patients, 13 were positive and 87 negative by EITB. Compared to Western blot Tsol-p27, immunodot blot Tsol-p27 offered similar specificity (97.8% vs. 95.6%) but better sensitivity (86.7% vs. 76.4%). The ELISA was similar to the immunodot blot Tsol-p27 regarding both sensitivity and specificity. Western blot TsolHSP36 provided the lowest sensitivity (61.9%) and specificity (86.1%). None of the antibodies in the serum samples from the Chagas control groups were recognized by immunodot blot Tsol-p27. Our results indicate that the immunodot blot Tsol-p27 provides good sensitivity and specificity. Furthermore, considering the simplicity and low cost of this test, it might be preferable as a diagnostic method in poorly equipped laboratories in endemic countries

Supranational Rules, National Discretion: Increasing versus Inflating Regulatory Bank Capital?

We study how banks use “regulatory adjustments” to inflate their regulatory capital ratios and whether this depends on forbearance on the part of national authorities. Using the 2011 EBA capital exercise as a quasi-natural experiment, we find that banks substantially inflated their levels of regulatory capital via a reduction in regulatory adjustments — without a commensurate increase in book equity and without a reduction in bank risk. We document substantial heterogeneity in regulatory capital inflation across countries, suggesting that national authorities forbear their domestic banks to meet supranational requirements, with a focus on short-term economic considerations