The effect of particle size on the intrinsic dissolution of acetylsalicylic acid

Dissolution has an important role in the release of active ingredients from pharmaceutical preparations. The main focus of dissolution testing is in the area of quality control and product development, since the test yields information related to the composition and manufacturing variables. Moreover, the rate of dissolution is studied during the course of a new chemical entity development since it predicts potential bioavailability. The research objective of this study was to examine the dissolution rate of acetylsalicylic acid nondisintegrating compacts made up from four different particle sizes while exposing only a fixed surface area to the dissolution medium. This is also known as the rate of intrinsic dissolution, which is regarded as a characterization study and is therefore not referenced in individual monographs.peer-reviewe

Sonancia : sonification of procedurally generated game levels

How can creative elements brought from level design effectively be coupled with audio in order to create tense and engaging player experiences? In this paper the above question is posed through the sonification of procedurally generated digital game levels. The paper details some initial approaches and methodologies for achieving this core aim.The research is supported, in part, by the FP7 ICT project C2Learn (project no: 318480) and the FP7 Marie Curie CIG project AutoGameDesign (project no: 630665).peer-reviewe

Modelling virtual camera behaviour through player gaze

In a three-dimensional virtual environment, aspects such as narrative and interaction largely depend on the placement and animation of the virtual camera. Therefore, virtual camera control plays a critical role in player experience and, thereby, in the overall quality of a computer game. Both game industry and game AI research focus on the development of increasingly sophisticated systems to automate the control of the virtual camera integrating artificial intelligence algorithms within physical simulations. However, in both industry and academia little research has been carried out on the relationship between virtual camera, game-play and player behaviour. We run a game user experiment to shed some light on this relationship and identify relevant differences between camera behaviours through different game sessions, playing behaviours and player gaze patterns. Results show that users can be efficiently profiled in dissimilar clusters according to camera control as part of their gameplay behaviour.peer-reviewe

A constructive approach for the generation of underwater environments

This paper introduces Coralize, a library of generators for marine organisms such as corals and sponges. Using constructive algorithms, Coralize can generate stony corals via L-system grammars, soft corals via leaf venation algorithms and sponges via nutrient-based mesh growth. The generative algorithms are parameterizable, allowing a user to adjust the parameters in order to create visually appealing 3D meshes. Such meshes can be used to automatically populate a seabed or reef, in order to create a biologically realistic and aesthetically pleasing underwater environment.The research was supported, in part, by the FP7 ICT projects C2Learn (project no: 318480) and ILearnRW (project no: 318803), and by the FP7 Marie Curie CIG project AutoGameDesign (project no: 630665).peer-reviewe

Automatic threshold selection for BLM signals during LHC collimator beam-based alignment

The Large Hadron Collider at CERN is the largest high-energy particle accelerator in the world. Proton beams are currently collided at an energy of 4 TeV per beam to investigate the fundamental elements of matter. The collider is equipped with a collimation system to ensure that potentially destructive halo particles are absorbed before they hit vulnerable elements. Beam-based alignment of the collimators is required to ensure that they are positioned for maximum cleaning efficiency. The alignment procedure relies on feedback from Beam Loss Monitors, and is currently being automated to speed it up. This paper describes a method for automatically selecting a threshold for the beam loss signal during alignment, based on an empirical analysis of collimator alignment data over one year of operation. The results achieved with threshold selection during alignments at 4 TeV are presented.peer-reviewe

Me Upper Sixth Dorm to Mr. Meredith (5 October 1962)

https://egrove.olemiss.edu/mercorr_pro/1985/thumbnail.jp

The Right to Counsel in Mississippi: Evaluation of Adult Felony Trial Level Indigent Defense Services

The Right to Counsel in Mississippi: Evaluation of Adult Felony Trial Level Indigent Defense Service