Tomography: mathematical aspects and applications

In this article we present a review of the Radon transform and the instability of the tomographic reconstruction process. We show some new mathematical results in tomography obtained by a variational formulation of the reconstruction problem based on the minimization of a Mumford-Shah type functional. Finally, we exhibit a physical interpretation of this new technique and discuss some possible generalizations.Comment: 11 pages, 5 figure

Ecological correlation between diabetes hospitalizations and fine particulate matter in Italian provinces

Background: Exposure to particulate matter has been associated with increased risk of cardiovascular and respiratory diseases. We evaluated the ecological correlation between standardized hospital discharges with diabetes in Italian provinces and fine particulate matter (PM2.5) adjusting for common risk factors, socioeconomic factors and differences in hospitalization appropriateness. Methods: We used cross sectional data aggregated at the province level and available from official institutional databases for years 2008–2010. Covariates included prevalence of adult overweight, obese, smokers, physically inactive, education and income (as average gross domestic product per person, GDP). We reduced the number of covariates to a smaller number of factors for the subsequent statistical model by extracting meaningful components using principal component analysis (PCA). Log-linear multiple regression analysis was used to model diabetes hospital discharges with PCA components and PM2.5 levels and hospitalization appropriateness for men and women. Results: The first PCA components for both men and women were characterized by larger loadings of risk factors (obesity, overweight, physical inactivity, cigarette smoking) and lower socioeconomic factors (educational level and mean GDP). Diabetes hospitalization increases with the first PCA component and decreases with the index of hospitalization appropriateness. In fully adjusted models, diabetes hospitalizations increase with increasing annual PM2.5 concentrations, with a rise of 3.5 % (1.3 %–5.6 %) for men and of 4.0 % (1.5 %-6.4 %) for women per unit of PM2.5 increase. Conclusions: We found a significant ecological relationship between sex and age standardised hospital discharge with diabetes as principle diagnosis and mean annual PM2.5 concentrations in Italian provinces, once that covariates have been accounted for. The relationship was robust to different means of estimating PM2.5 exposure. A large portion of the variance of diabetes hospitalizations was linked to differences of hospital care appropriateness between Italian regions and this variable should routinely be included in ecological analyses of hospitalizations

Awareness towards Chikungunya virus infection risk by general practitioners in Rome: a questionnaire based survey before the 2017 outbreak

Autochthonous cases of Chikungunya (CHIKV) have been recently detected in Rome. A survey was conduct- ed prior to the 2017 outbreak to assess knowledge, attitude, and practices towards CHIKV infections on 103 randomly selected general practitioners (GPs), practicing in the centre of Rome. Only 24.3% were aware of CHIKV and completed the interview. Among completers, the knowledge of basic elements of CHIKV in- fection was insufficient. Only two thirds of them were able to identify possible CHIKV cases in hypothetical clinical scenarios presented by the interviewer. Our study highlights the need to improve GP knowledge to- wards CHIKV, as a necessary step to establish an efficacious epidemic surveillance

Efficacy of acoustic waves in preventing Streptococcus mutans adhesion on dental unit water line

Background: nei riuniti odontoiatrici, la qualità dell'acqua utilizzata per la refrigerazione e il risciacquo di manipoli, siringhe e altri componenti è un aspetto di notevole importanza sanitaria. L'acqua attraversa questi dispositivi mediante un circuito interconnesso di tubi di piccole dimensioni (circa 2 mm di diametro), denominato “dental unit water line” (DUWL). I DUWL possono essere fortemente colonizzati da varie specie batteriche sia in fase planctonica, che adesi o organizzati in biofilm, rappresentando una potenziale causa di infezione, non solo per i professionisti che usano abitualmente questi dispositivi, ma anche per pazienti occasionali, in particolare per i pazienti immunocompromessi. La contaminazione dei DUWL può essere prevenuta o ridotta con l'uso dei disinfettanti, ma l'eradicazione dei microrganismi adesi alle superfici interne dei DUWL o organizzati in forma di biofilm, è una sfida assai più complessa e spesso i normali metodi di disinfezione non sono pienamente efficaci. Inoltre, in ambito odontoiatrico, i disinfettanti utilizzati abitualmente per disinfettare i DUWL possono alterare la capacità adesiva del materiale utilizzato nella pratica restaurativa. Obiettivi: individuare una strategia innovativa, in grado di contrastare l'adesione batterica alle superfici dei DUWL mediante un approccio di tipo fisico, che sia più efficace nel superare il problema della contaminazione dei DUWL e ridurre il rischio di infezione rispetto ai normali metodi già in uso. A tal fine, fra le molte specie batteriche potenzialmente riscontrabili nei circuiti idrici odontoiatrici, si è deciso di avviare questo studio pilota utilizzando la specie batterica patogena S. mutans, per il suo indubbio interesse in ambito odontoiatrico e per la sua spiccata capacità di aderire e persistere su superfici inerti. Metodi: utilizzo di onde acustiche elastiche ad alta energia nel contrastare l'adesione di Streptococcus mutans alle pareti interne di un circuito idrico sperimentale riproducente un DUWL. Per evidenziare l’efficacia delle onde acustiche anche in condizioni estreme, è stata utilizzata un’elevata carica contaminante di S. mutans. Risultati: Si osserva una significativa riduzione dei batteri adesi soggetti a trattamento con onde acustiche rispetto al controllo (P = 0,003)

