Measurement of Trilinear Gauge Couplings in e+e−e^+ e^- Collisions at 161 GeV and 172 GeV

Trilinear gauge boson couplings are measured using data taken by DELPHI at 161~GeV and 172~GeV. Values for $WWV$ couplings ($V=Z, \gamma$) are determined from a study of the reactions \eeWW\ and \eeWev, using differential distributions from the $WW$ final state in which one $W$ decays hadronically and the other leptonically, and total cross-section data from other channels. Limits are also derived on neutral $ZV\gamma$ couplings from an analysis of the reaction \eegi

Neutrophils Reduce the Parasite Burden in Leishmania (Leishmania) amazonensis-Infected Macrophages

Background: Studies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis. Previous results from our laboratory showed a large infiltrate of neutrophils in the site of infection in a mouse strain resistant to L. (L.) amazonensis (C3H/HePas). in contrast, the susceptible strain (BALB/c) displayed a predominance of macrophages harboring a high number of amastigotes and very few neutrophils. These findings led us to investigate the interaction of inflammatory neutrophils with L. (L.) amazonensis-infected macrophages in vitro.Methodology/Principal Findings: Mouse peritoneal macrophages infected with L. (L.) amazonensis were co-cultured with inflammatory neutrophils, and after four days, the infection was quantified microscopically. Data are representative of three experiments with similar results. the main findings were 1) intracellular parasites were efficiently destroyed in the co-cultures; 2) the leishmanicidal effect was similar when cells were obtained from mouse strains resistant (C3H/HePas) or susceptible (BALB/c) to L. (L.) amazonensis; 3) parasite destruction did not require contact between infected macrophages and neutrophils; 4) tumor necrosis factor alpha (TNF-alpha), neutrophil elastase and platelet activating factor (PAF) were involved with the leishmanicidal activity, and 5) destruction of the parasites did not depend on generation of oxygen or nitrogen radicals, indicating that parasite clearance did not involve the classical pathway of macrophage activation by TNF-alpha, as reported for other Leishmania species.Conclusions/Significance: the present results provide evidence that neutrophils in concert with macrophages play a previously unrecognized leishmanicidal effect on L. (L.) amazonensis. We believe these findings may help to understand the mechanisms involved in innate immunity in cutaneous infection by this Leishmania species.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilWeb of Scienc

Water security threats and solutions in the Grande River basin – One of the Brazilian agricultural frontiers

This paper evaluates the effectiveness of sustainable agricultural management solutions at a farm level to mitigate water security threats in one of Brazil's agricultural frontiers – the Grande River basin. The paper addresses future challenges to water security in the river basin and explores how effective solutions are at a farm level to mitigate current and future water security threats at a basin scale. Based on the assessment of multiple drivers, higher future water security threats in the region are predicted in 2040 due to climate change, land use modification and corresponding changes in water use. The paper finds that the Formosa do Rio Preto region, which is not currently water-insecure, may turn into a water security hotspot area by 2040. The effective response index for water security (ERI-WS), based on the qualitative assessment of the impact at the farm scale, is used to evaluate the effectiveness of current sustainable management practices in addressing water security challenges. The water security dimensions approach of the ERI-WS shows that >50 % of the sites have technologies that can have positive impacts on the “Drinking water and human well-being”, “Economic activities and development”, “Ecosystem” and the “Resilience” dimensions. The paper finds that 66 % of the farms have efficient soil, land, and water management solutions (ERI-WS > 0.5) to address current and future water security issues. These solutions range from sustainable grazing land management to integrated plant nutrition management to enhanced soil productivity. However, 15 % of the farms located in vulnerable areas of the municipalities of São Desidério, Barreiras and Catolândia have lower effectiveness. Results also indicate that 36 % of the sites, distributed in 8 municipalities, employ nature-based solutions to mitigate water security threats, mainly those related to water quality conditions in downstream areas, indicating the relevance of these practices in the region.Full Tex

Vital network for Brazil: national network of information, discussion and cooperation concerning venomous animals

Regional Center of Ophiology and Venomous Animals (NOAP) Federal University of Bahia (UFBA), Salvador, Bahia StateVital Brazil Institute (IVB), Niterói, Rio de Janeiro StateThe Center for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University Universidade Estadual Paulista (UNESP)), Botucatu, São Paulo StateHouse of Vital Brazil Association (CVB), Campanha, Minas Gerais StateEzequiel Dias Foundation (FUNED), Belo Horizonte, Minas Gerais StateButantan Institute (IB), São Paulo, São Paulo StateCenter for the Production and Research on Immunobiologicals (CPPI), Piraquara, Paraná StateThe Brazilian Society of Toxinology (SBTx), São Paulo, São Paulo StateInstitute for Communication and Scientifc Technological Information on Health (ICICT) Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Rio de Janeiro StateUNESP Univ Estadual Paulista, Ctr Study Venoms & Venomous Anim CEVAP, São Paulo State Univ, Botucatu, SP, Brazi