Experimental pharmacological research regarding some newly synthesized benzamides on central nervous system functions

Three newly synthesized benzamides by the Department of Pharmaceutical Chemistry of the Faculty of pharmacy from the University of Medicine and Pharmacy „Carol Davila” Bucharest were tested in order to determine whether these new molecules have similar effects on the central nervous system as those already in therapeutic use belonging to the same chemical group, such as tiapride (neuroleptic) or lidocaine (local anaesthetic). Tests were carried out on NMRI mice which were given new compounds, conventionally named I5C, I14C, and II5C in a dose of 1/20 of the lethal dose 50% (LD50), as previously determined. They received this treatment daily for 21 days. The evasive–investigating capacity of mice was determined using the platform test, and the motor activity using an Activity cage device. The results have shown that compounds I5C and II5C decrease the investigation capacity of the mice; and compound I5C inhibits motor activity, while II5C stimulates it. Thus we concluded that only compounds I5C and II5C have a neuroleptic potential that might be investigated further

Effect of multiple episodes of Acute Kidney Injury on mortality:an observational study

Background Patients who survive an episode of acute kidney injury (AKI) are more likely to have further episodes of AKI. AKI is associated with increased mortality, with a further increase with recurrent episodes. It is not clear whether this is due to AKI or as a result of other patient characteristics. The aim of this study was to establish whether recurrence of AKI is an independent risk factor for mortality or if excess mortality is explained by other factors. Methods This observational cohort study included adult people from the Tayside region of Scotland, with an episode of AKI between 1 January 2009 and 31 December 2009. AKI was defined using the creatinine-based Kidney Disease: Improving Global Outcomes definition. Associations between recurrent AKI and mortality were examined using a Cox proportional hazards model. Results Survival was worse in the group identified to have recurrent AKI compared with those with a single episode of AKI [hazard ratio = 1.49, 95% confidence interval (CI) 1.37–1.63; P

The Evolution of Trade and Technological in the Italian regions

The deepening of the integration process with the acceleration of the Single European Market (SEM), the forthcoming adoption of a single currency together with the political plans of eastwards enlargement of the European Union (EU%29 rise problems of disparities and inequalities between and within member states. The existence of cross-border imbalances within the EU area and the relevance of the issue for a successful socio-economic integration have been widely pointed out by the literature. The convergence in GDP levels across the EU regions registered up to the 1970s slowed down in the 1980s and started to reverse in the early 1990s. The awareness of this phenomenon has promoted the flourishing of socio-economic investigations based on the region as a territorial unit of analysis in order to better understand local dynamics driving convergence/divergence processes. Amidst the more general globalisation trend, localised knowledge spillovers and geographical concentration of economic activity seem to underlie these processes. In fact, despite of the fast pace of technological change and the massive reduction of space and time constrains, geographical agglomeration matters more than ever before for the purpose of global competitiveness. If the geographical perspective has shifted from the national to the regional level in the investigation of growth differentials, it has also turned out that innovative capabilities account for a good deal in explaining inter-regional disparities. The latter seem to greatly depend upon local innovative capacities, without, however, disregarding economic-structural and institutional factors. Structural and innovative processes are closely connected and mutually reinforced by virtuous and vicious circles%2C characterising respectively “success stories” of rapid industrial and technological development and catching up, and “falling behind” models of insufficient structural change and lack of organisational flexibility and systemic interaction. Within the European arena, the heterogeneous socio-economic conditions of the Italian regions are a clear example of intra-border imbalances. In the Italian peninsula, the north-south gap, reflected in the distinction between most advanced and less favoured regions, calls for a better understanding of both structural and technological profiles of the regional sectoral systems. By providing further insight into the convergence/divergence processes of regional industrial systems in Italy, this paper will attempt to identify production and innovative potentials developed within each regional unit. The ultimate aim is to explain current leading and lagging-behind conditions as well as to focus on the developing trajectories of consolidation and redefinition of regional competitive positions. For this purpose, economic, technological and locational factors will be evaluated. As the heterogeneity of the Italian regional systems is far to be an exception in the EU, the results of this analysis and their policy implications may well be relevant to the domestic realities of other member states. Going into the details of the analysis, the paper tests the hypothesis of whether technology effort impacts on regional internationalisation (understood in terms of international trade) over time. In doing so, the evolution of sectoral trade specialisation is sketched in order to evaluate the trajectories of regional competitive patterns. The emphasis on the sectoral aspects shed some light on the knowledge exchange and learning underlying trade flows. Moreover, in order to evaluate the significance of cross-regional differences in this context, the investigation goes further by identifying regional profiles of production structure.

