To analyze the functional outcome of proximal tibial fractures treated with minimally invasive percutaneous plate osteosynthesis technique

Background: Tibial plateau fractures constitute about 1% of all fractures and complex bicondylar fractures constitute 30% of all Tibial plateau fractures. Minimally Invasive Percutaneous Plate Osteosynthesis [MIPPO] is a method of biological fixation in which a plate is percutaneously inserted and fixed at a distance proximally and distally from the fracture site. By minimal exposure, this helps in the preservation of the essential fracture hematoma, minimal soft tissue dissection, avoidance of periosteal stripping and providing an adequate fixation. The objective of the study was to analyze the functional outcome of proximal Tibial fractures treated with MIPPO technique. The method of fixation shall be evaluated for the time period required for the patients to return to active work following surgery.Methods: In our study, all 18 patients with proximal Tibial fractures underwent definitive fixation by MIPPO technique. All our cases underwent initial stabilization as per the ATLS guidelines. Patients with closed Tibial plateau fractures associated with a tense haemarthrosis underwent aspiration of the joint under aseptic precautions. The limb was immobilized either in an above knee slab or through skeletal traction using a distal Tibial or calcaneal pin traction on a Bohler Braun splint until definitive fixation was carried out. In cases complicated with excessive swelling and blistering, definitive fixation was delayed until the swelling/ blistering subsided.Results: The post-operative results were designated as excellent, good, fair and poor according to pain, walking capacity, the range of motion and stability of the knee using Rasmussen’s grading system. In our study, the average functional knee score was 22.89. Rasmussen’s score does not consider articular congruity while assessing the functional outcome of the knee.Conclusions: MIPPO technique gives good to excellent results even in high energy Tibial condyle fractures [72.22% cases in our study]. Our patients were able to achieve a good functional range of movement, averaging 120 degrees. [Krettek et al – 124 degrees]. Those who were treated with early fixation and early mobilization were found to have a better functional outcome irrespective of the fracture type. No secondary bone grafting was required.

Surgical management of proximal humerus fracture treated with locking compression plate

Background: Proximal humerus fractures accounts for about 4 to 5% of all fractures.  Treatment of unstable, displaced, and comminuted fractures of the proximal humerus remain challenging. Significant controversy continues regarding the best methods of treating displaced proximal humerus fractures. Various operative procedures are carried out, the recent trend in internal fixation has moved on to locking plates. The present study is undertaken to evaluate the functional outcome and complication of proximal humerus fractures treated by locking compression plate.Methods: This is a prospective study comprising of 30 patients with fractures of proximal humerus were treated by open reduction and internal fixation with locking compression plate were evaluated at Velammal  Institute Of Medical  Sciences, Madurai from the period of April 2015 to December 2016. Clinical and radiological evaluation was done. Patients will undergo open reduction internal fixation with locking compression plate for the sustained fracture under general anesthesia.Results: In our series, the majority of the patients were males, elderly aged, with RTA being the commonest mode of injury, involving 2 part, 3 part and 4 part fractures of the proximal humerus. Excellent and satisfactory results were found in 76.7% of patients with unsatisfactory results in 23.3 % according to Neer’s criteria. There were 100 % union rates and no failures.Conclusions: In conclusion locking Compression, the plate is an advantageous implant in proximal humeral fractures due to angular stability, particularly in comminuted fractures and in Osteoporotic bones in elderly patients, thus allowing early mobilization

Regeneration of Invitro Plantlets in Hemidesmus indicus (L.) R. Br. through Nodal and Leaf Explants

Invitro plantlet regeneration of Hemidesmus indicus (L.) R.Br, through nodal and leaf explants were attempted by culturing on MS medium supplemented with various PGRs. Nodal and leaf explants induced callus on media containing 2,4-D, 2,4,5-T, 2ip, IAA, NAA, BAP and KIN. The highest frequency of callus was observed in the leaf explants supplemented with 1.0, 3.0, 5.0 mgL-1 concentration of IAA, NAA, IBA. Rhizogenesis was observed in leaf explants highly in Auxin treatment like 2,4-D and 2,4,5-T with the concentrations of 0.2 mgL-1 and 0.5 mgL-1 respectively. Shoot differentiation was obtained from the callus of nodal explants on MS-medium with 1.0, 3.0, 5.0 mgL-1 of 2,4,5-T, KIN and BAP. Regenerated shoots showed rhizogenesis in MS-medium supplemented with 0.5 mgL-1 of IBA and KIN. Eight week old rooted invitro plantlets of H.indicus were removed from the culture vessels and transplanted into plastic pots. The plantlets were exposed to a relative humidity of 80%-90% and temperature 28±2ºC during day time, and 24 ±2ºC during night time. The percentage of surviving plantlets were recorded after four weeks of acclimatization. More than 95% of acclimatized plantlets grew vigorously without any morphological abnormalities

