Digital pulse width selection circuit Patent

Development of electric circuit for production of different pulse width signal

Investigation of Metal and Organic Contaminant Distributions and Sedimentation Rates in Backwater Lakes along the Illinois River

Systematic sub-sampling of sediment cores in sections of uniform thickness is necessary in order to evaluate historic changes in sediment quality, to determine the vertical extent of contamination, and to measure sedimentation rates. With these objectives in mind, fourteen sediment cores were collected during March 2002 using the Illinois State Water Survey vibracorer. Concentrations of metals and total organic carbon were measured using standard techniques. Concentrations of chlorinated pesticides, phenolic compounds, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) were measured by gas chromatography/mass spectrometry (GC-MS). The concentrations of chlorinated pesticides, phenolic compounds and polychlorinated biphenyls (PCBs) were below the method detection limit in all sediment samples analyzed. However, there was a wide range in concentrations of polycyclic aromatic hydrocarbons (PAHs) which were detected in all sediment samples. Also, a wide range of metal concentrations was noted in the sediments evaluated. Lower concentrations of metals were found in the upper 0.5 m of sediment but concentrations were elevated at depths ranging from 1.0 m to 1.5 m. Sedimentation rates were estimated using cesium-137 radiometric dating on 14 vibracores. Sedimentation rates range from < 0.1 to 1.9 cm/yr, with an average of 0.9 cm/yr. These rates are comparable to those reported in previous studies.Illinois Sustainable Technology Centerpublished or submitted for publicationis peer reviewe

Luminosity measurement method for the LHC: The detector requirements studies

Absolute normalisation of the LHC measurements with a precision of O(1%) is desirable but beyond the reach of the present LHC detectors. This series of papers proposes and evaluates a measurement method capable to achieve such a precision target. In our earlier paper we have selected the phase-space region where the lepton pair production cross section in pp collisions at the LHC can be controlled with < 1 % precision and is large enough to reach a comparable statistical accuracy of the absolute luminosity measurement on the day-by-day basis. In the present one the performance requirements for a dedicated detector, indispensable to efficiently select events in the proposed phase-space region, are discussed.Comment: 26 pages, 13 figure

SNPsea: an algorithm to identify cell types, tissues and pathways affected by risk loci

Summary: We created a fast, robust and general C++ implementation of a single-nucleotide polymorphism (SNP) set enrichment algorithm to identify cell types, tissues and pathways affected by risk loci. It tests trait-associated genomic loci for enrichment of specificity to conditions (cell types, tissues and pathways). We use a non-parametric statistical approach to compute empirical P-values by comparison with null SNP sets. As a proof of concept, we present novel applications of our method to four sets of genome-wide significant SNPs associated with red blood cell count, multiple sclerosis, celiac disease and HDL cholesterol. Availability and implementation: http://broadinstitute.org/mpg/snpsea Contact: [email protected] Supplementary information: Supplementary data are available at Bioinformatics online

Luminosity Measurement Method for LHC: The theoretical precision and the experimental challenges

This is the first of the series of papers which present a precision method of the day-by-day monitoring of the absolute LHC luminosity. The method is based on the measurement of the rate of coplanar lepton pairs produced in peripheral collisions of the beams' particles. In the present paper we evaluate the modeling precision of the lepton pair production processes in proton-proton collisions, optimize the measurement region to achieve better than 1% accuracy of the predicted rates, and discuss the experimental challenges to filter out the luminosity monitoring lepton pairs at LHC

Gourd\u27geous

Finding a voice to articulate my passion for making utilitarian pottery has been the central focus of my graduate studies. As a ceramic artist, I strive to make work that celebrates clay\u27s tactile qualities, history, environmental responsiveness, and beauty. My research involved investigating different clay processes, fabrication methods, glazes, and contemporary/historical influences. The end result is a body of work that expresses a balanced blending of clay, nature, and history

The immune cell landscape in kidneys of patients with lupus nephritis.

Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control subjects using single-cell RNA sequencing. Our analysis revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses. We found evidence of local activation of B cells correlated with an age-associated B-cell signature and evidence of progressive stages of monocyte differentiation within the kidney. A clear interferon response was observed in most cells. Two chemokine receptors, CXCR4 and CX3CR1, were broadly expressed, implying a potentially central role in cell trafficking. Gene expression of immune cells in urine and kidney was highly correlated, which would suggest that urine might serve as a surrogate for kidney biopsies