Social Media Monitoring als Instrument der Kontrolle des Internet-Marketing

Social Media Monitoring (SMM) ist ein aktuelles und bedeutendes Thema im Bereich der Kontrolle des Internet-Marketing, und wird als Instrument der Erfolgskontrolle und zur Analyse von Maßnahmen des Unternehmens eingesetzt, (z.B.: Public Relation-Maßnahmen/Werbekampagnen). Zahlreiche kostenpflichtige und kostenlose Monitoring Tools ermöglichen Unternehmen Gespräche und Diskussionen im Social Web zu analysieren. Aufwendige und teure Studien zu Marktzwecken werden eben durch das schnelle, kostengünstige und gezielte Marktforschungsinstrument ergänzt oder gänzlich aus den Unternehmensbereichen abgelöst. Gegenstand dieser Arbeit ist, das SMM als Instrument der Analyse der Vorgänge in Social Media, in Bezug auf das Internet-Marketing. Diese Arbeit befasst sich mit den Gründen vom Einsatz von Social Media Monitoring, Lösungen und deren Tools. Im Zuge dieser Arbeit werden die verschiedenen Tools vorgestellt. Es wird auch deutlich, dass keine optimale Lösung für ein Unternehmen existiert, denn es gibt kein einheitliches Tool für alle Anwendungsbereiche im Unternehmen

Application of the analytic hierarchy process (AHP) to select the best oil spill cleanup method in marine protected areas for calm sea condition

Oil spill cleanup is a complex and expensive activity. There are several commonly used techniques available today. The paper suggests criteria for the selection of the best available technique that could be employed in case of oil spills in the Mediterranean Sea under specific circumstances, i.e. calm sea and presence of marine protected areas, in order to prevent pollution. Not all the available techniques could be considered. Only three of them could be selected, as these allow the preservation of natural areas, as well as the protection of threatened species and their habitats. The Analytic Hierarchy Process method has been preferred among the great variety in multi-criteria decision making tools for the selection of the best available technique. This is a widespread decision support tool suitable for the selection of the best alternative solution to a particular problem. Twenty professionals with different expertise evaluated, through pair-wise comparisons, the alternative options to choose in a protected area. The selected emergency cleanup technique must be readily available and operational in a short time. The results give a preference to new sorbents, followed closely by the magnetic nanocomposites technique

Genome-Wide Association Studies in Dogs and Humans Identify ADAMTS20 as a Risk Variant for Cleft Lip and Palate

Cleft lip with or without cleft palate (CL/P) is the most commonly occurring craniofacial birth defect. We provide insight into the genetic etiology of this birth defect by performing genome-wide association studies in two species: dogs and humans. In the dog, a genome-wide association study of 7 CL/P cases and 112 controls from the Nova Scotia Duck Tolling Retriever (NSDTR) breed identified a significantly associated region on canine chromosome 27 (unadjusted p=1.1 x 10-13; adjusted p= 2.2 x 10-3). Further analysis in NSDTR families and additional full sibling cases identified a 1.44 Mb homozygous haplotype (chromosome 27: 9.29 – 10.73 Mb) segregating with a more complex phenotype of cleft lip, cleft palate, and syndactyly (CLPS) in 13 cases. Whole-genome sequencing of 3 CLPS cases and 4 controls at 15X coverage led to the discovery of a frameshift mutation within ADAMTS20 (c.1360_1361delAA (p.Lys453Ilefs*3)), which segregated concordant with the phenotype. In a parallel study in humans, a family-based association analysis (DFAM) of 125 CL/P cases, 420 unaffected relatives, and 392 controls from a Guatemalan cohort, identified a suggestive association (rs10785430; p =2.67 x 10-6) with the same gene, ADAMTS20. Sequencing of cases from the Guatemalan cohort was unable to identify a causative mutation within the coding region of ADAMTS20, but four coding variants were found in additional cases of CL/P. In summary, this study provides genetic evidence for a role of ADAMTS20 in CL/P development in dogs and as a candidate gene for CL/P development in humans