Perceptions and Prospects: Technology-Enabled Teacher Education in the Digital Age

The integration of technology into education has led to significant transformations in teacher education programs. This study examines the perceptions of learners regarding technology-enabled teacher education programs. It explores the experiences and viewpoints of a diverse group of teacher education students, ranging from pre-service teachers to experienced educators pursuing advanced qualifications. The study reveals that learners generally perceive technology-enabled teacher education programs positively, highlighting advantages such as increased accessibility, flexibility, engagement, and personalization. However, they also acknowledge challenges related to technical issues and the digital divide. These findings emphasize the importance of ongoing research and development in technology integration within teacher education to better prepare educators for the digital age classroom

Governing Social Bodies: Affect and Number in Contemporary Cricket

Two recent cybernetics-derived academic disciplines, biomechanics and operations research, have worked to reshape cricket. Liberalization and the consequent large flows of money into the game have resulted in a transformation in how the game is regulated, coached, and played. In this dissertation, I have focused on how cricket is now being produced through an account of the use of biomechanics in the regulating and coaching of cricket and an appraisal of the role that operations research plays in regulating interruptions to individual games of cricket. I argue that these twin developments correspond to Foucault's notion of a contemporary governmentality organized around the body as machine and the species of body, respectively. A consideration of the manner in which cybernetics underpins these practices and theories broadens and deepens accounts of both how the contemporary world is continually being shaped and being studied

MOLECULAR DOCKING, DESIGN, SYNTHESIS, IN VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY EVALUATIONS OF NEW ISOQUINOLINE DERIVATIVES

Objectives: To design and synthesis N-substituted (E)-4-arylidene-isoquinoline-1,3-dione derivatives as anti-inflammatory and antioxidant drug moieties using molecular docking as a tool.Methods: The structure of compounds (5a-h) was elucidated by means of FT-IR, GC-MS and NMR spectroscopy. Molecular docking was carried out to clarify the molecular aspects of the observed COX-inhibitory activities of the investigated compounds. DPPH radical scavenging analysis method was used to determine antioxidant activity and in-vitro anti-Inflammatory activity was conducted by Human Red Blood Cell (HRBC) membrane stabilization method utilizing Diclofenac sodium as standard.Results: Isoquinoline (N-substituted (E)-4-arylidene-isoquinoline-1,3-dione) derivatives were achieved using oxalic acid as the catalyst, by aldol condensation of the corresponding aldehydes and the corresponding N-substituted homophthalimides with a maximum yield of 92%. Ligand efficiency (LE) consequences being a clear indication that the action potential of the compounds 5e (-0.72) and 5d (-0.64) is high when compare with the standard (-0.63) for COX-1. While for COX-2, compounds 5e (-0.81) 5d (-0.79) and 5h (-0.98) were shown a remarkable ligand efficiency than the standard (-0.65). Anti-inflammatory and antioxidant studies on the compounds 5h<5d<5g was found best activity results.Conclusion: From our overall studies, it was understood that the activities of both in silico and in vitro anti-inflammatory results are coincide together. The p-values were significant for all the compounds 5(a-h) in both COX-1 and COX-2 activities which indicate that all the compounds have ‘competency' towards druggability for both anti-inflammatory and antioxidant, especially the compounds 5h<5d<5g<5e can be suggested for in vivo.Â

Variability analysis in tomato (Solanum lycopersicum L.) crosses under drought stress

Climate change in recent years has affected crop production to a greater extent. To overcome these effects, climate-resilient varieties are needed. Tomato is a versatile crop. However, its growth is hindered when it is affected by drought stress. Hence, a variability analysis of tomatoes under drought stress was carried out at Horticulture College and Research Institute, Coimbatore. Variability studies revealed that all the crosses for all parameters exhibited higher phenotypic coefficient of variation (PCV) values than genotypic coefficient of variation (GCV), indicating the influence of environmental effects. For all the crosses, viz., EC169966 × LE118, EC177824 × LE27 and Arka Ashish × LE27, high PCV and high GCV were recorded for characteristics including fruit number per plant, yield per plant, lycopene content and peroxidase activity. Characteristics such as the number of flowers per cluster, fruit number per plant, individual weight of fruit, yield per plant, relative water content, proline content, peroxidase activity and ascorbic acid content recorded higher heritability coupled with high genetic advance as a percentage of the mean (GAM). Thus, direct selection of the above parameters improves drought-tolerant breeding programs in tomato

