Hana-MC:Heading of Arabic News Analysis by Multi-label Classification

Because of the spread of epidemics and diseases in many countries around the world, news consumption from online sources has substantially increased. These news stories written in Arabic are about more than one topic, which is interesting for the multi-label classification paradigm. Furthermore, the recent studies based on multi-label Arabic text classification deal with news articles, which are rather long texts. Thus, we put forward a large dataset of concise Arabic news based basically on the Corona virus, namely Hana-MC, which has been built from various news portals. We conducted a comparative study using several multi-label classification approaches, including algorithm adaptation, problem transformation, and ensemble methods. Experimental results showed that the Ensemble Method RAKELD with the Random Forest base classifier obtained the best accuracy score.</p

Patronage and the Idea of an Urban Bourgeoisie

From the reports of travelers and historians, people learn of the crafting of beautiful rock crystal and metalwork objects in the Cairo bazaar and, during the later Mamluk period, of beautiful gilded and enameled glass being produced in commercial areas of Aleppo and Damascus. Given the diverse subject matter of the manuscripts, people may speak of a patronage base allying the intelligentsia to the merchant class within a more broadly conceived bourgeoisie, one whose interests and aesthetic preferences, as compared with those of the court, might be productively investigated through such illustrated manuscripts. One of the frontispieces of a wonderful illustrated manuscript contains clearly Christian iconographical elements, and among the Christian community of Iraq and Syria, people encounter ample evidence for the patronage and production of metalwork, ceramics, and gilded and enameled glass as well as manuscripts

Early and reversible changes to the hippocampal proteome in mice on a high-fat diet

Funding LMW, FMC, CG, ACM and C-DM were funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS). FHM was supported by an EASTBIO DTP BBSRC studentship. DS was supported by a SULSA studentship.Peer reviewedPublisher PD

Label-based meta-analysis of functional brain dysconnectivity across mood and psychotic disorders.

peer reviewed[en] BACKGROUND: Resting-state functional magnetic resonance imaging (rsfMRI) studies have revealed patterns of functional brain dysconnectivity in psychiatric disorders such as major depression disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ). Although these disorders have been mostly studied in isolation, there is mounting evidence of shared neurobiological alterations across them. METHODS: To uncover the nature of the relatedness between these psychiatric disorders, we conducted an innovative meta-analysis of dysconnectivity findings reported separately in MDD, BD and SZ. Rather than relying on a classical voxel level coordinate-based approach, our procedure extracted relevant neuroanatomical labels from text data and examined findings at the whole brain network level. Data were drawn from 428 rsfMRI studies investigating MDD (158 studies, 7429 patients/7414 controls), BD (81 studies, 3330 patients/4096 patients) and/or SZ (223 studies, 11,168 patients/11,754 controls). Permutation testing revealed commonalities and differences in hypoconnectivity and hyperconnectivity patterns across disorders. RESULTS: Hypoconnectivity and hyperconnectivity patterns of higher-order cognitive (default-mode, fronto-parietal, cingulo-opercular) networks were similarly observed across the three disorders. By contrast, dysconnectivity of lower-order (somatomotor, visual, auditory) networks in some cases differed between disorders, notably dissociating SZ from BD and MDD. CONCLUSIONS: Findings suggest that functional brain dysconnectivity of higher-order cognitive networks is largely transdiagnostic in nature while that of lower-order networks may best discriminate between mood and psychotic disorders, thus emphasizing the relevance of motor and sensory networks to psychiatric neuroscience

The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid

The biogenesis and accumulation of the beta amyloid protein (Aβ) is a key event in the cascade of oxidative and inflammatory processes that characterises Alzheimer’s disease. The presenilins and its interacting proteins play a pivotal role in the generation of Aβ from the amyloid precursor protein (APP). In particular, three proteins (nicastrin, aph-1 and pen-2) interact with presenilins to form a large multi-subunit enzymatic complex (γ-secretase) that cleaves APP to generate Aβ. Reconstitution studies in yeast and insect cells have provided strong evidence that these four proteins are the major components of the γ-secretase enzyme. Current research is directed at elucidating the roles that each of these protein play in the function of this enzyme. In addition, a number of presenilin interacting proteins that are not components of γ-secretase play important roles in modulating Aβ production. This review will discuss the components of the γ-secretase complex and the role of presenilin interacting proteins on γ-secretase activity

Obésité induite par un régime riche en lipides (HFD) et effet protecteur d'un extrait polyphénolique de raisin (GSSE) : approche protéomique

