On the "renormalization" transformations induced by cycles of expansion and contraction in causal set cosmology

We study the ``renormalization group action'' induced by cycles of cosmic expansion and contraction, within the context of a family of stochastic dynamical laws for causal sets derived earlier. We find a line of fixed points corresponding to the dynamics of transitive percolation, and we prove that there exist no other fixed points and no cycles of length two or more. We also identify an extensive ``basin of attraction'' of the fixed points but find that it does not exhaust the full parameter space. Nevertheless, we conjecture that every trajectory is drawn toward the fixed point set in a suitably weakened sense.Comment: 22 pages, 1 firgure, submitted to Phys. Rev.

On the absence of homogeneous scalar unitary cellular automata

Failure to find homogeneous scalar unitary cellular automata (CA) in one dimension led to consideration of only ``approximately unitary'' CA---which motivated our recent proof of a No-go Lemma in one dimension. In this note we extend the one dimensional result to prove the absence of nontrivial homogeneous scalar unitary CA on Euclidean lattices in any dimension.Comment: 7 pages, plain TeX, 3 PostScript figures included with epsf.tex (ignore the under/overfull \vbox error messages); minor changes (including title wording) in response to referee suggestions, also updated references; to appear in Phys. Lett.

Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.

BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined. Previous studies suggest spinal cord p38 mitogen-activated protein (MAP) kinase and cytokines participate in nociceptive behavior. We therefore determined whether these pathways also regulate peripheral inflammation in rat adjuvant arthritis, which is a model of rheumatoid arthritis.Methods and findingsSelective blockade of spinal cord p38 MAP kinase by administering the p38 inhibitor SB203580 via intrathecal (IT) catheters in rats with adjuvant arthritis markedly suppressed paw swelling, inhibited synovial inflammation, and decreased radiographic evidence of joint destruction. The same dose of SB203580 delivered systemically had no effect, indicating that the effect was mediated by local concentrations in the neural compartment. Evaluation of articular gene expression by quantitative real-time PCR showed that spinal p38 inhibition markedly decreased synovial interleukin-1 and -6 and matrix metalloproteinase (MMP3) gene expression. Activation of p38 required tumor necrosis factor alpha (TNFalpha) in the nervous system because IT etanercept (a TNF inhibitor) given during adjuvant arthritis blocked spinal p38 phosphorylation and reduced clinical signs of adjuvant arthritis.ConclusionsThese data suggest that peripheral inflammation is sensed by the central nervous system (CNS), which subsequently activates stress-induced kinases in the spinal cord via a TNFalpha-dependent mechanism. Intracellular p38 MAP kinase signaling processes this information and profoundly modulates somatic inflammatory responses. Characterization of this mechanism could have clinical and basic research implications by supporting development of new treatments for arthritis and clarifying how the CNS regulates peripheral immune responses

Non-perturbative Lorentzian Quantum Gravity, Causality and Topology Change

We formulate a non-perturbative lattice model of two-dimensional Lorentzian quantum gravity by performing the path integral over geometries with a causal structure. The model can be solved exactly at the discretized level. Its continuum limit coincides with the theory obtained by quantizing 2d continuum gravity in proper-time gauge, but it disagrees with 2d gravity defined via matrix models or Liouville theory. By allowing topology change of the compact spatial slices (i.e. baby universe creation), one obtains agreement with the matrix models and Liouville theory.Comment: 30 pages, 5 figures, Latex, uses psfig.st

Spatial Hypersurfaces in Causal Set Cosmology

Within the causal set approach to quantum gravity, a discrete analog of a spacelike region is a set of unrelated elements, or an antichain. In the continuum approximation of the theory, a moment-of-time hypersurface is well represented by an inextendible antichain. We construct a richer structure corresponding to a thickening of this antichain containing non-trivial geometric and topological information. We find that covariant observables can be associated with such thickened antichains and transitions between them, in classical stochastic growth models of causal sets. This construction highlights the difference between the covariant measure on causal set cosmology and the standard sum-over-histories approach: the measure is assigned to completed histories rather than to histories on a restricted spacetime region. The resulting re-phrasing of the sum-over-histories may be fruitful in other approaches to quantum gravity.Comment: Revtex, 12 pages, 2 figure

A Bell Inequality Analog in Quantum Measure Theory

One obtains Bell's inequalities if one posits a hypothetical joint probability distribution, or {\it measure}, whose marginals yield the probabilities produced by the spin measurements in question. The existence of a joint measure is in turn equivalent to a certain causality condition known as ``screening off''. We show that if one assumes, more generally, a joint {\it quantal measure}, or ``decoherence functional'', one obtains instead an analogous inequality weaker by a factor of $\sqrt{2}$. The proof of this ``Tsirel'son inequality'' is geometrical and rests on the possibility of associating a Hilbert space to any strongly positive quantal measure. These results lead both to a {\it question}: ``Does a joint measure follow from some quantal analog of `screening off'?'', and to the {\it observation} that non-contextual hidden variables are viable in histories-based quantum mechanics, even if they are excluded classically.Comment: 38 pages, TeX. Several changes and added comments to bring out the meaning more clearly. Minor rewording and extra acknowledgements, now closer to published versio

A numerical study of the correspondence between paths in a causal set and geodesics in the continuum

This paper presents the results of a computational study related to the path-geodesic correspondence in causal sets. For intervals in flat spacetimes, and in selected curved spacetimes, we present evidence that the longest maximal chains (the longest paths) in the corresponding causal set intervals statistically approach the geodesic for that interval in the appropriate continuum limit.Comment: To the celebration of the 60th birthday of Rafael D. Sorki

Phase coexistence and torpid mixing in the 3-coloring model on Z^d

We show that for all sufficiently large d, the uniform proper 3-coloring model (in physics called the 3-state antiferromagnetic Potts model at zero temperature) on Z^d admits multiple maximal-entropy Gibbs measures. This is a consequence of the following combinatorial result: if a proper 3-coloring is chosen uniformly from a box in Z^d, conditioned on color 0 being given to all the vertices on the boundary of the box which are at an odd distance from a fixed vertex v in the box, then the probability that v gets color 0 is exponentially small in d. The proof proceeds through an analysis of a certain type of cutset separating v from the boundary of the box, and builds on techniques developed by Galvin and Kahn in their proof of phase transition in the hard-core model on Z^d. Building further on these techniques, we study local Markov chains for sampling proper 3-colorings of the discrete torus Z^d_n. We show that there is a constant \rho \approx 0.22 such that for all even n \geq 4 and d sufficiently large, if M is a Markov chain on the set of proper 3-colorings of Z^d_n that updates the color of at most \rho n^d vertices at each step and whose stationary distribution is uniform, then the mixing time of M (the time taken for M to reach a distribution that is close to uniform, starting from an arbitrary coloring) is essentially exponential in n^{d-1}