Relationships between Pressures, Chemical Status, and Biological Quality Elements. Analysis of the Current Knowledge Gaps for the Implementation of the Water Framework Directive

The general objective of the REBECCA project1 is to provide relevant scientific support for the implementation of the Water Framework Directive (WFD). The two specific aims of the project are, firstly, to establish links between ecological status of surface waters and physico-chemical quality elements and pressures from different sources, and, secondly, to develop and validate tools that member states can use in the process of classification, in the design of their monitoring programs, and in the design of measures in accordance with the requirements of the WFD. Historically, there has been great success in maintaining and improving the quality of surface waters by developing an understanding of the links between anthropogenic pressures (e.g. water abstraction, agriculture, and effluent discharges) and the chemical status of waters, although there remain many challenges in reliably designing and implementing the necessary programs of measures. Our present understanding of the link between chemical properties and ecological state, while good in some instances, is generally not adequate to support management intervention against ecological objectives. In this report we review and identify information gaps in our knowledge on relations between pressures, chemical and ecological status for the major pressures types and biological quality elements. We also give an overview of the chemical parameters that are used to determine the ecological status of water body types and of the biological indicators currently applied and/or potentially applicable as classification parameters for inland and coastal waters. This gap-analysis is needed to 1) identify the key areas of further work within the REBECCA project and 2) to identify the areas where further experimental or monitoring work would be needed (beyond the scope of REBECCA), due to lack of data or quantitative understanding of the functional relationships between chemical status and biological quality indicators. This report should help in focusing the on-going WFD intercalibration process in 2005-6. In particular it should provide insights on which biological and pressure parameters should be selected and which data there would be available to illustrate the degradation of the biological quality with respect of pressure gradients.JRC.H.5-Rural, water and ecosystem resource

Segmentation of image: by variational methods: A constructive approach

Sin resume

Ecological Quality Ratios for Ecological Quality Assessment in Inland and Marine Waters

This report addresses the issue: What is a WFD compliant assessment method? This is done by focusing on the concept of the Ecological Quality Ratio (EQR). The EQR incorporates the key WFD requirements for ecological classification: typology, reference conditions, and class boundary setting. The Deliverable is targeted both to the policy makers and competent authorities implementing the Water Framework Directive and the scientists supporting them with their specific knowledge. The Classification Guidance separates three levels in the biological assessment: the parameter level, the quality element level, and the status classification. The main conclusion is that the WFD requires classification of water bodies at the quality element level, and that the worst of the relevant quality elements determines the final classification (the “one out, all out” principle). How the different parameters within a quality element are combined is not prescribed; this can either be done by combining them in a multimetric index, or in any other way. WFD- compliance criteria for assessment methods include reference conditions setting, definition of quality classes, and intercalibration of those boundaries. Those are currently addressed in the WFD intercalibration exercise, with a strong focus on specific quality elements and pressures. It is expected that the remaining quality elements and pressures will be addressed in the next couple of years, and that there will be a tendency from very specific, single-parameter, pressure-specific methods towards more general multimetric approaches. Quantification of EQR uncertainty should be implemented in future assessment programs. Software like starbugs (http://www.eu-star.at/) may help in the assessment of EQR uncertainty and provides a first attempt into this direction. It should be remarked that the analysis of uncertainty of EQR classification of a given site resulting from the use of a specific assessment scheme does not reveal the (unknown) real quality class of that site. If the EQR assessment outcome can be incorporated into a modelling framework, uncertainties may be assessed through careful evaluation of model predictions.JRC.H.5-Rural, water and ecosystem resource

The Ebola virus disease outbreak in Tonkolili district, Sierra Leone: a retrospective analysis of the Viral Haemorrhagic Fever surveillance system, July 2014–June 2015

In Sierra Leone, the Ebola virus disease (EVD) outbreak occurred with substantial differences between districts with someone even not affected. To monitor the epidemic, a community event-based surveillance system was set up, collecting data into the Viral Haemorrhagic Fever (VHF) database. We analysed the VHF database of Tonkolili district to describe the epi- demiology of the EVD outbreak during July 2014–June 2015 (data availability). Multivariable analysis was used to identify risk factors for EVD, fatal EVD and barriers to healthcare access, by comparing EVD-positive vs. EVD-negative cases. Key-performance indicators for EVD response were also measured. Overall, 454 EVD-positive cases were reported. At multivariable analysis, the odds of EVD was higher among those reporting contacts with an EVD-positive/ suspected case (odds ratio (OR) 2.47; 95% confidence interval (CI) 2.44–2.50; P < 0.01) and those attending funeral (OR 1.02; 95% CI 1.01–1.04; P < 0.01). EVD cases from Kunike chief- dom had a lower odds of death (OR 0.22; 95% CI 0.08–0.44; P < 0.01) and were also more likely to be hospitalised (OR 2.34; 95% CI 1.23–4.57; P < 0.05). Only 25.1% of alerts were gen- erated within 1 day from symptom onset. EVD preparedness and response plans for Tonkolili should include social-mobilisation activities targeting Ebola/knowledge-attitudes-practice dur- ing funeral attendance, to avoid contact with suspected cases and to increase awareness on EVD symptoms, in order to reduce delays between symptom onset to alert generation and consequently improve the outbreak-response promptness