Les ruses du roman-photo contemporain

L'étroitesse thématique et l'indigence de réalisation du photo-roman traditionnel ne sont pas aisément explicables: évoquer l'impact des exigences économiques de son industrie ou les caractéristiques sociologiques de son lectorat a trop longtemps étouffé toute réflexion sérieuse à son propos. Des oeuvres contemporaines, par leurs explorations multiples et leur travail su rles conditions mêmes d'expression du photo-roman, obligent dorénavant à déplacer la réflexion des seuls niveaux esthétique ou thématique aux fondements matériologiques du médium. Dans la ligne des travaux de Jan Baetens, cet article parcourt un certain nombre des stratégies de renouvellement à l'oeuvre dans ces productions récentes.It is not easy to explain the traditional photographic novel's poverty of inspiration and formal treatment.Invoking the impact of economic constraints and the sociological characteristics of its readership has for too lon thwarted a searching reflection on the subject. In focusing on the expressive limitations of the photo novel, some contemporary critiques force us to shift our gaze from the aesthetic or thematic, to the material aspects of the medium. Following Jan Baetens' lead, this article retraces a number of strategies at work in recent exemplars of the genre

Microlecture et macro-enjeux de la narration graphique. L’arpentage de Jan Baetens

Dans le domaine de la narration graphique comme ailleurs, la crise généralisée des pratiques culturelles aura souvent stimulé le redéploiement de l’appareil théorique. Depuis quelques années, les travaux de Jan Baetens s’attachent notamment à décrire la complexité du dispositif propre aux récits en images. Privilégiant la méthode des microlectures, son dernier ouvrage, Formes et politique de la bande dessinée, analyse finement certains des paramètres expressifs (couleur, dynamique icono-linguistique, enjeu narratif) tout en s’interrogeant sur les conditions de production et la mise en circulation des oeuvres. Au-delà du domaine de la narration graphique, les perspectives évoquées constituent un outil précieux pour revoir le champ culturel dans son ensemble.In the field of “ visual and graphic narratives ”, as in other arts, the recent crisis in cultural practices has stimulated a new vitality in theoretical thinking. Jan Baetens has proposed, these last few years, in depth analyses of the parametric ressources of graphic narratives. In his last essay, Forme et politique de la bande dessinée, he has described meticulously aspects of these ressources (color, iconic and linguistic codes, the impact of the narrative form), as well as the conditions of production and circulation of these graphic works. His reflexions constitue a wonderful point of view, from which to question the cultural field as a whole

LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.

The blood-brain barrier (BBB) is a term used to describe the unique properties of central nervous system (CNS) blood vessels. One important BBB property is the formation of a paracellular barrier made by tight junctions (TJs) between CNS endothelial cells (ECs). Here, we show that Lipolysis-stimulated lipoprotein receptor (LSR), a component of paracellular junctions at points in which three cell membranes meet, is greatly enriched in CNS ECs compared with ECs in other nonneural tissues. We demonstrate that LSR is specifically expressed at tricellular junctions and that its expression correlates with the onset of BBB formation during embryogenesis. We further demonstrate that the BBB does not seal during embryogenesis in Lsr knockout mice with a leakage to small molecules. Finally, in mouse models in which BBB was disrupted, including an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis and a middle cerebral artery occlusion (MCAO) model of stroke, LSR was down-regulated, linking loss of LSR and pathological BBB leakage

A ‘warm path’ for Gulf Stream–troposphere interactions

Warm advection by the Gulf Stream creates a characteristic ‘tongue’ of warm water leaving a strong imprint on the sea surface temperature (SST) distribution in the western North Atlantic. This study aims at quantifying the climatological impact of this feature on cyclones travelling across this region in winter using a combination of reanalysis data and numerical experiments. It is suggested that the Gulf Stream ‘warm tongue’ is conducive to enhanced upward motion in cyclones because (i) it helps maintain a high equivalent potential temperature of air parcels at low levels which favors deep ascent in the warm conveyor belt of cyclones and (ii) because the large SST gradients to the north of the warm tongue drive a thermally direct circulation reinforcing and, possibly, destabilizing, the transverse circulation embedded in cyclones. This hypothesis is confirmed by comparing simulations at 12 km resolution from the Met Office Unified Model forced with realistic SST distribution to simulations with an SST distribution from which the Gulf Stream warm tongue was artificially removed or made colder by . It is also supported by a dynamical diagnostic applied to the ERA interim data-set over the wintertime period (1979–2012). The mechanism of oceanic forcing highlighted in this study is associated with near thermal equilibration of low level air masses with SST in the warm sector of cyclones passing over the Gulf Stream warm tongue, which is in sharp contrast to what occurs in their cold sector. It is suggested that this ‘warm path’ for the climatic impact of the Gulf Stream on the North Atlantic storm-track is not currently represented in climate models because of their coarse horizontal resolution

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module.

Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). We present a resource to understand the molecular mechanisms that regulate BBB function in health and dysfunction during disease. Using endothelial cell enrichment and RNA sequencing, we analyzed the gene expression of endothelial cells in mice, comparing brain endothelial cells with peripheral endothelial cells. We also assessed the regulation of CNS endothelial gene expression in models of stroke, multiple sclerosis, traumatic brain injury and seizure, each having profound BBB disruption. We found that although each is caused by a distinct trigger, they exhibit strikingly similar endothelial gene expression changes during BBB disruption, comprising a core BBB dysfunction module that shifts the CNS endothelial cells into a peripheral endothelial cell-like state. The identification of a common pathway for BBB dysfunction suggests that targeting therapeutic agents to limit it may be effective across multiple neurological disorders

Hierarchical coupled routing-charging model of electric vehicles, stations and grid operators

Electric Vehicles' (EVs) growing number has various consequences, from reducing greenhouse gas emissions and local pollution to altering traffic congestion and electricity consumption. More specifically, decisions of operators from both the transportation and the electrical systems are coupled due to EVs' decisions. Thus, decision-making requires a model of several interdependent operators and of EVs' both driving and charging behaviors. Such a model is suggested for the electrical system in the context of commuting, which has a typical trilevel structure. At the lower level of the model, a congestion game between different types of vehicles gives which driving paths and charging stations (or hubs) commuters choose, depending on travel duration and consumption costs. At the middle level, a Charging Service Operator sets the charging prices at the hubs to maximize the difference between EV charging revenues and electricity supplying costs, which are decided by the Electrical Network Operator at the upper level of the model, whose goal is to reduce grid costs. This trilevel optimization problem is solved using an optimistic iterative bilevel algorithm and simulated annealing. The sensitivity of this trilevel model to exogenous parameters such as the EV penetration and an incentive from a transportation operator is illustrated on realistic urban networks.Comment: 12 pages, 9 figures, published in IEEE Transactions on Smart Gri

Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth.

BACKGROUND: It is well established that low birth weight and accelerated postnatal growth increase the risk of liver dysfunction in later life. However, molecular mechanisms underlying such developmental programming are not well characterized, and potential intervention strategies are poorly defined. OBJECTIVES: We tested the hypotheses that poor maternal nutrition and accelerated postnatal growth would lead to increased hepatic fibrosis (a pathological marker of liver dysfunction) and that postnatal supplementation with the antioxidant coenzyme Q10 (CoQ10) would prevent this programmed phenotype. DESIGN: A rat model of maternal protein restriction was used to generate low-birth-weight offspring that underwent accelerated postnatal growth (termed "recuperated"). These were compared with control rats. Offspring were weaned onto standard feed pellets with or without dietary CoQ10 (1 mg/kg body weight per day) supplementation. At 12 mo, hepatic fibrosis, indexes of inflammation, oxidative stress, and insulin signaling were measured by histology, Western blot, ELISA, and reverse transcriptase-polymerase chain reaction. RESULTS: Hepatic collagen deposition (diameter of deposit) was greater in recuperated offspring (mean ± SEM: 12 ± 2 μm) than in controls (5 ± 0.5 μm) (P < 0.001). This was associated with greater inflammation (interleukin 6: 38% ± 24% increase; P < 0.05; tumor necrosis factor α: 64% ± 24% increase; P < 0.05), lipid peroxidation (4-hydroxynonenal, measured by ELISA: 0.30 ± 0.02 compared with 0.19 ± 0.05 μg/mL per μg protein; P < 0.05), and hyperinsulinemia (P < 0.05). CoQ10 supplementation increased (P < 0.01) hepatic CoQ10 concentrations and ameliorated liver fibrosis (P < 0.001), inflammation (P < 0.001), some measures of oxidative stress (P < 0.001), and hyperinsulinemia (P < 0.01). CONCLUSIONS: Suboptimal in utero nutrition combined with accelerated postnatal catch-up growth caused more hepatic fibrosis in adulthood, which was associated with higher indexes of oxidative stress and inflammation and hyperinsulinemia. CoQ10 supplementation prevented liver fibrosis accompanied by downregulation of oxidative stress, inflammation, and hyperinsulinemia.This work was supported by The British Heart Foundation [PG/09/037/27387, FS/09/029/27902]; and The Medical Research Council [MC_UU_12012/4]. Serum analysis was performed by The Wellcome Trust Supported Cambridge Mouse Laboratory, UK. SEO is a member of the MRC Metabolic Diseases Unit. IPH is supported by the Department of Health’s NIHR Biomedical Research Centers funding scheme at UCLH/UCL.This is the final version of the article. It first appeared from the American Society for Nutrition via http://dx.doi.org/10.3945/ajcn.115.11983