Effect Of Exogenous Cholesterol And Dithiothreitol On The Activity Of Human Liver Microsomal Acyl-Coenzyme A:Cholesterol Acyltransferase (ACAT)

esterification of cholesterol with long-chain fatty acyl-CoA derivatives and has been implicated in atherosclerosis and gallstone disease. The effects of exogenous cholesterol and dithiothreitol (DTT) on the ACAT activity of human liver microsomes have been determined. Pre-incubation of microsomes with exogenous cholesterol gave a marked stimulation of activity. Experiments with [3H]cholesterol and [14C]ololeoyl-CoA indicated the time course of equilibration of exogenous with endogenous cholesterol as ACAT substrates, and showed that ACAT activity could be accurately measured using [3H]cholesterol/Tween 80, provising that the concentration of endogenous microsomal cholesterol was also determined. Pre-incubation of liver microsomes for 90 min in the presence of 2 mmol/1 DTT and exogenous cholesterol/Tween 80 resulted in a 60% reduction in ACAT activity, compared with the corresponding activity when DTT was omitted. If microsomes were pre-incubated with DTT prior to the pre-incubation with exogenous cholesterol/Tween 80, and 85–90% reduction in ACAT activity occurred. In contrast, pre-incubation of microsomes with DTT in the absence of exogenous cholesterol/Tween 80 (only endogenous cholesterol present) resulted, initially in a stimulation of ACAT activity; on further pre-incubation, activity returned to control levels. These results indicate that the supply of cholesterol to the enzyme active site is an important factor in ACAT assays in vitro and that DTT has a major effect on this process, suggesting that these factors may be important in controlling ACAT activity in vivo

Macroalgae fouling community as quality element for the evaluation of the ecological status in Vela Luka Bay, Croatia

One year qualitative and quantitative study of communities of three major taxonomic groups has been carried out at test panles placed in the upper infarlittoral zone of coastal area of Vela Luka Bay, Croatia. A list of 44 taxa was recorded. Chaetomorpha sp., Ulva sp., Fosliella farinosa, Sphacelaria cirrosa, Polysiphonia scopulorum were the most frequent dominant taxa. Among 27 algal taxa with noticeable presence only three were classified as ESG (Ecological State Groups) I. Low diversity and species richness together with massive presence of the green algae (as Ulva sp.) and negligible presence of ESG I taxa, may lead to erroneous conclusion that Vela Luka Bay is eutrophicated area. Low values of biomass and R/P (Rhodophyceae by Phaeophyceae ratio) Index together with dominance of Phaeophyta also support conclusion that there is no negative impact of nutrient enrichment on macrophyta fouling community in Vela Luka Bay

Macroalgae fouling community as quality element for the evaluation of the ecological status in Vela Luka Bay, Croatia

One year qualitative and quantitative study of communities of three major taxonomic groups has been carried out at test panles placed in the upper infarlittoral zone of coastal area of Vela Luka Bay, Croatia. A list of 44 taxa was recorded. Chaetomorpha sp., Ulva sp., Fosliella farinosa, Sphacelaria cirrosa, Polysiphonia scopulorum were the most frequent dominant taxa. Among 27 algal taxa with noticeable presence only three were classified as ESG (Ecological State Groups) I. Low diversity and species richness together with massive presence of the green algae (as Ulva sp.) and negligible presence of ESG I taxa, may lead to erroneous conclusion that Vela Luka Bay is eutrophicated area. Low values of biomass and R/P (Rhodophyceae by Phaeophyceae ratio) Index together with dominance of Phaeophyta also support conclusion that there is no negative impact of nutrient enrichment on macrophyta fouling community in Vela Luka Bay

Mechanisms and targets of the modulatory action of S-nitrosoglutathione (GSNO) on inflammatory cytokines expression.

A number of experimental studies has documented that S-nitrosoglutathione (GSNO), the main endogenous low-molecular weight S-nitrosothiol, can exert modulatory effects on inflammatory processes, thus supporting its potential employment in medicine for the treatment of important disease conditions. At molecular level, GSNO effects have been shown to modulate the activity of a series of transcription factors (notably NF-jB, AP-1, CREB and others) as well as other components of signal transduction chains (e.g. IKK-b, caspase 1, calpain and others), resulting in the modulation of several cytokines and chemokines expression (TNFa, IL-1b, IFN-c, IL-4, IL-8, RANTES, MCP-1 and others). Results reported to date are however not univocal, and a single main mechanism of action for the observed anti-inflammatory effects of GSNO has not been identified. Conflicting observations can be explained by differences among the various cell types studies as to the relative abundance of enzymes in charge of GSNO metabolism (GSNO reductase, c-glutamyltransferase, protein disulfide isomerase and others), as well as by variables associated with the individual experimental models employed. Altogether anti-inflammatory properties of GSNO seem however to prevail, and exploration of the therapeutic potential of GSNO and analogues appears therefore warranted