Comprehensive Multivariate Analysis Of Rice (Oryza Sativa L.) Genotypes Of Tamil Nadu For Yield And Yield Attributed Traits

An experiment was performed to assess the variability parameters for biometrical traits in 104 rice genotypes. Higher estimates of GCV and PCV were found for single plant yield and filled grains per panicle along with high heritability and genetic advance. Single plant yield exhibited significant positive genotypic correlation for most of the yield contributing characters like number of productive tillers, number of filled grains per panicle, number of tillers, panicle length and thousand grain weight. The highest positive direct effects on yield were exhibited by number of filled grains per panicle followed by number of productive tillers at genotypic level for the improvement of rice yield. Estimates of genetic variability analysis exhibited, single plant yield and number of filled grains per panicle are positive for practically all variability factors tested. The study revealed high genetic variability, indicating that the genotypes could be utilized for further rice breeding

Green synthesis of silver nanoparticle using goniothalamus wightii on graphene oxide nanocomposite for effective voltammetric determination of metronidazole

Graphene oxide (GO) has piqued the interest of both academia and industry owing to its polar and two-dimensional (2D) layered structure. Antibiotic concentrations can be detected with advanced GO composites to reduce the risk of bacterial resistance, which can be done with electrochemical sensors. Herein, we have developed an eco-friendly synthesis approach, one-pot strategy towards Goniothalamus wightii biomass-derived solution preparation of Ag nanoparticle-decorated graphene oxide (GO@AgNPs) composites. As- synthesized GO@AgNPs nanocomposites were analyzed using various analytical tools including Raman, X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM). The Metronidazole (MIZ) determination was then investigated using cycle volumetric and amperometric (i-t) techniques by the GO@AgNPs composites. Prepared composites exhibit a wide-linear range of 0.09 μM to 4.594 mM, low detection limit of 69 nM and a limit of quantification detection of 786 nM. Furthermore, the practical applicability of the prepared GO@AgNPs nanocomposites were examined in pharmaceutical drug Flagyl (500 mg) with satisfactory recovery results

Impact of different nutrient management strategies on growth, yield components and yield of coloured cotton (Gossypium hirsutum L.) cv. Vaidehi 1

Cotton (Gossypium spp.), often referred to as “white gold” and “the king of fibers”, is a major commercial fiber crop cultivated across various agroclimatic conditions, primarily used in the textile industry to manufacture fabrics. However, conventional white cotton production is associated with several environmental challenges including excessive water consumption, reliance on synthetic chemicals and the use of synthetic dyes, which contribute to soil degradation, water pollution and health hazards for farmers. In contrast, organic coloured cotton presents a sustainable alternative by naturally producing coloured fibres without the need for synthetic dyes. Additionally, it enhances soil fertility, conserves water and minimizes chemical inputs, providing ecological benefits while supporting the well-being of farming communities. The field experiments were carried out at the Central Farm, Agricultural College and Research Institute, TNAU, Madurai, Tamil Nadu, during the Kharif 2023 and Summer 2024 seasons. The present study aimed to evaluate the impacts of various nutrient management practices on the growth characteristics, yield attributes and yield of coloured cotton (Gossypium hirsutum L.) cv. Vaidehi 1. The experiment was designed using a randomized block design with nine treatments based on N-equivalence using different organic manures compared to inorganic fertilizers and replicated three times. The results indicated a significant increase in the growth characters (plant height, number of vegetative branches plant−1 and number of fruiting branches plant−1), yield attributes (number of fruiting points plant−1, number of bolls plant−1, number of bolls m−2, boll setting % and boll weight) and yield (seed cotton yield, lint cotton yield, stalk yield and biological yield) of coloured cotton with the application of 100% NPK applied through site-specific recommendation (T2), which was statistically on par with 100% NPK through blanket recommendation (T1). These were followed by the organic treatments like complete organic package (T9), cover crop with vermicompost (T4), cover crop with poultry manure (T5) and all other organic treatments during both seasons. No significant variations were recorded in the first fruiting node, length of fruiting branches as well as harvest index and lint percentage across the different nutrient management strategies