A space-time generator for rainfall nowcasting: the PRAISEST model

International audienceThe paper introduces a new stochastic technique for forecasting rainfall in space-time domain: the PRAISEST Model (Prediction of Rainfall Amount Inside Storm Events: Space and Time). The model is based on the assumption that the rainfall height H accumulated on an interval ?t between the instants i?t and (i+1)?t and on a spatial cell of size ?x?y is correlated either with a variable Z, representing antecedent precipitation at the same point, either with a variable W, representing simultaneous rainfall at neighbour cells. The mathematical background is given by a joined probability density fH,W,Z (h,w,z) in which the variables have a mixed nature, that is a finite probability for null value and infinitesimal probabilities for the positive values. As study area, the Calabria region, in Southern Italy, has been selected. The region has been discretised by 10 km×10 km cell grid, according to the raingauge network density in this area. Storm events belonging to 1990?2004 period were analyzed to test performances of the PRAISEST model

Disjoint pattern matching and implication in strings

We deal with the problem of whether a set of string patterns implies the presence of a fixed pattern. While checking whether a set of patterns occurs in a string is solvable in polynomial time, this implication problem is well-known to be intractable. Here we consider a version of the problem when patterns in the set are required to be disjoint. We show that for such a version of the problem the situation is reversed: checking whether a set of patterns occurs in a string is NP-complete, but the implication problem is solvable in polynomial time. 1 Introduction and the main result The problem we consider in this note was motivated by answering queries in incompletely specified XML documents. Suppose that L is a set of letters, or labels, assumed to be countably infinite, and that is a special symbol (wildcard) not in L. By L we denote L∪ {}. A pattern is a finite string over L. If a string s over L matches a pattern π, we write s | = π. More precisely, if s = a0...an−1 an

Rainfall nowcasting by at site stochastic model P.R.A.I.S.E.

The paper introduces a stochastic model to forecast rainfall heights at site: the P.R.A.I.S.E. model (Prediction of Rainfall Amount Inside Storm Events). PRAISE is based on the assumption that the rainfall height <I>H_i</I>+1 accumulated on an interval &Delta;<I>t</I> between the instants <I>i&Delta;t</I> and <I>(i+1&Delta;t</I> is correlated with a variable <I>Z_i^(&nu;)</I>, representing antecedent precipitation. The mathematical background is given by a joined probability density <I>f_{H_i+1}, Z_i^(&nu;)(h_i+1 ,z_i^(&nu;)</I>) in which the variables have a mixed nature, that is a finite probability in correspondence to the null value and infinitesimal probabilities in correspondence to the positive values. As study area, the Calabria region, in Southern Italy, was selected, to test performances of the PRAISE model

Skepticism and humanism in Forster's treatment of personal relations

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Florianópolis, 1981

W-F substitutions in apomyoglobin increase the local flexibility of the N-terminal region causing amyloid aggregation: A H/D exchange study.

Myoglobin is an α-helical globular protein containing two highly conserved tryptophanyl residues at positions 7 and 14 in the N-terminal region. The simultaneous substitution of the two residues impairs the productive folding of the protein making the polypeptide chain highly prone to aggregate forming amyloid fibrils at physiological pH and room temperature. The role played by tryptophanyl residues in driving the productive folding process was investigated by providing structural details at low resolution of compact intermediate of three mutated apomyoglobins, i.e., W7F, W14F and the amyloid forming mutant W7FW14F. In particular, we followed the hydrogen/deuterium exchange rate of protein segments using proteolysis with pepsin followed by mass spectrometry analysis. The results revealed significant differences in the N-terminal region, consisting in an alteration of the physico-chemical properties of the 7-11 segment for W7F and in an increase of local flexibility of the 12-29 segment for W14F. In the double trypthophanyl substituted mutant, these effects are additive and impair the formation of native-like contacts and favour inter-chain interactions leading to protein aggregation and amyloid formation at physiological pH

A word about Charlotte Brontë and her critics

Trata-se de apresentar alguns comentários sobre a influência exercida por críticos e resenhistas de escritores vivos sobre o processo de elaboração desses autores. A partir de algumas considerações sobre o papel e a função do crítico literário, são narrados alguns aspectos da relação entre a escritora vitoriana Charlotte Brontê com seus críticos e editores

Life force and death force in Lawrence's sons and lovers

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Understanding the role of protein glycation in the amyloid aggregation process

Protein function and flexibility is directly related to the native distribution of its structural elements and any alteration in protein architecture leads to several abnormalities and accumulation of misfolded proteins. This phenomenon is associated with a range of increasingly common human disorders, including Alzheimer and Parkinson diseases, type II diabetes, and a number of systemic amyloidosis characterized by the accumulation of amyloid aggregates both in the extracellular space of tissues and as intracellular deposits. Post-translational modifications are known to have an active role in the in vivo amyloid aggregation as able to affect protein structure and dynamics. Among them, a key role seems to be played by non-enzymatic glycation, the most unwanted irreversible modification of the protein structure, which strongly affects long-living proteins throughout the body. This study provided an overview of the molecular effects induced by glycation on the amyloid aggregation process of several protein models associated with misfolding diseases. In particular, we analyzed the role of glycation on protein folding, kinetics of amyloid formation, and amyloid cytotoxicity in order to shed light on the role of this post-translational modification in the in vivo amyloid aggregation process

Hydroxytyrosol Prevents Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes

Doxorubicin (Dox) is a highly effective chemotherapeutic agent employed in the handling of hematological and solid tumors. The effective use of Dox in cancer therapy has been seriously limited due to its well-known cardiotoxic side effects, mainly mediated by oxidative damage. Therefore, the identification of an effective and safe antagonist against Dox-induced cardiotoxicity remains a challenge. In this respect, as plant polyphenols have attracted considerable interest due to their antioxidant properties and good safety profile, hydroxytyrosol (HT), the major phenolic compound in olive oil, could be a potential candidate due to its remarkable antioxidant and anticancer powers. In this study, the effect of HT was tested on Dox-induced cardiotoxicity by using a combination of biochemical and cellular biology techniques. Interestingly, HT was able to counteract Dox-induced cytotoxicity in cardiomyocytes by acting on the SOD2 level and the oxidative response, as well as on apoptotic mechanisms mediated by Bcl-2/Bax. At the same time, HT did not to interfere with the antitumorigenic properties of Dox in osteosarcoma cells. This study identifies new, beneficial properties for HT and suggests that it might be a promising molecule for the development of additional therapeutic approaches aimed at preventing anthracycline-related cardiotoxicity and improving long-term outcomes in antineoplastic treatments