Alien Registration- Simansky, S (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/32001/thumbnail.jp

How dose of biochar and biochar with nitrogen can improve the parameters of soil organic matter and soil structure?

Biochar application to agricultural soils has a significant potential to influence soil resource availability and thus crop performance. A factorial experiment investigating effects of different biochar application rates combined with nitrogen fertilizer was conducted in field conditions on a Haplic Luvisol. The aim of this study was to evaluate the effects of biochar and biochar combined with fertilization on soil organic matter and soil structure parameters. The treatments comprised combinations of biochar application of 0, 10 and 20 t ha−1 (B0, B10 and B20) and 0, 40 and 80 kg N ha−1 of nitrogen fertilizer (N0, N40, N80) applied in a full-factorial design. Biochar application rate of 20 t ha−1 significantly increased soil organic carbon content (SOC) and non-labile carbon content (CNL), but decreased carbon lability (LC). The addition of biochar at 10 t ha−1 together with 40 and 80 kg N ha−1 significantly increased the values of SOC and CNL. On the other hand, B10N80 treatment resulted in a considerable decrease of carbon lability (LC). Overall, the lowest average content of water-stable micro-aggregates was found in the B20N80 treatment and then with B10N0 < B20N40 < B20N0 < B10N80 < B0N0 < B10N40. Biochar applied at 20 t ha−1 increased the critical level of soil organic matter and decreased the crusting index

Central Serotonin and Melanocortin Pathways Regulating Energy Homeostasis

It is now established that the hypothalamus is essential in coordinating endocrine, autonomic, and behavioral responses to changes in energy availability. However, the interaction of key peptides, neuropeptides, and neurotransmitters systems within the hypothalamus has yet to be delineated. Recently, we investigated the mechanisms through which serotonergic (5-hydroxytryptamine, 5-HT) systems recruit leptin-responsive hypothalamic pathways, such as the melanocortin systems, to affect energy balance. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we found that 5-HT drugs require functional melanocortin pathways to exert their effects on food intake. Specifically, we observed that anorectic 5-HT drugs activate pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (Arc). We provide evidence that the serotonin 2C receptor (5-HT2CR) is expressed on POMC neurons and contributes to this effect. Finally, we found that 5-HT drug-induced hypophagia is attenuated by pharmalogical or genetic blockade of downstream melanocortin 3 and 4 receptors. We review candidate brain regions expressing melanocortin 3 and 4 receptors that play a role in energy balance. A model is presented in which the activation of the melanocortin system is downstream of 5-HT and is necessary to produce the complete anorectic effect of 5-HT drugs. The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus

Interaction of Naturally Occurring Phytoplankton with the Biogeochemical Cycling of Mercury in Aquatic Environments and Its Effects on Global Hg Pollution and Public Health

The biogeochemical cycling of mercury in aquatic environments is a complex process driven by various factors, such as ambient temperature, seasonal variations, methylating bacteria activity, dissolved oxygen levels, and Hg interaction with dissolved organic matter (DOM). As a consequence, part of the Hg contamination from anthropogenic activity that was buried in sediments is reinserted into water columns mainly in highly toxic organic Hg forms (methylmercury, dimethylmercury, etc.). This is especially prominent in the coastal shallow waters of industrial regions worldwide. The main entrance point of these highly toxic Hg forms in the aquatic food web is the naturally occurring phytoplankton. Hg availability, intake, effect on population size, cell toxicity, eventual biotransformation, and intracellular stability in phytoplankton are of the greatest importance for human health, having in mind that such Hg incorporated inside the phytoplankton cells due to biomagnification effects eventually ends up in aquatic wildlife, fish, seafood, and in the human diet. This review summarizes recent findings on the topic of organic Hg form interaction with natural phytoplankton and offers new insight into the matter with possible directions of future research for the prevention of Hg biomagnification in the scope of climate change and global pollution increase scenarios.This research was funded by the Spanish Ministry of Economic Transformation, Industry, Knowledge and Universities; by the European Regional Development Fund (FEDER) within the framework of the FEDER program of Andalusia (Spain) 2014–2020 (grant number: UHU–202065); and by grant P20-00930 from the Andalusian Plan for Research, Development and Innovation, within the frame of the operational program “FEDER Andalucía 2014–2020”. The work of S.S. was supported by project number FCH-S-23-8330 of the Faculty of Chemistry, Brno University of Technology, Brno, Czech Republic

The Influence of Different Fertilization Strategies on the Grain Yield of Field Peas (Pisum sativum L.) under Conventional and Conservation Tillage