The effects of GSSE (Grape seed and skin extract) extracted from grapes particularly rich in antioxidants have been studied to prevent metabolic and cardiovascular disorders related to obesity. Obesity is characterized by an ectopic accumulation of fat in non-adipose tissues such as the brain. This cerebral lipotoxicity induces chronic inflammation of the brain. In this work, using quantitative proteomic analysis, biochemical and bio-informatic tools allows us to identify actors of metabolic and biological pathways that were disregulated in brain of experimentally-induced obese rats and corrected by GSSE treatment. While our data are consistent with previous findings of obesity-induced brain lipotoxicity, such as enhancement of proteins belonging to the OXPHOS and calcium pathways, they also unveiled novel pathways including the up-regulation of HIF-signaling pathway in HFD brains. In the same context, GSSE abrogated HFD-induced signaling pathway elevation either by modulating several proteins or by inducing some others that were not affected by HFDLes effets du GSSE (Grape seed and skin extract), extrait de raisin particulièrement riche en antioxydants, ont été étudiés pour prévenir les troubles métaboliques et cardiovasculaires liés à l’obésité. L’obésité est caractérisée par une accumulation ectopique de graisse dans les tissus non adipeux tels que le cerveau. Cette lipotoxicité cérébrale induit une inflammation chronique au niveau du cerveau. Dans ce présent travail, nous avons décrit l’effet anti-obésité du GSSE dans un modèle expérimental d’obésité induite par un régime alimentaire à haute teneur en graisses (HFD) tout en mettant l’accent sur le stress oxydant ainsi que le dysfonctionnement métabolique du cerveau qui n’est pas organe cible de l’obésité. Grâce à ce travail, nous avons développé une approche protéomique quantitative Nano LCMS/MS Label free afin d’identifier les biomarqueurs liés au traitement riche en lipides (HFD) et à la protection apportée au cerveau par le GSSE. Pour ce faire, on a eu recours à un modèle animal afin de mieux comprendre les voies métaboliques potentielles altérées par l’obésité et la protection apportée par le GSSE. Plusieurs protéines ont été identifiées et quantifiées en comparant le protéome cérébral total chez les rats dans les différentes conditions de traitements. On a eu recours à des outils de bioinformatique qui nous ont permis de conclure que ces protéines significativement différenciées sont principalement liées à la voie de la phosphorylation oxydative, de la glycolyse / néoglucogenèse et celle de la signalisation du calcium. Ces résultats ont été confirmés par la mesure de quelques activités enzymatiques métaboliques. Fait intéressant, qu’elles soient sous ou surexprimées par le traitement du HFD, le GSSE corrige l’effet délétère apporté aux différentes protéines et enzymes suite au traitement du HFD. D’autres voies métaboliques cérébrales ont été induites par le GSSE telle que le « HIF signaling pathway ». Ces résultats nous permettent de fournir un élan pour l’investigation thérapeutique du GSSE contre différents désordres métaboliques

La sécurité définie par le logiciel pour la virtualisation des fonctions réseaux

Network Function Virtualization (NFV) technology has been proposed to improve the deployment flexibility and cost effectiveness of network services and allows for better information sharing between their components. Despite the aforementioned benefits, existing NFV infrastructures suffer from several security issues. The objective of this thesis is to improve the security of NFV services. To achieve this goal, we proposed a number of contributions. First, we studied the existing and potential security problems and threats in NFV infrastructures. Then, we classified them according to the components that are affected by these threats. Then, we studied the different security mechanisms that can be used to reduce these risks. This study allowed us to realize that the deployment of access control policies at the NFV service level can mitigate several security issues. This realization led us to examine existing solutions for deploying access control policies in NFV infrastructures. Third, we provide a comprehensive comparative overview of existing solutions based on several properties, including the adversary model considered, effectiveness, veracity, and optimality.La technologie NFV (Network Function Virtualization) a été proposé pour améliorer la flexibilité du déploiement et la rentabilité des services de réseau et elle permet un meilleur partage des informations entre leurs composants. Malgré les avantages susmentionnés, les infrastructures NFV existantes souffrent de plusieurs problèmes de sécurité. L’objectif de cette thèse est d’améliorer la sécurité des services NFVs. Pour atteindre cet objectif, nous avons proposé un certain nombre de contributions. Tout d’abord, nous avons étudié les problèmes et les menaces de sécurité existants et potentiels dans les infrastructures NFVs. Ensuite, nous les avons classés en fonction des composants qui sont affectés par ces menaces. Puis, nous avons étudié les différents mécanismes de sécurité qui peuvent être utilisés pour réduire ces risques. Cette étude nous a permis de réaliser que le déploiement des politiques de contrôle d’accès au niveau des services NFV permet d’atténuer plusieurs problèmes de sécurité. Ce constat nous a conduit à examiner les solutions existantes pour le déploiement des politiques de contrôle d’accès dans les infrastructures NFV. Troisièmement, nous fournissons un aperçu comparatif complet des solutions existantes en se basant sur plusieurs propriétés, y compris le modèle d’adversaire considéré, l’efficacité, la véracité et l’optimalité