Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody

We have utilized a high-diversity phage display library to engineer antibody fragments (Fabs) that can modulate the activity of the enzyme isocitrate dehydrogenase 1 (IDH1). We show that a conformation-specific Fab can reactivate an IDH1 mutant associated with brain tumors. The results show that this strategy is a first step towards developing "activator drugs" for a large number of genetic disorders where mutations have disrupted protein function

Some studies on k essence Lagrangian

K-essence Lagrangian is studied in the context of an early universe epoch when time is very small. Equation of state parameter as well as deceleration parameter , indicates an accelerated expansion of the universe at an early epoch of time driven by negative pressure generated by dark energy.Comment: 8 pages. Submitted to International Journal of Innovative research in Physic

A comparative study on Multilingualism & Mother Tongue Education

Abstract ?If we teach todaythe way we taught yesterday, we rob our children of tomorrow.? by John Dewey. Children areborn with an innate language faculty. We know fromour everyday experiences that most children, evenbefore they start their schooling, internalise an extremelycomplex and rule-governed system called language, andpossess full linguistic capabilities. In many cases, childrencome to school with two or three languages already inplace at the oral-aural level. They are able to use theselanguages not only accurately but also appropriately.Even differently talented children who do not use thespoken languages develop equally complex alternativesign and symbol systems for expression andcommunication