Weather, tillage, and fertilization are the major factors affecting the grain yield of field peas (Pisum sativum L.). However, the impact of tillage and fertilization on yield is not well understood. Therefore, this experiment was initiated in 1999. In this manuscript, we report the data recorded during the period of 2011-2015 to quantify the impacts on yield. Field peas were planted in seedbeds prepared through conventional tillage (CT)-moldboard ploughing to the depth of 0.22 m; and minimum tillage (MT)-disking to the depth of 0.12 m. The crop received three fertilization treatments, including zero fertilization (control); nitrogen, phosphorus and potassium (NPK) mineral fertilization treatment; and NPK mineral fertilization plus the incorporation of pre-crop biomass. Five years' average data indicated the highest yield on fertilized treatments (2.85-2.98 t ha(-1) vs. 2.66 t ha(-1)) regardless of the tillage. When comparing the yield of fertilized treatments, the yield under CT (2.98 t ha(-1)) was significantly higher than that of MT (2.85 t ha(-1)). However, on non-fertilized treatments (less fertile plots), a higher yield was recorded under MT (2.71 t ha(-1)) compared with CT (2.40 t ha(-1)). Overall, the results of this study suggest that fertilizer application together with incorporation of the above-ground biomass of the previous crop may help sustain pea grain yield

Comparative effectiveness of intensity modulated radiation therapy to 3-dimensional conformal radiation in locally advanced lung cancer: pathological and clinical outcomes.

OBJECTIVE: Intensity-modulated radiotherapy (IMRT) has better normal-tissue sparing compared with 3-dimensional conformal radiation (3DCRT). We sought to assess the impact of radiation technique on pathological and clinical outcomes in locally advanced non-small cell lung cancer (LANSCLC) treated with a trimodality strategy. METHODS: Retrospective review of LANSCLC patients treated from August 2012 to August 2018 at Sheba Medical Center, Israel. The trimodality strategy consisted of concomitant chemoradiation to 60 Gray (Gy) followed by completion surgery. The planning target volume (PTV) was defined by co-registered PET/CT. Here we compare the pathological regression, surgical margin status, local control rates (LC), disease free (DFS) and overall survival (OS) between 3DCRT and IMRT. RESULTS: Our cohort consisted of 74 patients with mean age 62.9 years, male in 51/74 (69%), adenocarcinoma in 46/74 (62.1%), stage 3 in 59/74 (79.7%) and chemotherapy in 72/74 (97.3%). Radiation mean dose: 59.2 Gy (SD ± 3.8). Radiation technique : 3DCRT in 51/74 (68.9%), IMRT in 23/74 (31%). Other variables were similar between groups.Major pathological response (including pathological complete response or less than 10% residual tumor cells) was similar: 32/51 (62.7%) in 3DCRT and 15/23 (65.2%) in IMRT, p=0.83. Pathological complete response (pCR) rates were similar: 17/51 (33.3%) in 3DCRT and 8/23 (34.8%) in IMRT, p=0.9. Surgical margins were negative in 46/51 (90.1%) in 3DCRT vs. 17/19 (89.4%) in IMRT (p=1.0).The 2-year LC rates were 81.6% (95% CI 69-89.4%); DFS 58.3% (95% CI 45.5-69%) and 3-year OS 70% (95% CI57-80%). Comparing radiation techniques, there were no significant differences in LC (p=0.94), DFS (p=0.33) and OS (p=0.72). CONCLUSION: When used to treat LANSCLC in the neoadjuvant setting, both IMRT and 3DCRT produce comparable pathological and clinical outcomes. ADVANCES IN KNOWLEDGE: This study validates the real-world effectiveness of IMRT compared to 3DCRT

Long-term results of diaphragmatic plication in adults with unilateral diaphragm paralysis

<p>Abstract</p> <p>Background</p> <p>In this study we aimed to evaluate the long-term outcome of diaphragmatic plication for symptomatic unilateral diaphragm paralysis.</p> <p>Methods</p> <p>Thirteen patients who underwent unilateral diaphragmatic plication (2 patients had right, 11 left plication) between January 2003 and December 2006 were evaluated. One patient died postoperatively due to sepsis. The remaining 12 patients [9 males, 3 females; mean age 60 (36-66) years] were reevaluated with chest radiography, flouroscopy or ultrasonography, pulmonary function tests, computed tomography (CT) or magnetic resonance imaging (MRI), and the MRC/ATS dyspnea score at an average of 5.4 (4-7) years after diaphragmatic plication.</p> <p>Results</p> <p>The etiology of paralysis was trauma (9 patients), cardiac by pass surgery (3 patients), and idiopathic (1 patient). The principle symptom was progressive dyspnea with a mean duration of 32.9 (22-60) months before surgery. All patients had an elevated hemidiaphragm and paradoxical movement radiologically prior to surgery. There were partial atelectasis and reccurent infection of the lower lobe in the affected side on CT in 9 patients. Atelectasis was completely improved in 9 patients after plication. Preoperative spirometry showed a clear restrictive pattern. Mean preoperative FVC was 56.7 ± 11.6% and FEV1 65.3 ± 8.7%. FVC and FEV1 improved by 43.6 ± 30.6% (p < 0.001) and 27.3 ± 10.9% (p < 0.001) at late follow-up. MRC/ATS dyspnea scores improved 3 points in 11 patients and 1 point in 1 patient at long-term (p < 0.0001). Eight patients had returned to work at 3 months after surgery.</p> <p>Conclusions</p> <p>Diaphragmatic plication for unilateral diaphragm paralysis decreases lung compression, ensures remission of symptoms, and improves quality of life in long-term period.</p

Alien Registration- Simansky, S (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/32001/thumbnail.jp