Determining the phases alpha and gamma from time-dependent CP violation in B0 decays to rho(omega) + pseudoscalar

A method is proposed for the determination of the unitarity angle alpha through tree penguin interference. The modes needed would be of the form B0/B0-bar -> rho0 M and B0/B0-bar -> omega M where M is spin-0 uu-bar/dd-bar meson, for instance M=pi0, eta, eta',a0 or f0. An analogous method can also determine gamma using M=KS or K_L. The validity of the theoretical approximations used may be tested by over determining alpha with several modes. If two or more modes are used, the determination has a four-fold ambiguity but additional information from pure penguin decays or theoretical estimates may be used to reduce the ambiguity to alpha, alpha+pi. The method as applied to determining gamma is probably less promising.Comment: 17 pages, 2 figures; Small change with respect to the references and a postscript bug in the figures fixe

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function : a report from the COGENT consortium

CORRIGENDUM Molecular Psychiatry (2017) 22, 1651–1652 http://www.nature.com/articles/mp2017197.pdfThe complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (similar to 8M single-nucleotide polymorphisms (SNP) with minor allele frequency >= 1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (PPeer reviewe

A realistic utopia?: Nancy Fraser, cosmopolitanism and the making of a just world order

Nearly two decades after the end of the Cold War, academics, policy makers and commentators continue to be puzzled by the shape, form and content of contemporary world politics. The fluidity of the post-Cold War era has seen the elevation of largely functional explanations for why things are to a more transcendent set of ideas about how social relations can be made afresh. This shift from ideology to utopia is no idle problem, for what it tends to generate are images which often lie outside historical experience and time and place specificities. This article is an attempt to provide a corrective to at least parts of this malady by carrying out a Zeitdiagnose which questions some of the taken-for-granted assumptions about the current period, in particular the schema offered by the prominent cosmopolitan thinker, Nancy Fraser. The article looks in detail at the historical basis of Fraser's current work, comparing it both to similar visions prevalent in the inter-war years and to contemporary programmes based on the theory of the democratic peace and the policy of democracy promotion. The article develops a construct – realistic utopias – which aims to build from history to mid-range abstractions rather than from general abstractions to events on the ground. As a result, it is argued, a more developed link can be made between theory and practice, abstraction and history, normative project and institutional reality