Thermal Effects in Anisotropic Porous Elastic Rods

This research is concerned with the thermoelastic deformation of a porous anisotropic right cylinder subjected to a thermal field independent of the axial coordinate. The case of a material with a plane of elastic symmetry which contains the axis of cylinder is considered. The solution of the problem is expressed in terms of solutions of some generalized plane strain problems. It is shown that the temperature field produces extension, torsion, and a plane strain. For this kind of anisotropy, an infinitesimal twist produces a variation of volume fraction field. The method is used to study the deformation of an inhomogeneous circular cylinder

The Evolution of Trade and Technological in the Italian regions

The deepening of the integration process with the acceleration of the Single European Market (SEM), the forthcoming adoption of a single currency together with the political plans of eastwards enlargement of the European Union (EU%29 rise problems of disparities and inequalities between and within member states. The existence of cross-border imbalances within the EU area and the relevance of the issue for a successful socio-economic integration have been widely pointed out by the literature. The convergence in GDP levels across the EU regions registered up to the 1970s slowed down in the 1980s and started to reverse in the early 1990s. The awareness of this phenomenon has promoted the flourishing of socio-economic investigations based on the region as a territorial unit of analysis in order to better understand local dynamics driving convergence/divergence processes. Amidst the more general globalisation trend, localised knowledge spillovers and geographical concentration of economic activity seem to underlie these processes. In fact, despite of the fast pace of technological change and the massive reduction of space and time constrains, geographical agglomeration matters more than ever before for the purpose of global competitiveness. If the geographical perspective has shifted from the national to the regional level in the investigation of growth differentials, it has also turned out that innovative capabilities account for a good deal in explaining inter-regional disparities. The latter seem to greatly depend upon local innovative capacities, without, however, disregarding economic-structural and institutional factors. Structural and innovative processes are closely connected and mutually reinforced by virtuous and vicious circles%2C characterising respectively “success stories” of rapid industrial and technological development and catching up, and “falling behind” models of insufficient structural change and lack of organisational flexibility and systemic interaction. Within the European arena, the heterogeneous socio-economic conditions of the Italian regions are a clear example of intra-border imbalances. In the Italian peninsula, the north-south gap, reflected in the distinction between most advanced and less favoured regions, calls for a better understanding of both structural and technological profiles of the regional sectoral systems. By providing further insight into the convergence/divergence processes of regional industrial systems in Italy, this paper will attempt to identify production and innovative potentials developed within each regional unit. The ultimate aim is to explain current leading and lagging-behind conditions as well as to focus on the developing trajectories of consolidation and redefinition of regional competitive positions. For this purpose, economic, technological and locational factors will be evaluated. As the heterogeneity of the Italian regional systems is far to be an exception in the EU, the results of this analysis and their policy implications may well be relevant to the domestic realities of other member states. Going into the details of the analysis, the paper tests the hypothesis of whether technology effort impacts on regional internationalisation (understood in terms of international trade) over time. In doing so, the evolution of sectoral trade specialisation is sketched in order to evaluate the trajectories of regional competitive patterns. The emphasis on the sectoral aspects shed some light on the knowledge exchange and learning underlying trade flows. Moreover, in order to evaluate the significance of cross-regional differences in this context, the investigation goes further by identifying regional profiles of production structure

Flux-ratio anomalies from discs and other baryonic structures in the Illustris simulation

The flux ratios in the multiple images of gravitationally lensed quasars can provide evidence for dark matter substructure in the halo of the lensing galaxy if the flux ratios differ from those predicted by a smooth model of the lensing galaxy mass distribution. However, it is also possible that baryonic structures in the lensing galaxy, such as edge-on discs, can produce flux-ratio anomalies. In this work, we present the first statistical analysis of flux-ratio anomalies due to baryons from a numerical simulation perspective. We select galaxies with various morphological types in the Illustris simulation and ray-trace through the simulated halos, which include baryons in the main lensing galaxies but exclude any substructures, in order to explore the pure baryonic effects. Our ray-tracing results show that the baryonic components can be a major contribution to the flux-ratio anomalies in lensed quasars and that edge-on disc lenses induce the strongest anomalies. We find that the baryonic components increase the probability of finding high flux-ratio anomalies in the early-type lenses by about 8% and by about 10 - 20% in the disc lenses. The baryonic effects also induce astrometric anomalies in 13% of the mock lenses. Our results indicate that the morphology of the lens galaxy becomes important in the analysis of flux-ratio anomalies when considering the effect of baryons, and that the presence of baryons may also partially explain the discrepancy between the observed (high) anomaly frequency and what is expected due to the presence of subhalos as predicted by the CDM simulations.Comment: 16 pages, 11 figures, accepted by MNRA